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VR READY: a protocol for a non-randomised, single-arm, mixed methods, feasibility trial of a coproduced ViRtual REality intervention to AiD recoverY in people recently admitted to intensive care

Cheney J G Drew Orcid Logo, Kim Smallman, Sarah Gill, Craig Greenstock, Katherine Cullen Orcid Logo, Alys Irving, Paul Twose Orcid Logo, Ceri Battle Orcid Logo, Domonic White, Michelle Smalley, Ceri Lynch

BMJ Open, Volume: 15, Issue: 8, Start page: e102688

Swansea University Author: Katherine Cullen Orcid Logo

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DOI (Published version): 10.1136/bmjopen-2025-102688

Abstract

Introduction: Post-intensive care syndrome (PICS) describes a cluster of ongoing symptoms experienced by a large proportion of patients previously admitted to critical care. Despite a large rise in survival following critical care, interventions to support recovery and combat PICS are lacking. It ha...

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Published in: BMJ Open
ISSN: 2044-6055 2044-6055
Published: BMJ Publishing Group 2025
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URI: https://cronfa.swan.ac.uk/Record/cronfa70179
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last_indexed 2025-08-14T05:40:06Z
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spelling 2025-08-13T11:20:23.0873016 v2 70179 2025-08-13 VR READY: a protocol for a non-randomised, single-arm, mixed methods, feasibility trial of a coproduced ViRtual REality intervention to AiD recoverY in people recently admitted to intensive care 9ddf9fac6330356b51fbb9f38fd6081f 0000-0002-3704-4598 Katherine Cullen Katherine Cullen true false 2025-08-13 HSOC Introduction: Post-intensive care syndrome (PICS) describes a cluster of ongoing symptoms experienced by a large proportion of patients previously admitted to critical care. Despite a large rise in survival following critical care, interventions to support recovery and combat PICS are lacking. It has been suggested that the use of digital tools such as virtual reality (VR) may play a useful role in the development of recovery-supporting interventions. We engaged with people with lived experience of critical care admission to coproduce a VR intervention (ViRtual REality to AiD recoverY post ICU (VR READY)). Here, we present a protocol for the initial feasibility and acceptability testing of this intervention. Methods and analysis: This is a single-arm, single-site, non-randomised feasibility trial of VR READY. Up to 25 participants recently admitted to critical care will be recruited to use the VR READY intervention for at least 5 min per day for a period of 14 days. Participants must have capacity to consent and be free from ongoing delirium in order to participate. Outcomes relating to sleep and well-being will be measured at baseline and at day 14 after intervention delivery. The primary outcome is feasibility, which will be assessed according to prespecified criteria. Participants will complete a qualitative interview to assess acceptability of the intervention, trial design and outcomes approximately 1 month after completing the intervention period. No formal statistical analysis of outcomes will be conducted, but these will be summarised descriptively. Interviews will be subjected to reflexive thematic analysis. Ethics and dissemination: This study received a favourable ethical opinion by North-East York Research Ethics Committee (Ref 23/NE/0113) in June 2024. Study results will be disseminated through the peer review literature, ISRCTN registry and directly to participants, which will be facilitated by the study public and patient involvement steering group. Trial registration number: ISRCTN88854487. Journal Article BMJ Open 15 8 e102688 BMJ Publishing Group 2044-6055 2044-6055 12 8 2025 2025-08-12 10.1136/bmjopen-2025-102688 Protocol COLLEGE NANME Health and Social Care School COLLEGE CODE HSOC Swansea University Another institution paid the OA fee This work was funded by Health Care Research Wales (Research for Public and Patient Benefit, Ref RfPPB-21-1870(P)). 2025-08-13T11:20:23.0873016 2025-08-13T11:10:07.9488899 Faculty of Medicine, Health and Life Sciences School of Health and Social Care - Public Health Cheney J G Drew 0000-0002-4397-6252 1 Kim Smallman 2 Sarah Gill 3 Craig Greenstock 4 Katherine Cullen 0000-0002-3704-4598 5 Alys Irving 6 Paul Twose 0000-0002-5468-2903 7 Ceri Battle 0000-0002-7503-1931 8 Domonic White 9 Michelle Smalley 10 Ceri Lynch 11 70179__34947__343340751f7e4d809bb9b3f991848df5.pdf bmjopen-2025-102688.pdf 2025-08-13T11:10:07.7679508 Output 651385 application/pdf Version of Record true © Author(s) (or their employer(s)) 2025. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license. true eng http://creativecommons.org/licenses/by-nc/4.0/
