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Trajectory of health-related quality of life during and after hospitalisation due to worsening of heart failure

Wai Chee Kuan Orcid Logo, Ka Keat Lim Orcid Logo, Kok Han Chee Orcid Logo, Sazzli Kasim Orcid Logo, Juman Al-Dujaili Orcid Logo, Kenneth Kwing-Chin Lee Orcid Logo, Siew Li Teoh Orcid Logo

Quality of Life Research, Volume: 34, Issue: 2, Pages: 471 - 484

Swansea University Author: Juman Al-Dujaili Orcid Logo

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DOI (Published version): 10.1007/s11136-024-03818-6

Abstract

This study aimed to examine the trajectory in health-related quality of life (HRQoL) during and after hospitalisation for worsening of heart failure (HF) in Malaysia. 200 patients with heart failure and reduced ejection fraction (HFrEF) admitted into two hospitals in Malaysia due to worsening of HF...

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Published in: Quality of Life Research
ISSN: 0962-9343 1573-2649
Published: Springer Nature 2025
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URI: https://cronfa.swan.ac.uk/Record/cronfa68506
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The primary outcomes were utility values at admission, discharge and 1-month post-discharge (1MPD). Secondary outcomes included the visual analogue scores (VAS) and the proportion of patients reporting each EQ-5D-5&#xA0;L dimension levels. Missing data were imputed using multiple imputation, and generalised linear mixed models were fitted. At admission, the unadjusted mean utility values and VAS scores for HFrEF patients in Malaysia were as low as 0.150&#x2009;&#xB1;&#x2009;0.393 and 38.2&#x2009;&#xB1;&#x2009;20.8, respectively. After a median hospital stay of 4 days, there was a significant improvement in utility values and VAS scores by 0.510 (95% CI: 0.455-0.564) and 28.8 (95% CI: 25.5-32.1), respectively. The utility value and VAS score at 1-month post-discharge were not significantly different from discharge. The proportion of HFrEF patients reporting problems and severe problems in mobility, self-care, usual activities, and anxiety/depression, pain/discomfort reduced at varying degree from admission to discharge and 1MPD. HF is a progressive condition with substantial variation in HRQoL during the disease trajectory. During hospitalisation due to worsening of HF, HFrEF population has unfavourable HRQoL. Rapid and significant HRQoL improvement was observed at discharge, which sustained over one month. 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spelling 2025-03-18T15:43:27.9016415 v2 68506 2024-12-09 Trajectory of health-related quality of life during and after hospitalisation due to worsening of heart failure 47d192c8bb46dd4c0cc72bbfea4210ec 0000-0002-7515-5344 Juman Al-Dujaili Juman Al-Dujaili true false 2024-12-09 MEDS This study aimed to examine the trajectory in health-related quality of life (HRQoL) during and after hospitalisation for worsening of heart failure (HF) in Malaysia. 200 patients with heart failure and reduced ejection fraction (HFrEF) admitted into two hospitals in Malaysia due to worsening of HF were surveyed using the EQ-5D-5 L questionnaire. The primary outcomes were utility values at admission, discharge and 1-month post-discharge (1MPD). Secondary outcomes included the visual analogue scores (VAS) and the proportion of patients reporting each EQ-5D-5 L dimension levels. Missing data were imputed using multiple imputation, and generalised linear mixed models were fitted. At admission, the unadjusted mean utility values and VAS scores for HFrEF patients in Malaysia were as low as 0.150 ± 0.393 and 38.2 ± 20.8, respectively. After a median hospital stay of 4 days, there was a significant improvement in utility values and VAS scores by 0.510 (95% CI: 0.455-0.564) and 28.8 (95% CI: 25.5-32.1), respectively. The utility value and VAS score at 1-month post-discharge were not significantly different from discharge. The proportion of HFrEF patients reporting problems and severe problems in mobility, self-care, usual activities, and anxiety/depression, pain/discomfort reduced at varying degree from admission to discharge and 1MPD. HF is a progressive condition with substantial variation in HRQoL during the disease trajectory. During hospitalisation due to worsening of HF, HFrEF population has unfavourable HRQoL. Rapid and significant HRQoL improvement was observed at discharge, which sustained over one month. The study findings can inform future cost-effectiveness analyses and policies. Journal Article Quality of Life Research 34 2 471 484 Springer Nature 0962-9343 1573-2649 Heart failure; Health-related quality of life; EQ-5D; Utility; Visual analogue score; Hospitalisation 28 2 2025 2025-02-28 10.1007/s11136-024-03818-6 COLLEGE NANME Medical School COLLEGE CODE MEDS Swansea University Another institution paid the OA fee No funding is available for this study. Open Access funding enabled and organized by CAUL and its Member Institutions. 