Natural products from Xenorhabdus and Photorhabdus show promise as biolarvicides against Aedes albopictus

Touray, Mustapha; Ulug, Derya; Gulsen, Sebnem Hazal; Cimen, Harun; Hazir, Canan; Bode, Helge B.; Hazir, Selcuk

doi:10.1002/ps.8127

Journal article 243 views 66 downloads

Natural products from Xenorhabdus and Photorhabdus show promise as biolarvicides against Aedes albopictus

Mustapha Touray

, Derya Ulug, Sebnem Hazal Gulsen, Harun Cimen, Canan Hazir, Helge B. Bode, Selcuk Hazir

Pest Management Science, Volume: 80, Issue: 9, Pages: 4231 - 4242

Swansea University Author: Mustapha Touray

PDF | Version of Record

© 2024 The Authors. Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry. This is an open access article under the terms of the Creative Commons Attribution License.
Download (1020.69KB)

Check full text

DOI (Published version): 10.1002/ps.8127

Abstract

BACKGROUND: In the perpetual struggle to manage mosquito populations, there has been increasing demand for the development of biopesticides to supplant/complement current products. The insecticidal potential of Xenorhabdus and Photorhabdus has long been recognized and is of interest for the control...

Full description

Published in:	Pest Management Science
ISSN:	1526-498X 1526-4998
Published:	Wiley 2024
Online Access:	Check full text
URI:	https://cronfa.swan.ac.uk/Record/cronfa69461

