No Cover Image

Journal article 87 views 2 downloads

In the Murine and Bovine Maternal Mammary Gland Signal Transducer and Activator of Transcription 3 is Activated in Clusters of Epithelial Cells around the Day of Birth

Laura J. A. Hardwick, Benjamin P. Davies, Sara Pensa, Maedee Burge-Rogers, Claire Davies, André Figueiredo Baptista, Robert Knott, Ian S. McCrone, Eleonora Po Orcid Logo, Benjamin W. Strugnell Orcid Logo, Katie Waine, Paul Wood, Walid T. Khaled, Huw Summers Orcid Logo, Paul Rees Orcid Logo, John W. Wills Orcid Logo, Katherine Hughes Orcid Logo

Journal of Mammary Gland Biology and Neoplasia, Volume: 29, Issue: 1

Swansea University Authors: Huw Summers Orcid Logo, Paul Rees Orcid Logo

  • 68200.VoR.pdf

    PDF | Version of Record

    © The Author(s) 2024. This article is licensed under a Creative Commons Attribution 4.0 International License.

    Download (2.38MB)

Check full text

DOI (Published version): 10.1007/s10911-024-09561-5

Abstract

Signal transducers and activators of transcription (STAT) proteins regulate mammary development. Here we investigate the expression of phosphorylated STAT3 (pSTAT3) in the mouse and cow around the day of birth. We present localised colocation analysis, applicable to other mammary studies requiring i...

Full description

Published in: Journal of Mammary Gland Biology and Neoplasia
ISSN: 1083-3021 1573-7039
Published: Springer Science and Business Media LLC 2024
Online Access: Check full text