2025-03-18T15:43:27.9016415 2024-12-09T15:14:46.9510391 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Pharmacy Wai Chee Kuan 0000-0002-6243-1194 1 Ka Keat Lim 0000-0002-2340-4097 2 Kok Han Chee 0000-0002-4485-0504 3 Sazzli Kasim 0000-0003-4585-7713 4 Juman Al-Dujaili 0000-0002-7515-5344 5 Kenneth Kwing-Chin Lee 0000-0002-2583-0030 6 Siew Li Teoh 0000-0003-4163-7895 7 68506__33091__764e7c2b62354ba091452fb1e025603b.pdf 68506.VOR.pdf 2024-12-09T15:21:07.4584307 Output 1391840 application/pdf Version of Record true © The Author(s) 2024. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License (CC-BY 4.0). true eng http://creativecommons.org/licenses/by/4.0/
title Trajectory of health-related quality of life during and after hospitalisation due to worsening of heart failure
spellingShingle Trajectory of health-related quality of life during and after hospitalisation due to worsening of heart failure
Juman Al-Dujaili
title_short Trajectory of health-related quality of life during and after hospitalisation due to worsening of heart failure
title_full Trajectory of health-related quality of life during and after hospitalisation due to worsening of heart failure
title_fullStr Trajectory of health-related quality of life during and after hospitalisation due to worsening of heart failure
title_full_unstemmed Trajectory of health-related quality of life during and after hospitalisation due to worsening of heart failure
title_sort Trajectory of health-related quality of life during and after hospitalisation due to worsening of heart failure
author_id_str_mv 47d192c8bb46dd4c0cc72bbfea4210ec
author_id_fullname_str_mv 47d192c8bb46dd4c0cc72bbfea4210ec_***_Juman Al-Dujaili
author Juman Al-Dujaili
author2 Wai Chee Kuan
Ka Keat Lim
Kok Han Chee
Sazzli Kasim
Juman Al-Dujaili
Kenneth Kwing-Chin Lee
Siew Li Teoh
format Journal article
container_title Quality of Life Research
container_volume 34
container_issue 2
container_start_page 471
publishDate 2025
institution Swansea University
issn 0962-9343
1573-2649
doi_str_mv 10.1007/s11136-024-03818-6
publisher Springer Nature
college_str Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str Swansea University Medical School - Pharmacy{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Pharmacy
document_store_str 1
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description This study aimed to examine the trajectory in health-related quality of life (HRQoL) during and after hospitalisation for worsening of heart failure (HF) in Malaysia. 200 patients with heart failure and reduced ejection fraction (HFrEF) admitted into two hospitals in Malaysia due to worsening of HF were surveyed using the EQ-5D-5 L questionnaire. The primary outcomes were utility values at admission, discharge and 1-month post-discharge (1MPD). Secondary outcomes included the visual analogue scores (VAS) and the proportion of patients reporting each EQ-5D-5 L dimension levels. Missing data were imputed using multiple imputation, and generalised linear mixed models were fitted. At admission, the unadjusted mean utility values and VAS scores for HFrEF patients in Malaysia were as low as 0.150 ± 0.393 and 38.2 ± 20.8, respectively. After a median hospital stay of 4 days, there was a significant improvement in utility values and VAS scores by 0.510 (95% CI: 0.455-0.564) and 28.8 (95% CI: 25.5-32.1), respectively. The utility value and VAS score at 1-month post-discharge were not significantly different from discharge. The proportion of HFrEF patients reporting problems and severe problems in mobility, self-care, usual activities, and anxiety/depression, pain/discomfort reduced at varying degree from admission to discharge and 1MPD. HF is a progressive condition with substantial variation in HRQoL during the disease trajectory. During hospitalisation due to worsening of HF, HFrEF population has unfavourable HRQoL. Rapid and significant HRQoL improvement was observed at discharge, which sustained over one month. The study findings can inform future cost-effectiveness analyses and policies.
published_date 2025-02-28T08:23:15Z
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