first_indexed	2025-05-08T22:02:03Z
last_indexed	2025-06-18T04:56:28Z
id	cronfa69461
recordtype	SURis
fullrecord	<?xml version="1.0"?><rfc1807><datestamp>2025-06-17T13:39:36.1152810</datestamp><bib-version>v2</bib-version><id>69461</id><entry>2025-05-08</entry><title>Natural products from <i>Xenorhabdus</i> and <i>Photorhabdus</i> show promise as biolarvicides against <i>Aedes albopictus</i></title><swanseaauthors><author><sid>525f9e9af0d60813fdaee65dc0cb7cdf</sid><ORCID>0000-0002-9550-0782</ORCID><firstname>Mustapha</firstname><surname>Touray</surname><name>Mustapha Touray</name><active>true</active><ethesisStudent>false</ethesisStudent></author></swanseaauthors><date>2025-05-08</date><deptcode>BGPS</deptcode><abstract>BACKGROUND: In the perpetual struggle to manage mosquito populations, there has been increasing demand for the development of biopesticides to supplant/complement current products. The insecticidal potential of Xenorhabdus and Photorhabdus has long been recognized and is of interest for the control of important mosquitoes like Aedes albopictus which vectors over 20 different arboviruses of global public health concern. RESULTS: The larvicidal effects of cell-free supernatants, cell growth cultures and cell mass of an extensive list of Xenorhabdus and Photorhabdus spp. was investigated. They were quite effective against Ae. albopictus causing larval mortality ranging between 52–100%. Three Photorhabdus spp. and 13 Xenorhabdus spp. release larvicidal compounds in cell-free supernatants. Cell growth culture of all tested species exhibited larvicidal activity, except for Xenorhabdus sp. TS4. Twenty-one Xenorhabdus and Photorhabdus bacterial cells (pellet) exhibited oral toxicity (59–91%) against exposed larvae. The effect of bacterial supernatants on the mosquito eggs were also assessed. Bacterial supernatants inhibited the hatching of mosquito eggs; when unhatched eggs were transferred to clean water, they all hatched. Using the easyPACId approach, the larvicidal compounds in bacterial supernatant were identified as fabclavine from X. szentirmaii and xencoumacin from X. nematophila (causing 98 and 70% mortality, respectively, after 48 h). Xenorhabdus cabanillasii and X. hominickii fabclavines were as effective as commercial Bacillus thuringiensis subsp. israelensis and spinosad products within 5 days post-application (dpa). CONCLUSION: Fabclavine and xenocoumacin can be developed into novel biolarvicides, can be used as a model to synthesize other compounds or/and can be combined with other commercial biolarvicides.</abstract><type>Journal Article</type><journal>Pest Management Science</journal><volume>80</volume><journalNumber>9</journalNumber><paginationStart>4231</paginationStart><paginationEnd>4242</paginationEnd><publisher>Wiley</publisher><placeOfPublication/><isbnPrint/><isbnElectronic/><issnPrint>1526-498X</issnPrint><issnElectronic>1526-4998</issnElectronic><keywords>Aedes albopictus, larvicidal, Xenorhabdus, Photorhabdus, fabclavine, xenocoumacin</keywords><publishedDay>1</publishedDay><publishedMonth>9</publishedMonth><publishedYear>2024</publishedYear><publishedDate>2024-09-01</publishedDate><doi>10.1002/ps.8127</doi><url/><notes/><college>COLLEGE NANME</college><department>Biosciences Geography and Physics School</department><CollegeCode>COLLEGE CODE</CollegeCode><DepartmentCode>BGPS</DepartmentCode><institution>Swansea University</institution><apcterm>Another institution paid the OA fee</apcterm><funders>Türkiye Bilimsel ve Teknolojik Araştırma Kurumu. Grant Number: TUBITAK-116Z074; European Research Council. Grant Number: 835108; LOEWE-Centre Translational Biodiversity Genomics (TBG) of the State of Hesse; Aydin Adnan Menderes University. Grant Number: FEF-22014</funders><projectreference/><lastEdited>2025-06-17T13:39:36.1152810</lastEdited><Created>2025-05-08T22:46:26.8870969</Created><path><level id="1">Faculty of Science and Engineering</level><level id="2">School of Biosciences, Geography and Physics - Biosciences</level></path><authors><author><firstname>Mustapha</firstname><surname>Touray</surname><orcid>0000-0002-9550-0782</orcid><order>1</order></author><author><firstname>Derya</firstname><surname>Ulug</surname><order>2</order></author><author><firstname>Sebnem Hazal</firstname><surname>Gulsen</surname><order>3</order></author><author><firstname>Harun</firstname><surname>Cimen</surname><order>4</order></author><author><firstname>Canan</firstname><surname>Hazir</surname><order>5</order></author><author><firstname>Helge B.</firstname><surname>Bode</surname><order>6</order></author><author><firstname>Selcuk</firstname><surname>Hazir</surname><order>7</order></author></authors><documents><document><filename>69461__34495__81be37e5128442c99bcc706ce9539838.pdf</filename><originalFilename>69461.VOR.pdf</originalFilename><uploaded>2025-06-17T13:37:23.3219766</uploaded><type>Output</type><contentLength>1045191</contentLength><contentType>application/pdf</contentType><version>Version of Record</version><cronfaStatus>true</cronfaStatus><documentNotes>© 2024 The Authors. Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry. This is an open access article under the terms of the Creative Commons Attribution License.</documentNotes><copyrightCorrect>true</copyrightCorrect><language>eng</language><licence>http://creativecommons.org/licenses/by/4.0/</licence></document></documents><OutputDurs/></rfc1807>
spelling	2025-06-17T13:39:36.1152810 v2 69461 2025-05-08 Natural products from <i>Xenorhabdus</i> and <i>Photorhabdus</i> show promise as biolarvicides against <i>Aedes albopictus</i> 525f9e9af0d60813fdaee65dc0cb7cdf 0000-0002-9550-0782 Mustapha Touray Mustapha Touray true false 2025-05-08 BGPS BACKGROUND: In the perpetual struggle to manage mosquito populations, there has been increasing demand for the development of biopesticides to supplant/complement current products. The insecticidal potential of Xenorhabdus and Photorhabdus has long been recognized and is of interest for the control of important mosquitoes like Aedes albopictus which vectors over 20 different arboviruses of global public health concern. RESULTS: The larvicidal effects of cell-free supernatants, cell growth cultures and cell mass of an extensive list of Xenorhabdus and Photorhabdus spp. was investigated. They were quite effective against Ae. albopictus causing larval mortality ranging between 52–100%. Three Photorhabdus