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Journal article

An old worm with new tricks? The applications for Lumbriculus variegatus as an invertebrate model for education

Aidan Seeley Orcid Logo

Current Opinion in Physiology, Start page: 100928

Swansea University Author: Aidan Seeley Orcid Logo

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Abstract

Lumbriculus variegatus is an aquatic worm which has gained recent renewed interest as a practical model for biomedical education, enabling in vivo behavioural, physiological, toxicological, and biochemical responses to biologically active compounds to be assessed in educational settings. As inverteb...

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Published in: Current Opinion in Physiology
ISSN: 2468-8673
Published: Elsevier BV 2026
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URI: https://cronfa.swan.ac.uk/Record/cronfa71494
Abstract: Lumbriculus variegatus is an aquatic worm which has gained recent renewed interest as a practical model for biomedical education, enabling in vivo behavioural, physiological, toxicological, and biochemical responses to biologically active compounds to be assessed in educational settings. As invertebrates, L. variegatus offers easy integration into educational settings without regulatory constraints, and this positions L. variegatus as a valuable tool for practical in vivo learning. This review provides an overview of methodologies utilised within studies of L. variegatus, including toxicity, locomotive behavioural assays, measurement of dorsal blood vessel pulsation, metabolic profiling, and molecular endpoints, and describes their current and potential applications within educational settings.
College: Faculty of Medicine, Health and Life Sciences
Start Page: 100928