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The Updated Registry of Fast Myocardial Perfusion Imaging with Next-Generation SPECT (REFINE SPECT 2.0)

Robert J H Miller, Mark Lemley, Aakash Shanbhag, Giselle Ramirez, Joanna X Liang, Valerie Builoff, Paul Kavanagh, Tali Sharir, M Timothy Hauser, Terrence D Ruddy, Mathews B Fish, Timothy M Bateman, Wanda Acampa, Andrew J Einstein, Sharmila Dorbala, Marcelo F Di Carli, Attila Feher, Edward J Miller, Albert J Sinusas, Julian Halcox Orcid Logo, Monica Casanova da Silva Martins, Philipp A Kaufmann, Damini Dey, Daniel S Berman, Piotr J Slomka

Journal of Nuclear Medicine

Swansea University Authors: Julian Halcox Orcid Logo, Monica Casanova da Silva Martins

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DOI (Published version): 10.2967/jnumed.124.268292

Abstract

The Registry of Fast Myocardial Perfusion Imaging with Next-Generation SPECT (REFINE SPECT) has been expanded to include more patients and CT attenuation correction imaging. We present the design and initial results from the updated registry. The updated REFINE SPECT is a multicenter, international...

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Published in: Journal of Nuclear Medicine
ISSN: 0161-5505 2159-662X
Published: Society of Nuclear Medicine and Molecular Imaging 2024
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URI: https://cronfa.swan.ac.uk/Record/cronfa68025
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We present the design and initial results from the updated registry. The updated REFINE SPECT is a multicenter, international registry with clinical data and image files. SPECT images were processed by quantitative software and CT images by deep learning software detecting coronary artery calcium (CAC). Patients were followed for major adverse cardiovascular events (MACEs) (death, myocardial infarction, unstable angina, late revascularization). The registry included scans from 45,252 patients from 13 centers (55.9% male, 64.7 ± 11.8 y). Correlating invasive coronary angiography was available for 3,786 (8.4%) patients. CT attenuation correction imaging was available for 13,405 patients. MACEs occurred in 6,514 (14.4%) patients during a median follow-up of 3.6 y (interquartile range, 2.5-4.8 y). Patients with a stress total perfusion deficit of 5% to less than 10% (unadjusted hazard ratio [HR], 2.42; 95% CI, 2.23-2.62) and a stress total perfusion deficit of at least 10% (unadjusted HR, 3.85; 95% CI, 3.56-4.16) were more likely to experience MACEs. Patients with a deep learning CAC score of 101-400 (unadjusted HR, 3.09; 95% CI, 2.57-3.72) and a CAC of more than 400 (unadjusted HR, 5.17; 95% CI, 4.41-6.05) were at increased risk of MACEs. The REFINE SPECT registry contains a comprehensive set of imaging and clinical variables. It will aid in understanding the value of SPECT myocardial perfusion imaging, leverage hybrid imaging, and facilitate validation of new artificial intelligence tools for improving prediction of adverse outcomes incorporating multimodality imaging. 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spelling v2 68025 2024-10-18 The Updated Registry of Fast Myocardial Perfusion Imaging with Next-Generation SPECT (REFINE SPECT 2.0) 3676f695eeda169d0f8c618adf27c04b 0000-0001-6926-2947 Julian Halcox Julian Halcox true false 53b42665a15b52c5b961969b11f522c0 Monica Casanova da Silva Martins Monica Casanova da Silva Martins true false 2024-10-18 MEDS The Registry of Fast Myocardial Perfusion Imaging with Next-Generation SPECT (REFINE SPECT) has been expanded to include more patients and CT attenuation correction imaging. We present the design and initial results from the updated registry. The updated REFINE SPECT is a multicenter, international registry with clinical data and image files. SPECT images were processed by quantitative software and CT images by deep learning software detecting coronary artery calcium (CAC). Patients were followed for major adverse cardiovascular events (MACEs) (death, myocardial infarction, unstable angina, late revascularization). The registry included scans from 45,252 patients from 13 centers (55.9% male, 64.7 ± 11.8 y). Correlating invasive coronary angiography was available for 3,786 (8.4%) patients. CT attenuation correction imaging was available for 13,405 patients. MACEs occurred in 6,514 (14.4%) patients during a median follow-up of 3.6 y (interquartile range, 2.5-4.8 y). Patients with a stress total perfusion deficit of 5% to less than 10% (unadjusted hazard ratio [HR], 2.42; 95% CI, 2.23-2.62) and a stress total perfusion deficit of at least 10% (unadjusted HR, 3.85; 95% CI, 3.56-4.16) were more likely to experience MACEs. Patients with a deep learning CAC score of 101-400 (unadjusted HR, 3.09; 95% CI, 2.57-3.72) and a CAC of more than 400 (unadjusted HR, 5.17; 95% CI, 4.41-6.05) were at increased risk of MACEs. The REFINE SPECT registry contains a comprehensive set of imaging and clinical variables. It will aid in understanding the value of SPECT myocardial perfusion imaging, leverage hybrid imaging, and facilitate validation of new artificial intelligence tools for improving