spp. and 13 Xenorhabdus spp. release larvicidal compounds in cell-free supernatants. Cell growth culture of all tested species exhibited larvicidal activity, except for Xenorhabdus sp. TS4. Twenty-one Xenorhabdus and Photorhabdus bacterial cells (pellet) exhibited oral toxicity (59–91%) against exposed larvae. The effect of bacterial supernatants on the mosquito eggs were also assessed. Bacterial supernatants inhibited the hatching of mosquito eggs; when unhatched eggs were transferred to clean water, they all hatched. Using the easyPACId approach, the larvicidal compounds in bacterial supernatant were identified as fabclavine from X. szentirmaii and xencoumacin from X. nematophila (causing 98 and 70% mortality, respectively, after 48 h). Xenorhabdus cabanillasii and X. hominickii fabclavines were as effective as commercial Bacillus thuringiensis subsp. israelensis and spinosad products within 5 days post-application (dpa). CONCLUSION: Fabclavine and xenocoumacin can be developed into novel biolarvicides, can be used as a model to synthesize other compounds or/and can be combined with other commercial biolarvicides. Journal Article Pest Management Science 80 9 4231 4242 Wiley 1526-498X 1526-4998 Aedes albopictus, larvicidal, Xenorhabdus, Photorhabdus, fabclavine, xenocoumacin 1 9 2024 2024-09-01 10.1002/ps.8127 COLLEGE NANME Biosciences Geography and Physics School COLLEGE CODE BGPS Swansea University Another institution paid the OA fee Türkiye Bilimsel ve Teknolojik Araştırma Kurumu. Grant Number: TUBITAK-116Z074; European Research Council. Grant Number: 835108; LOEWE-Centre Translational Biodiversity Genomics (TBG) of the State of Hesse; Aydin Adnan Menderes University. Grant Number: FEF-22014 2025-06-17T13:39:36.1152810 2025-05-08T22:46:26.8870969 Faculty of Science and Engineering School of Biosciences, Geography and Physics - Biosciences Mustapha Touray 0000-0002-9550-0782 1 Derya Ulug 2 Sebnem Hazal Gulsen 3 Harun Cimen 4 Canan Hazir 5 Helge B. Bode 6 Selcuk Hazir 7 69461__34495__81be37e5128442c99bcc706ce9539838.pdf 69461.VOR.pdf 2025-06-17T13:37:23.3219766 Output 1045191 application/pdf Version of Record true © 2024 The Authors. Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry. This is an open access article under the terms of the Creative Commons Attribution License. true eng http://creativecommons.org/licenses/by/4.0/
title	Natural products from <i>Xenorhabdus</i> and <i>Photorhabdus</i> show promise as biolarvicides against <i>Aedes albopictus</i>
spellingShingle	Natural products from <i>Xenorhabdus</i> and <i>Photorhabdus</i> show promise as biolarvicides against <i>Aedes albopictus</i> Mustapha Touray
title_short	Natural products from <i>Xenorhabdus</i> and <i>Photorhabdus</i> show promise as biolarvicides against <i>Aedes albopictus</i>
title_full	Natural products from <i>Xenorhabdus</i> and <i>Photorhabdus</i> show promise as biolarvicides against <i>Aedes albopictus</i>
title_fullStr	Natural products from <i>Xenorhabdus</i> and <i>Photorhabdus</i> show promise as biolarvicides against <i>Aedes albopictus</i>
title_full_unstemmed	Natural products from <i>Xenorhabdus</i> and <i>Photorhabdus</i> show promise as biolarvicides against <i>Aedes albopictus</i>
title_sort	Natural products from <i>Xenorhabdus</i> and <i>Photorhabdus</i> show promise as biolarvicides against <i>Aedes albopictus</i>
author_id_str_mv	525f9e9af0d60813fdaee65dc0cb7cdf
author_id_fullname_str_mv	525f9e9af0d60813fdaee65dc0cb7cdf_***_Mustapha Touray
author	Mustapha Touray
author2	Mustapha Touray Derya Ulug Sebnem Hazal Gulsen Harun Cimen Canan Hazir Helge B. Bode Selcuk Hazir
format	Journal article
container_title	Pest Management Science
container_volume	80
container_issue	9
container_start_page	4231
publishDate	2024
institution	Swansea University
issn	1526-498X 1526-4998
doi_str_mv	10.1002/ps.8127
publisher	Wiley
college_str	Faculty of Science and Engineering
hierarchytype
hierarchy_top_id	facultyofscienceandengineering
hierarchy_top_title	Faculty of Science and Engineering
hierarchy_parent_id	facultyofscienceandengineering
hierarchy_parent_title	Faculty of Science and Engineering
department_str	School of Biosciences, Geography and Physics - Biosciences{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Biosciences, Geography and Physics - Biosciences
document_store_str	1
active_str	0
description	BACKGROUND: In the perpetual struggle to manage mosquito populations, there has been increasing demand for the development of biopesticides to supplant/complement current products. The insecticidal potential of Xenorhabdus and Photorhabdus has long been recognized and is of interest for the control of important mosquitoes like Aedes albopictus which vectors over 20 different arboviruses of global public health concern. RESULTS: The larvicidal effects of cell-free supernatants, cell growth cultures and cell mass of an extensive list of Xenorhabdus and Photorhabdus spp. was investigated. They were quite effective against Ae. albopictus causing larval mortality ranging between 52–100%. Three Photorhabdus spp. and 13 Xenorhabdus spp. release larvicidal compounds in cell-free supernatants. Cell growth culture of all tested species exhibited larvicidal activity, except for Xenorhabdus sp. TS4. Twenty-one Xenorhabdus and Photorhabdus bacterial cells (pellet) exhibited oral toxicity (59–91%) against exposed larvae. The effect of bacterial supernatants on the mosquito eggs were also assessed. Bacterial supernatants inhibited the hatching of mosquito eggs; when unhatched eggs were transferred to clean water, they all hatched. Using the easyPACId approach, the larvicidal compounds in bacterial supernatant were identified as fabclavine from X. szentirmaii and xencoumacin from X. nematophila (causing 98 and 70% mortality, respectively, after 48 h). Xenorhabdus cabanillasii and X. hominickii fabclavines were as effective as commercial Bacillus thuringiensis subsp. israelensis and spinosad products within 5 days post-application (dpa). CONCLUSION: Fabclavine and xenocoumacin can be developed into novel biolarvicides, can be used as a model to synthesize other compounds or/and can be combined with other commercial biolarvicides.
published_date	2024-09-01T07:38:58Z
_version_	1850743706079985664
score	11.08895

Natural products from <i>Xenorhabdus</i> and <i>Photorhabdus</i> show promise as biolarvicides against <i>Aedes albopictus</i>

Similar Items