URI: https://cronfa.swan.ac.uk/Record/cronfa68200
first_indexed 2024-11-25T14:21:38Z
last_indexed 2025-01-16T20:49:09Z
id cronfa68200
recordtype SURis
fullrecord <?xml version="1.0"?><rfc1807><datestamp>2025-01-16T12:13:23.6561776</datestamp><bib-version>v2</bib-version><id>68200</id><entry>2024-11-06</entry><title>In the Murine and Bovine Maternal Mammary Gland Signal Transducer and Activator of Transcription 3 is Activated in Clusters of Epithelial Cells around the Day of Birth</title><swanseaauthors><author><sid>a61c15e220837ebfa52648c143769427</sid><ORCID>0000-0002-0898-5612</ORCID><firstname>Huw</firstname><surname>Summers</surname><name>Huw Summers</name><active>true</active><ethesisStudent>false</ethesisStudent></author><author><sid>537a2fe031a796a3bde99679ee8c24f5</sid><ORCID>0000-0002-7715-6914</ORCID><firstname>Paul</firstname><surname>Rees</surname><name>Paul Rees</name><active>true</active><ethesisStudent>false</ethesisStudent></author></swanseaauthors><date>2024-11-06</date><deptcode>EAAS</deptcode><abstract>Signal transducers and activators of transcription (STAT) proteins regulate mammary development. Here we investigate the expression of phosphorylated STAT3 (pSTAT3) in the mouse and cow around the day of birth. We present localised colocation analysis, applicable to other mammary studies requiring identification of spatially congregated events. We demonstrate that pSTAT3-positive events are multifocally clustered in a non-random and statistically significant fashion. Arginase-1 expressing cells, consistent with macrophages, exhibit distinct clustering within the periparturient mammary gland. These findings represent a new facet of mammary STAT3 biology, and point to the presence of mammary sub-microenvironments.</abstract><type>Journal Article</type><journal>Journal of Mammary Gland Biology and Neoplasia</journal><volume>29</volume><journalNumber>1</journalNumber><paginationStart/><paginationEnd/><publisher>Springer Science and Business Media LLC</publisher><placeOfPublication/><isbnPrint/><isbnElectronic/><issnPrint>1083-3021</issnPrint><issnElectronic>1573-7039</issnElectronic><keywords>Macrophage; Mammary; Parturition; STAT3; Udder; Spatial statistics</keywords><publishedDay>9</publishedDay><publishedMonth>5</publishedMonth><publishedYear>2024</publishedYear><publishedDate>2024-05-09</publishedDate><doi>10.1007/s10911-024-09561-5</doi><url/><notes/><college>COLLEGE NANME</college><department>Engineering and Applied Sciences School</department><CollegeCode>COLLEGE CODE</CollegeCode><DepartmentCode>EAAS</DepartmentCode><institution>Swansea University</institution><apcterm>Another institution paid the OA fee</apcterm><funders>LJAH was funded by a Peterhouse Research Fellowship. BPD is funded by an Anatomical Society PhD Studentship awarded to KH. This research was funded by a grant awarded to KH by the British Veterinary Association Animal Welfare Foundation Norman Hayward Fund (NHF_2016_03_KH).</funders><projectreference/><lastEdited>2025-01-16T12:13:23.6561776</lastEdited><Created>2024-11-06T19:31:02.6312324</Created><path><level id="1">Faculty of Science and Engineering</level><level id="2">School of Engineering and Applied Sciences - Biomedical Engineering</level></path><authors><author><firstname>Laura J. A.</firstname><surname>Hardwick</surname><order>1</order></author><author><firstname>Benjamin P.</firstname><surname>Davies</surname><order>2</order></author><author><firstname>Sara</firstname><surname>Pensa</surname><order>3</order></author><author><firstname>Maedee</firstname><surname>Burge-Rogers</surname><order>4</order></author><author><firstname>Claire</firstname><surname>Davies</surname><order>5</order></author><author><firstname>Andr&#xE9; Figueiredo</firstname><surname>Baptista</surname><order>6</order></author><author><firstname>Robert</firstname><surname>Knott</surname><order>7</order></author><author><firstname>Ian S.</firstname><surname>McCrone</surname><order>8</order></author><author><firstname>Eleonora</firstname><surname>Po</surname><orcid>0000-0002-9777-6707</orcid><order>9</order></author><author><firstname>Benjamin W.</firstname><surname>Strugnell</surname><orcid>0000-0001-9808-8626</orcid><order>10</order></author><author><firstname>Katie</firstname><surname>Waine</surname><order>11</order></author><author><firstname>Paul</firstname><surname>Wood</surname><order>12</order></author><author><firstname>Walid T.</firstname><surname>Khaled</surname><order>13</order></author><author><firstname>Huw</firstname><surname>Summers</surname><orcid>0000-0002-0898-5612</orcid><order>14</order></author><author><firstname>Paul</firstname><surname>Rees</surname><orcid>0000-0002-7715-6914</orcid><order>15</order></author><author><firstname>John W.</firstname><surname>Wills</surname><orcid>0000-0002-4347-5394</orcid><order>16</order></author><author><firstname>Katherine</firstname><surname>Hughes</surname><orcid>0000-0002-3331-1249</orcid><order>17</order></author></authors><documents><document><filename>68200__33354__1fa6b2e64d9f4368a7350f9b91d9c68e.pdf</filename><originalFilename>68200.VoR.pdf</originalFilename><uploaded>2025-01-16T12:11:25.4102206</uploaded><type>Output</type><contentLength>2491404</contentLength><contentType>application/pdf</contentType><version>Version of Record</version><cronfaStatus>true</cronfaStatus><documentNotes>&#xA9; The Author(s) 2024. This article is licensed under a Creative Commons Attribution 4.0 International License.</documentNotes><copyrightCorrect>true</copyrightCorrect><language>eng</language><licence>http://creativecommons.org/licenses/by/4.0/</licence></document></documents><OutputDurs/></rfc1807>