title VR READY: a protocol for a non-randomised, single-arm, mixed methods, feasibility trial of a coproduced ViRtual REality intervention to AiD recoverY in people recently admitted to intensive care
spellingShingle VR READY: a protocol for a non-randomised, single-arm, mixed methods, feasibility trial of a coproduced ViRtual REality intervention to AiD recoverY in people recently admitted to intensive care
Katherine Cullen
title_short VR READY: a protocol for a non-randomised, single-arm, mixed methods, feasibility trial of a coproduced ViRtual REality intervention to AiD recoverY in people recently admitted to intensive care
title_full VR READY: a protocol for a non-randomised, single-arm, mixed methods, feasibility trial of a coproduced ViRtual REality intervention to AiD recoverY in people recently admitted to intensive care
title_fullStr VR READY: a protocol for a non-randomised, single-arm, mixed methods, feasibility trial of a coproduced ViRtual REality intervention to AiD recoverY in people recently admitted to intensive care
title_full_unstemmed VR READY: a protocol for a non-randomised, single-arm, mixed methods, feasibility trial of a coproduced ViRtual REality intervention to AiD recoverY in people recently admitted to intensive care
title_sort VR READY: a protocol for a non-randomised, single-arm, mixed methods, feasibility trial of a coproduced ViRtual REality intervention to AiD recoverY in people recently admitted to intensive care
author_id_str_mv 9ddf9fac6330356b51fbb9f38fd6081f
author_id_fullname_str_mv 9ddf9fac6330356b51fbb9f38fd6081f_***_Katherine Cullen
author Katherine Cullen
author2 Cheney J G Drew
Kim Smallman
Sarah Gill
Craig Greenstock
Katherine Cullen
Alys Irving
Paul Twose
Ceri Battle
Domonic White
Michelle Smalley
Ceri Lynch
format Journal article
container_title BMJ Open
container_volume 15
container_issue 8
container_start_page e102688
publishDate 2025
institution Swansea University
issn 2044-6055
2044-6055
doi_str_mv 10.1136/bmjopen-2025-102688
publisher BMJ Publishing Group
college_str Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str School of Health and Social Care - Public Health{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}School of Health and Social Care - Public Health
document_store_str 1
active_str 0
description Introduction: Post-intensive care syndrome (PICS) describes a cluster of ongoing symptoms experienced by a large proportion of patients previously admitted to critical care. Despite a large rise in survival following critical care, interventions to support recovery and combat PICS are lacking. It has been suggested that the use of digital tools such as virtual reality (VR) may play a useful role in the development of recovery-supporting interventions. We engaged with people with lived experience of critical care admission to coproduce a VR intervention (ViRtual REality to AiD recoverY post ICU (VR READY)). Here, we present a protocol for the initial feasibility and acceptability testing of this intervention. Methods and analysis: This is a single-arm, single-site, non-randomised feasibility trial of VR READY. Up to 25 participants recently admitted to critical care will be recruited to use the VR READY intervention for at least 5 min per day for a period of 14 days. Participants must have capacity to consent and be free from ongoing delirium in order to participate. Outcomes relating to sleep and well-being will be measured at baseline and at day 14 after intervention delivery. The primary outcome is feasibility, which will be assessed according to prespecified criteria. Participants will complete a qualitative interview to assess acceptability of the intervention, trial design and outcomes approximately 1 month after completing the intervention period. No formal statistical analysis of outcomes will be conducted, but these will be summarised descriptively. Interviews will be subjected to reflexive thematic analysis. Ethics and dissemination: This study received a favourable ethical opinion by North-East York Research Ethics Committee (Ref 23/NE/0113) in June 2024. Study results will be disseminated through the peer review literature, ISRCTN registry and directly to participants, which will be facilitated by the study public and patient involvement steering group. Trial registration number: ISRCTN88854487.
published_date 2025-08-12T07:48:35Z
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