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Ischemic Preconditioning Negatively Affects Thrombogenic Clotting Profile in Cerebral Small Vessel Occlusion Stroke Patients
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Nicolai Rytter ,
Laura Cathrine Christoffersen ,
Lasse Gliemann ,
Christian Stevns Hansen ,
Matthew Lawrence,
Adrian Evans,
Christina Kruuse ,
Ylva Hellsten
Journal of Clinical Medicine Research, Volume: 17, Issue: 2, Pages: 97 - 105
Swansea University Author: Adrian Evans
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DOI (Published version): 10.14740/jocmr6086
Abstract
Background: The study evaluated the effect of an acute and a 2-week daily repetitive ischemic preconditioning (IPC) on conduit artery vascular function and thrombogenic clotting profile, in patients with a recent ischemic stroke.Methods: Fourteen patients, aged 71 ± 8 years, with a cerebral small ve...
| Published in: | Journal of Clinical Medicine Research |
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| ISSN: | 1918-3003 1918-3011 |
| Published: |
Elmer Press, Inc.
2025
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| Online Access: |
Check full text
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| URI: | https://cronfa.swan.ac.uk/Record/cronfa69257 |
| Abstract: |
Background: The study evaluated the effect of an acute and a 2-week daily repetitive ischemic preconditioning (IPC) on conduit artery vascular function and thrombogenic clotting profile, in patients with a recent ischemic stroke.Methods: Fourteen patients, aged 71 ± 8 years, with a cerebral small vessel occlusion stroke were included in a randomized, controlled, open-label cross-over study. Treatment consisted of 2 weeks of daily IPC, four 5-min rounds of upper-arm occlusion, interspersed by 5 min rest periods. Control was without treatment. Brachial artery flow-mediated dilation (FMD) was determined at baseline and after the control and treatment periods. Before and after each period, the patients underwent an acute bout of IPC. Blood samples were obtained for thrombogenic clotting profile at baseline and after the acute IPC bout, both before and after the control and treatment periods.Results: The period of daily IPC increased brachial artery diameter but did not influence FMD. Acutely, IPC was found to induce an increase in fractal dimension, indicating a denser clot microstructure, and a reduction in plasma levels of plasminogen activator inhibitor 1 (PAI-1). There was no effect of daily IPC on the basal thrombogenic clotting profile, or on the change in clotting profile induced by acute IPC.Conclusions: Collectively, the data show that acute IPC leads to a prothrombotic clotting profile, despite antiplatelet therapy. Moreover, 2 weeks of daily treatment with IPC does not influence conduit artery vascular function or thrombogenicity in stroke patients. |
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| Keywords: |
Cerebral small vessel occlusion stroke; Vascular func-tion; Preconditioning; Clotting profile |
| College: |
Faculty of Medicine, Health and Life Sciences |
| Funders: |
The study was funded by Independent Research Fund, Denmark, Medical and Health Sciences. |
| Issue: |
2 |
| Start Page: |
97 |
| End Page: |
105 |