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In the Murine and Bovine Maternal Mammary Gland Signal Transducer and Activator of Transcription 3 is Activated in Clusters of Epithelial Cells around the Day of Birth

Laura J. A. Hardwick, Benjamin P. Davies, Sara Pensa, Maedee Burge-Rogers, Claire Davies, André Figueiredo Baptista, Robert Knott, Ian S. McCrone, Eleonora Po Orcid Logo, Benjamin W. Strugnell Orcid Logo, Katie Waine, Paul Wood, Walid T. Khaled, Huw Summers Orcid Logo, Paul Rees Orcid Logo, John W. Wills Orcid Logo, Katherine Hughes Orcid Logo

Journal of Mammary Gland Biology and Neoplasia, Volume: 29, Issue: 1

Swansea University Authors: Huw Summers Orcid Logo, Paul Rees Orcid Logo

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DOI (Published version): 10.1007/s10911-024-09561-5

Abstract

Signal transducers and activators of transcription (STAT) proteins regulate mammary development. Here we investigate the expression of phosphorylated STAT3 (pSTAT3) in the mouse and cow around the day of birth. We present localised colocation analysis, applicable to other mammary studies requiring i...

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Published in: Journal of Mammary Gland Biology and Neoplasia
ISSN: 1083-3021 1573-7039
Published: Springer Science and Business Media LLC 2024
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URI: https://cronfa.swan.ac.uk/Record/cronfa68200
Abstract: Signal transducers and activators of transcription (STAT) proteins regulate mammary development. Here we investigate the expression of phosphorylated STAT3 (pSTAT3) in the mouse and cow around the day of birth. We present localised colocation analysis, applicable to other mammary studies requiring identification of spatially congregated events. We demonstrate that pSTAT3-positive events are multifocally clustered in a non-random and statistically significant fashion. Arginase-1 expressing cells, consistent with macrophages, exhibit distinct clustering within the periparturient mammary gland. These findings represent a new facet of mammary STAT3 biology, and point to the presence of mammary sub-microenvironments.
Keywords: Macrophage; Mammary; Parturition; STAT3; Udder; Spatial statistics
College: Faculty of Science and Engineering
Funders: LJAH was funded by a Peterhouse Research Fellowship. BPD is funded by an Anatomical Society PhD Studentship awarded to KH. This research was funded by a grant awarded to KH by the British Veterinary Association Animal Welfare Foundation Norman Hayward Fund (NHF_2016_03_KH).
Issue: 1

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