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Ischemic Preconditioning Negatively Affects Thrombogenic Clotting Profile in Cerebral Small Vessel Occlusion Stroke Patients

Line Boel Norregaard Orcid Logo, Nicolai Rytter Orcid Logo, Laura Cathrine Christoffersen Orcid Logo, Lasse Gliemann Orcid Logo, Christian Stevns Hansen Orcid Logo, Matthew Lawrence, Adrian Evans, Christina Kruuse Orcid Logo, Ylva Hellsten Orcid Logo

Journal of Clinical Medicine Research, Volume: 17, Issue: 2, Pages: 97 - 105

Swansea University Author: Adrian Evans

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DOI (Published version): 10.14740/jocmr6086

Abstract

Background: The study evaluated the effect of an acute and a 2-week daily repetitive ischemic preconditioning (IPC) on conduit artery vascular function and thrombogenic clotting profile, in patients with a recent ischemic stroke.Methods: Fourteen patients, aged 71 ± 8 years, with a cerebral small ve...

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Published in: Journal of Clinical Medicine Research
ISSN: 1918-3003 1918-3011
Published: Elmer Press, Inc. 2025
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URI: https://cronfa.swan.ac.uk/Record/cronfa69257
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Treatment consisted of 2 weeks of daily IPC, four 5-min rounds of upper-arm occlusion, interspersed by 5 min rest periods. Control was without treatment. Brachial artery flow-mediated dilation (FMD) was determined at baseline and after the control and treatment periods. Before and after each period, the patients underwent an acute bout of IPC. Blood samples were obtained for thrombogenic clotting profile at baseline and after the acute IPC bout, both before and after the control and treatment periods.Results: The period of daily IPC increased brachial artery diameter but did not influence FMD. Acutely, IPC was found to induce an increase in fractal dimension, indicating a denser clot microstructure, and a reduction in plasma levels of plasminogen activator inhibitor 1 (PAI-1). There was no effect of daily IPC on the basal thrombogenic clotting profile, or on the change in clotting profile induced by acute IPC.Conclusions: Collectively, the data show that acute IPC leads to a prothrombotic clotting profile, despite antiplatelet therapy. 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spelling 2025-05-23T13:09:17.2798075 v2 69257 2025-04-10 Ischemic Preconditioning Negatively Affects Thrombogenic Clotting Profile in Cerebral Small Vessel Occlusion Stroke Patients 21761f6eb805546a561c9f036e85405b Adrian Evans Adrian Evans true false 2025-04-10 Background: The study evaluated the effect of an acute and a 2-week daily repetitive ischemic preconditioning (IPC) on conduit artery vascular function and thrombogenic clotting profile, in patients with a recent ischemic stroke.Methods: Fourteen patients, aged 71 ± 8 years, with a cerebral small vessel occlusion stroke were included in a randomized, controlled, open-label cross-over study. Treatment consisted of 2 weeks of daily IPC, four 5-min rounds of upper-arm occlusion, interspersed by 5 min rest periods. Control was without treatment. Brachial artery flow-mediated dilation (FMD) was determined at baseline and after the control and treatment periods. Before and after each period, the patients underwent an acute bout of IPC. Blood samples were obtained for thrombogenic clotting profile at baseline and after the acute IPC bout, both before and after the control and treatment periods.Results: The period of daily IPC increased brachial artery diameter but did not influence FMD. Acutely, IPC was found to induce an increase in fractal dimension, indicating a denser clot microstructure, and a reduction in plasma levels of plasminogen activator inhibitor 1 (PAI-1). There was no effect of daily IPC on the basal thrombogenic clotting profile, or on the change in clotting profile induced by acute IPC.Conclusions: Collectively, the data show that acute IPC leads to a prothrombotic clotting profile, despite antiplatelet therapy. Moreover, 2 weeks of daily treatment with IPC does not influence conduit artery vascular function or thrombogenicity in stroke patients. Journal Article Journal of Clinical Medicine Research 17 2 97 105 Elmer Press, Inc. 1918-3003 1918-3011 Cerebral small vessel occlusion stroke; Vascular func-tion; Preconditioning; Clotting profile 13 2 2025 2025-02-13 10.14740/jocmr6086 COLLEGE NANME COLLEGE CODE Swansea University The study was funded by Independent Research Fund, Denmark, Medical and Health Sciences. 