How to get physiologically relevant data with students using <i>Lumbriculus variegatus</i>

Seeley, Aidan; Corns, Laura F.; Rouse, James L.; Freestone, Nicholas S.

doi:10.1152/advan.00084.2025

Journal article 404 views 48 downloads

How to get physiologically relevant data with students using <i>Lumbriculus variegatus</i>

Aidan Seeley

, Laura F. Corns

, James L. Rouse

, Nicholas S. Freestone

Advances in Physiology Education, Volume: 49, Issue: 4, Pages: 934 - 942

Swansea University Author: Aidan Seeley

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DOI (Published version): 10.1152/advan.00084.2025

Abstract

The decline of in vivo teaching in higher education has resulted in graduates lacking essential experimental skills. To address this gap, we present an easy and cost-effective practical class using the emerging invertebrate model organism Lumbriculus variegatus as an additional in vivo model for edu...

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Published in:	Advances in Physiology Education
ISSN:	1043-4046 1522-1229
Published:	American Physiological Society 2025
Online Access:	Check full text
URI:	https://cronfa.swan.ac.uk/Record/cronfa70318

first_indexed	2025-09-07T16:01:34Z
last_indexed	2025-10-21T06:06:17Z
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spelling	2025-10-20T16:18:06.3190681 v2 70318 2025-09-07 How to get physiologically relevant data with students using <i>Lumbriculus variegatus</i> c69dba86b3ccf9a140b67b7e97d68bba 0000-0001-7085-4296 Aidan Seeley Aidan Seeley true false 2025-09-07 MEDS The decline of in vivo teaching in higher education has resulted in graduates lacking essential experimental skills. To address this gap, we present an easy and cost-effective practical class using the emerging invertebrate model organism Lumbriculus variegatus as an additional in vivo model for education. This practical class enables students to observe the effects of pharmacologically active compounds on the stereotypical behaviors of body reversal and helical swimming in L. variegatus through tactile stimulation. During this class, students will conduct drug dilution calculations, administer test compounds, and conduct an in vivo behavioral experiment. Results from this class demonstrate drug effects in vivo and enable students to observe reversible or irreversible behavioral effects, depending on the compound tested. This class demonstrates L. variegatus as a model for hands-on in vivo teaching, providing students with critical laboratory experience without the need for vertebrate or higher-order mammal models. Furthermore, the approach outlined here is scalable and an adaptable teaching methodology that enhances student engagement with in vivo teaching without costly equipment or complex animal husbandry. Journal Article Advances in Physiology Education 49 4 934 942 American Physiological Society 1043-4046 1522-1229 Lumbriculus variegatus; partial replacement; 3Rs; undergraduate experiments 1 12 2025 2025-12-01 10.1152/advan.00084.2025 COLLEGE NANME Medical School COLLEGE CODE MEDS Swansea University Other This work is supported by the British Pharmacological Society’s Education Grant 2019 and 2021. 2025-10-20T16:18:06.3190681 2025-09-07T12:42:42.5971448 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Biomedical Science Aidan Seeley 0000-0001-7085-4296 1 Laura F. Corns 0000-0003-1139-3527 2 James L. Rouse 0000-0001-8457-4623 3 Nicholas S. Freestone 0009-0002-8626-7904 4 70318__35419__34da53eaa7e44c47ba5b5ee56383dcbe.pdf 70318.VoR.pdf 2025-10-20T16:05:04.6889177 Output 1018134 application/pdf Version of Record true Copyright © 2025 The Authors. Licensed under Creative Commons Attribution CC-BY-NC 4.0. true eng https://creativecommons.org/licenses/by-nc/4.0/
title	How to get physiologically relevant data with students using <i>Lumbriculus variegatus</i>
spellingShingle	How to get physiologically relevant data with students using <i>Lumbriculus variegatus</i> Aidan Seeley
title_short	How to get physiologically relevant data with students using <i>Lumbriculus variegatus</i>
title_full	How to get physiologically relevant data with students using <i>Lumbriculus variegatus</i>
title_fullStr	How to get physiologically relevant data with students using <i>Lumbriculus variegatus</i>
title_full_unstemmed	How to get physiologically relevant data with students using <i>Lumbriculus variegatus</i>
title_sort	How to get physiologically relevant data with students using <i>Lumbriculus variegatus</i>
author_id_str_mv	c69dba86b3ccf9a140b67b7e97d68bba
author_id_fullname_str_mv	c69dba86b3ccf9a140b67b7e97d68bba_***_Aidan Seeley
author	Aidan Seeley
author2	Aidan Seeley Laura F. Corns James L. Rouse Nicholas S. Freestone
format	Journal article
container_title	Advances in Physiology Education
container_volume	49
container_issue	4
container_start_page	934
publishDate	2025
institution	Swansea University
issn	1043-4046 1522-1229
doi_str_mv	10.1152/advan.00084.2025
publisher	American Physiological Society
college_str	Faculty of Medicine, Health and Life Sciences
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hierarchy_top_title	Faculty of Medicine, Health and Life Sciences
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hierarchy_parent_title	Faculty of Medicine, Health and Life Sciences
department_str	Swansea University Medical School - Biomedical Science{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Biomedical Science
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description	The decline of in vivo teaching in higher education has resulted in graduates lacking essential experimental skills. To address this gap, we present an easy and cost-effective practical class using the emerging invertebrate model organism Lumbriculus variegatus as an additional in vivo model for education. This practical class enables students to observe the effects of pharmacologically active compounds on the stereotypical behaviors of body reversal and helical swimming in L. variegatus through tactile stimulation. During this class, students will conduct drug dilution calculations, administer test compounds, and conduct an in vivo behavioral experiment. Results from this class demonstrate drug effects in vivo and enable students to observe reversible or irreversible behavioral effects, depending on the compound tested. This class demonstrates L. variegatus as a model for hands-on in vivo teaching, providing students with critical laboratory experience without the need for vertebrate or higher-order mammal models. Furthermore, the approach outlined here is scalable and an adaptable teaching methodology that enhances student engagement with in vivo teaching without costly equipment or complex animal husbandry.
published_date	2025-12-01T05:31:08Z
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How to get physiologically relevant data with students using <i>Lumbriculus variegatus</i>

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