Conference Paper/Proceeding/Abstract 24 views
Bioinspired Two Photon Polymerized Surface Textured Microstructure Antibacterial Surfaces
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Ning Tan,
Nigel Neate,
Keyvan Jodeiri,
Ricky D. Wildman,
Maxine Swee-Li Yee
Biomaterials, Biodegradables and Biomimetics - 3Bs Materials 2024 International Conference, Volume: Proceedings of the Biomaterials, Biodegradables and Biomimetics - 3Bs Materials 2024 International Conference Seville, Spain – March 06 – 08, 2024, Pages: 2 - 6
Swansea University Author:
Georgina Marsh
Full text not available from this repository: check for access using links below.
DOI (Published version): 10.26799/cp-3bsmaterials-2024
Abstract
Healthcare-associated infections (HAIs) encompass all infections linked to medical procedures or exposure to healthcare environments. However, several primary risk factors for infection development are associated with the usage of implanted devices and indwelling devices. Notably, infections related...
| Published in: | Biomaterials, Biodegradables and Biomimetics - 3Bs Materials 2024 International Conference |
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| Published: |
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| Online Access: |
https://www.setcor.org/publications |
| URI: | https://cronfa.swan.ac.uk/Record/cronfa68514 |
| Abstract: |
Healthcare-associated infections (HAIs) encompass all infections linked to medical procedures or exposure to healthcare environments. However, several primary risk factors for infection development are associated with the usage of implanted devices and indwelling devices. Notably, infections related to implants contribute to at least 25% of all HAIs in the US. To mitigate this risk, prophylactic antimicrobials are often required, further exacerbating the proliferation of antibiotic resistance. Consequently, there is a growing demand for surfaces capable of preventing bacterial attachment and colonization.Numerous studies have explored the potential of natural surfaces to exhibit antibiofouling and antibacterial properties. The self-cleaning characteristics of the lotus leaf and the microstructures present on the Japanese edible crab, are renowned for deterring bacterial cell attachment, aiding in the prevention of biofilm formation. In this study, our objective is to fabricate microstructures, on a scale comparable to these natural surfaces, using a two photon polymerization 3D printer. By culturing P. aeruginosa on these surfaces we can then investigate the influence of micropillar surface characteristics on P. aeruginosa attachment or response. Biomimetic microstructures were successfully created with differing spacings and precisely controllable surface textures. The 5 µm spacing, showed to produce greater antibacterial effect. The 5 µm spacing demonstrated an improved antibacterial effect and vertical ridges on the walls of the microstructures, showed the lowest cell adhesion to the microstructures themselves, but increased clustering around their base. |
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| Keywords: |
Two photon polymerization, biomimetic, micropillared surfaces, biofilm, antibacterial. |
| College: |
Faculty of Medicine, Health and Life Sciences |
| Funders: |
Ministry of Higher Education Malaysia FRGS/1/2020/TK0/UNIM/03/3, University of Nottingham Malaysia FOSE internal grant LA744019 |
| Start Page: |
2 |
| End Page: |
6 |