2025-05-23T13:09:17.2798075 2025-04-10T12:36:05.6836814 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medicine Line Boel Norregaard 0000-0003-1843-2648 1 Nicolai Rytter 0000-0002-7885-5653 2 Laura Cathrine Christoffersen 0000-0002-4765-6854 3 Lasse Gliemann 0000-0002-0382-2523 4 Christian Stevns Hansen 0000-0002-5782-3476 5 Matthew Lawrence 6 Adrian Evans 7 Christina Kruuse 0000-0002-4210-0523 8 Ylva Hellsten 0000-0002-2435-9558 9 69257__34343__8a218325192740efb4bb580de2b1b795.pdf 69257.VoR.pdf 2025-05-23T13:06:28.7513565 Output 1528598 application/pdf Version of Record true © The authors. This article is distributed under the terms of the Creative Commons Attribution Non-Commercial 4.0 International License. true eng https://creativecommons.org/licenses/by-nc/4.0/
title Ischemic Preconditioning Negatively Affects Thrombogenic Clotting Profile in Cerebral Small Vessel Occlusion Stroke Patients
spellingShingle Ischemic Preconditioning Negatively Affects Thrombogenic Clotting Profile in Cerebral Small Vessel Occlusion Stroke Patients
Adrian Evans
title_short Ischemic Preconditioning Negatively Affects Thrombogenic Clotting Profile in Cerebral Small Vessel Occlusion Stroke Patients
title_full Ischemic Preconditioning Negatively Affects Thrombogenic Clotting Profile in Cerebral Small Vessel Occlusion Stroke Patients
title_fullStr Ischemic Preconditioning Negatively Affects Thrombogenic Clotting Profile in Cerebral Small Vessel Occlusion Stroke Patients
title_full_unstemmed Ischemic Preconditioning Negatively Affects Thrombogenic Clotting Profile in Cerebral Small Vessel Occlusion Stroke Patients
title_sort Ischemic Preconditioning Negatively Affects Thrombogenic Clotting Profile in Cerebral Small Vessel Occlusion Stroke Patients
author_id_str_mv 21761f6eb805546a561c9f036e85405b
author_id_fullname_str_mv 21761f6eb805546a561c9f036e85405b_***_Adrian Evans
author Adrian Evans
author2 Line Boel Norregaard
Nicolai Rytter
Laura Cathrine Christoffersen
Lasse Gliemann
Christian Stevns Hansen
Matthew Lawrence
Adrian Evans
Christina Kruuse
Ylva Hellsten
format Journal article
container_title Journal of Clinical Medicine Research
container_volume 17
container_issue 2
container_start_page 97
publishDate 2025
institution Swansea University
issn 1918-3003
1918-3011
doi_str_mv 10.14740/jocmr6086
publisher Elmer Press, Inc.
college_str Faculty of Medicine, Health and Life Sciences
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hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str Swansea University Medical School - Medicine{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Medicine
document_store_str 1
active_str 0
description Background: The study evaluated the effect of an acute and a 2-week daily repetitive ischemic preconditioning (IPC) on conduit artery vascular function and thrombogenic clotting profile, in patients with a recent ischemic stroke.Methods: Fourteen patients, aged 71 ± 8 years, with a cerebral small vessel occlusion stroke were included in a randomized, controlled, open-label cross-over study. Treatment consisted of 2 weeks of daily IPC, four 5-min rounds of upper-arm occlusion, interspersed by 5 min rest periods. Control was without treatment. Brachial artery flow-mediated dilation (FMD) was determined at baseline and after the control and treatment periods. Before and after each period, the patients underwent an acute bout of IPC. Blood samples were obtained for thrombogenic clotting profile at baseline and after the acute IPC bout, both before and after the control and treatment periods.Results: The period of daily IPC increased brachial artery diameter but did not influence FMD. Acutely, IPC was found to induce an increase in fractal dimension, indicating a denser clot microstructure, and a reduction in plasma levels of plasminogen activator inhibitor 1 (PAI-1). There was no effect of daily IPC on the basal thrombogenic clotting profile, or on the change in clotting profile induced by acute IPC.Conclusions: Collectively, the data show that acute IPC leads to a prothrombotic clotting profile, despite antiplatelet therapy. Moreover, 2 weeks of daily treatment with IPC does not influence conduit artery vascular function or thrombogenicity in stroke patients.
published_date 2025-02-13T09:55:33Z
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