prediction of adverse outcomes incorporating multimodality imaging. [Abstract copyright: © 2024 by the Society of Nuclear Medicine and Molecular Imaging.] Journal Article Journal of Nuclear Medicine Society of Nuclear Medicine and Molecular Imaging 0161-5505 2159-662X SPECT, solid-state detector, myocardial perfusion imaging, coronary artery disease, artificial intelligence, quantitative analysis 3 10 2024 2024-10-03 10.2967/jnumed.124.268292 Research Article, Clinical Investigation COLLEGE NANME Medical School COLLEGE CODE MEDS Swansea University Not Required 2024-10-18T12:40:38.7816961 2024-10-18T11:50:06.0848680 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Health Data Science Robert J H Miller 1 Mark Lemley 2 Aakash Shanbhag 3 Giselle Ramirez 4 Joanna X Liang 5 Valerie Builoff 6 Paul Kavanagh 7 Tali Sharir 8 M Timothy Hauser 9 Terrence D Ruddy 10 Mathews B Fish 11 Timothy M Bateman 12 Wanda Acampa 13 Andrew J Einstein 14 Sharmila Dorbala 15 Marcelo F Di Carli 16 Attila Feher 17 Edward J Miller 18 Albert J Sinusas 19 Julian Halcox 0000-0001-6926-2947 20 Monica Casanova da Silva Martins 21 Philipp A Kaufmann 22 Damini Dey 23 Daniel S Berman 24 Piotr J Slomka 25
title The Updated Registry of Fast Myocardial Perfusion Imaging with Next-Generation SPECT (REFINE SPECT 2.0)
spellingShingle The Updated Registry of Fast Myocardial Perfusion Imaging with Next-Generation SPECT (REFINE SPECT 2.0)
Julian Halcox
Monica Casanova da Silva Martins
title_short The Updated Registry of Fast Myocardial Perfusion Imaging with Next-Generation SPECT (REFINE SPECT 2.0)
title_full The Updated Registry of Fast Myocardial Perfusion Imaging with Next-Generation SPECT (REFINE SPECT 2.0)
title_fullStr The Updated Registry of Fast Myocardial Perfusion Imaging with Next-Generation SPECT (REFINE SPECT 2.0)
title_full_unstemmed The Updated Registry of Fast Myocardial Perfusion Imaging with Next-Generation SPECT (REFINE SPECT 2.0)
title_sort The Updated Registry of Fast Myocardial Perfusion Imaging with Next-Generation SPECT (REFINE SPECT 2.0)
author_id_str_mv 3676f695eeda169d0f8c618adf27c04b
53b42665a15b52c5b961969b11f522c0
author_id_fullname_str_mv 3676f695eeda169d0f8c618adf27c04b_***_Julian Halcox
53b42665a15b52c5b961969b11f522c0_***_Monica Casanova da Silva Martins
author Julian Halcox
Monica Casanova da Silva Martins
author2 Robert J H Miller
Mark Lemley
Aakash Shanbhag
Giselle Ramirez
Joanna X Liang
Valerie Builoff
Paul Kavanagh
Tali Sharir
M Timothy Hauser
Terrence D Ruddy
Mathews B Fish
Timothy M Bateman
Wanda Acampa
Andrew J Einstein
Sharmila Dorbala
Marcelo F Di Carli
Attila Feher
Edward J Miller
Albert J Sinusas
Julian Halcox
Monica Casanova da Silva Martins
Philipp A Kaufmann
Damini Dey
Daniel S Berman
Piotr J Slomka
format Journal article
container_title Journal of Nuclear Medicine
publishDate 2024
institution Swansea University
issn 0161-5505
2159-662X
doi_str_mv 10.2967/jnumed.124.268292
publisher Society of Nuclear Medicine and Molecular Imaging
college_str Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str Swansea University Medical School - Health Data Science{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Health Data Science
document_store_str 0
active_str 0
description The Registry of Fast Myocardial Perfusion Imaging with Next-Generation SPECT (REFINE SPECT) has been expanded to include more patients and CT attenuation correction imaging. We present the design and initial results from the updated registry. The updated REFINE SPECT is a multicenter, international registry with clinical data and image files. SPECT images were processed by quantitative software and CT images by deep learning software detecting coronary artery calcium (CAC). Patients were followed for major adverse cardiovascular events (MACEs) (death, myocardial infarction, unstable angina, late revascularization). The registry included scans from 45,252 patients from 13 centers (55.9% male, 64.7 ± 11.8 y). Correlating invasive coronary angiography was available for 3,786 (8.4%) patients. CT attenuation correction imaging was available for 13,405 patients. MACEs occurred in 6,514 (14.4%) patients during a median follow-up of 3.6 y (interquartile range, 2.5-4.8 y). Patients with a stress total perfusion deficit of 5% to less than 10% (unadjusted hazard ratio [HR], 2.42; 95% CI, 2.23-2.62) and a stress total perfusion deficit of at least 10% (unadjusted HR, 3.85; 95% CI, 3.56-4.16) were more likely to experience MACEs. Patients with a deep learning CAC score of 101-400 (unadjusted HR, 3.09; 95% CI, 2.57-3.72) and a CAC of more than 400 (unadjusted HR, 5.17; 95% CI, 4.41-6.05) were at increased risk of MACEs. The REFINE SPECT registry contains a comprehensive set of imaging and clinical variables. It will aid in understanding the value of SPECT myocardial perfusion imaging, leverage hybrid imaging, and facilitate validation of new artificial intelligence tools for improving prediction of adverse outcomes incorporating multimodality imaging. [Abstract copyright: © 2024 by the Society of Nuclear Medicine and Molecular Imaging.]
published_date 2024-10-03T12:40:37Z
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