Journal article 170 views 7 downloads
Trajectory of health-related quality of life during and after hospitalisation due to worsening of heart failure
,
Ka Keat Lim ,
Kok Han Chee ,
Sazzli Kasim ,
Juman Al-Dujaili ,
Kenneth Kwing-Chin Lee ,
Siew Li Teoh
Quality of Life Research, Volume: 34, Issue: 2, Pages: 471 - 484
Swansea University Author:
Juman Al-Dujaili
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© The Author(s) 2024. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License (CC-BY 4.0).
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DOI (Published version): 10.1007/s11136-024-03818-6
Abstract
This study aimed to examine the trajectory in health-related quality of life (HRQoL) during and after hospitalisation for worsening of heart failure (HF) in Malaysia. 200 patients with heart failure and reduced ejection fraction (HFrEF) admitted into two hospitals in Malaysia due to worsening of HF...
| Published in: | Quality of Life Research |
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| ISSN: | 0962-9343 1573-2649 |
| Published: |
Springer Nature
2025
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| Online Access: |
Check full text
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| URI: | https://cronfa.swan.ac.uk/Record/cronfa68506 |
| Abstract: |
This study aimed to examine the trajectory in health-related quality of life (HRQoL) during and after hospitalisation for worsening of heart failure (HF) in Malaysia. 200 patients with heart failure and reduced ejection fraction (HFrEF) admitted into two hospitals in Malaysia due to worsening of HF were surveyed using the EQ-5D-5 L questionnaire. The primary outcomes were utility values at admission, discharge and 1-month post-discharge (1MPD). Secondary outcomes included the visual analogue scores (VAS) and the proportion of patients reporting each EQ-5D-5 L dimension levels. Missing data were imputed using multiple imputation, and generalised linear mixed models were fitted. At admission, the unadjusted mean utility values and VAS scores for HFrEF patients in Malaysia were as low as 0.150 ± 0.393 and 38.2 ± 20.8, respectively. After a median hospital stay of 4 days, there was a significant improvement in utility values and VAS scores by 0.510 (95% CI: 0.455-0.564) and 28.8 (95% CI: 25.5-32.1), respectively. The utility value and VAS score at 1-month post-discharge were not significantly different from discharge. The proportion of HFrEF patients reporting problems and severe problems in mobility, self-care, usual activities, and anxiety/depression, pain/discomfort reduced at varying degree from admission to discharge and 1MPD. HF is a progressive condition with substantial variation in HRQoL during the disease trajectory. During hospitalisation due to worsening of HF, HFrEF population has unfavourable HRQoL. Rapid and significant HRQoL improvement was observed at discharge, which sustained over one month. The study findings can inform future cost-effectiveness analyses and policies. |
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| Keywords: |
Heart failure; Health-related quality of life; EQ-5D; Utility; Visual analogue score; Hospitalisation |
| College: |
Faculty of Medicine, Health and Life Sciences |
| Funders: |
No funding is available for this study. Open Access funding enabled and organized by CAUL and its Member Institutions. |
| Issue: |
2 |
| Start Page: |
471 |
| End Page: |
484 |