spelling 2025-01-16T12:13:23.6561776 v2 68200 2024-11-06 In the Murine and Bovine Maternal Mammary Gland Signal Transducer and Activator of Transcription 3 is Activated in Clusters of Epithelial Cells around the Day of Birth a61c15e220837ebfa52648c143769427 0000-0002-0898-5612 Huw Summers Huw Summers true false 537a2fe031a796a3bde99679ee8c24f5 0000-0002-7715-6914 Paul Rees Paul Rees true false 2024-11-06 EAAS Signal transducers and activators of transcription (STAT) proteins regulate mammary development. Here we investigate the expression of phosphorylated STAT3 (pSTAT3) in the mouse and cow around the day of birth. We present localised colocation analysis, applicable to other mammary studies requiring identification of spatially congregated events. We demonstrate that pSTAT3-positive events are multifocally clustered in a non-random and statistically significant fashion. Arginase-1 expressing cells, consistent with macrophages, exhibit distinct clustering within the periparturient mammary gland. These findings represent a new facet of mammary STAT3 biology, and point to the presence of mammary sub-microenvironments. Journal Article Journal of Mammary Gland Biology and Neoplasia 29 1 Springer Science and Business Media LLC 1083-3021 1573-7039 Macrophage; Mammary; Parturition; STAT3; Udder; Spatial statistics 9 5 2024 2024-05-09 10.1007/s10911-024-09561-5 COLLEGE NANME Engineering and Applied Sciences School COLLEGE CODE EAAS Swansea University Another institution paid the OA fee LJAH was funded by a Peterhouse Research Fellowship. BPD is funded by an Anatomical Society PhD Studentship awarded to KH. This research was funded by a grant awarded to KH by the British Veterinary Association Animal Welfare Foundation Norman Hayward Fund (NHF_2016_03_KH). 2025-01-16T12:13:23.6561776 2024-11-06T19:31:02.6312324 Faculty of Science and Engineering School of Engineering and Applied Sciences - Biomedical Engineering Laura J. A. Hardwick 1 Benjamin P. Davies 2 Sara Pensa 3 Maedee Burge-Rogers 4 Claire Davies 5 André Figueiredo Baptista 6 Robert Knott 7 Ian S. McCrone 8 Eleonora Po 0000-0002-9777-6707 9 Benjamin W. Strugnell 0000-0001-9808-8626 10 Katie Waine 11 Paul Wood 12 Walid T. Khaled 13 Huw Summers 0000-0002-0898-5612 14 Paul Rees 0000-0002-7715-6914 15 John W. Wills 0000-0002-4347-5394 16 Katherine Hughes 0000-0002-3331-1249 17 68200__33354__1fa6b2e64d9f4368a7350f9b91d9c68e.pdf 68200.VoR.pdf 2025-01-16T12:11:25.4102206 Output 2491404 application/pdf Version of Record true © The Author(s) 2024. This article is licensed under a Creative Commons Attribution 4.0 International License. true eng http://creativecommons.org/licenses/by/4.0/
title In the Murine and Bovine Maternal Mammary Gland Signal Transducer and Activator of Transcription 3 is Activated in Clusters of Epithelial Cells around the Day of Birth
spellingShingle In the Murine and Bovine Maternal Mammary Gland Signal Transducer and Activator of Transcription 3 is Activated in Clusters of Epithelial Cells around the Day of Birth
Huw Summers
Paul Rees
title_short In the Murine and Bovine Maternal Mammary Gland Signal Transducer and Activator of Transcription 3 is Activated in Clusters of Epithelial Cells around the Day of Birth
title_full In the Murine and Bovine Maternal Mammary Gland Signal Transducer and Activator of Transcription 3 is Activated in Clusters of Epithelial Cells around the Day of Birth
title_fullStr In the Murine and Bovine Maternal Mammary Gland Signal Transducer and Activator of Transcription 3 is Activated in Clusters of Epithelial Cells around the Day of Birth
title_full_unstemmed In the Murine and Bovine Maternal Mammary Gland Signal Transducer and Activator of Transcription 3 is Activated in Clusters of Epithelial Cells around the Day of Birth
title_sort In the Murine and Bovine Maternal Mammary Gland Signal Transducer and Activator of Transcription 3 is Activated in Clusters of Epithelial Cells around the Day of Birth
author_id_str_mv a61c15e220837ebfa52648c143769427
537a2fe031a796a3bde99679ee8c24f5
author_id_fullname_str_mv a61c15e220837ebfa52648c143769427_***_Huw Summers
537a2fe031a796a3bde99679ee8c24f5_***_Paul Rees
author Huw Summers
Paul Rees
author2 Laura J. A. Hardwick
Benjamin P. Davies
Sara Pensa
Maedee Burge-Rogers
Claire Davies
André Figueiredo Baptista
Robert Knott
Ian S. McCrone
Eleonora Po
Benjamin W. Strugnell
Katie Waine
Paul Wood
Walid T. Khaled
Huw Summers
Paul Rees
John W. Wills
Katherine Hughes
format Journal article
container_title Journal of Mammary Gland Biology and Neoplasia
container_volume 29
container_issue 1
publishDate 2024
institution Swansea University
issn 1083-3021
1573-7039
doi_str_mv 10.1007/s10911-024-09561-5
publisher Springer Science and Business Media LLC
college_str Faculty of Science and Engineering
hierarchytype
hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Engineering and Applied Sciences - Biomedical Engineering{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Engineering and Applied Sciences - Biomedical Engineering
document_store_str 1
active_str 0
description Signal transducers and activators of transcription (STAT) proteins regulate mammary development. Here we investigate the expression of phosphorylated STAT3 (pSTAT3) in the mouse and cow around the day of birth. We present localised colocation analysis, applicable to other mammary studies requiring identification of spatially congregated events. We demonstrate that pSTAT3-positive events are multifocally clustered in a non-random and statistically significant fashion. Arginase-1 expressing cells, consistent with macrophages, exhibit distinct clustering within the periparturient mammary gland. These findings represent a new facet of mammary STAT3 biology, and point to the presence of mammary sub-microenvironments.
published_date 2024-05-09T14:41:25Z
_version_ 1821960448757465088
score 11.048149

Similar Items