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An old worm with new tricks? The applications for Lumbriculus variegatus as an invertebrate model for education

Aidan Seeley Orcid Logo

Current Opinion in Physiology, Start page: 100928

Swansea University Author: Aidan Seeley Orcid Logo

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DOI (Published version): 10.1016/j.cophys.2026.100928

Abstract

Lumbriculus variegatus is an aquatic worm which has gained recent renewed interest as a practical model for biomedical education, enabling in vivo behavioural, physiological, toxicological, and biochemical responses to biologically active compounds to be assessed in educational settings. As inverteb...

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Published in: Current Opinion in Physiology
ISSN: 2468-8673
Published: Elsevier BV 2026
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URI: https://cronfa.swan.ac.uk/Record/cronfa71494
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spelling v2 71494 2026-02-25 An old worm with new tricks? The applications for Lumbriculus variegatus as an invertebrate model for education c69dba86b3ccf9a140b67b7e97d68bba 0000-0001-7085-4296 Aidan Seeley Aidan Seeley true false 2026-02-25 MEDS Lumbriculus variegatus is an aquatic worm which has gained recent renewed interest as a practical model for biomedical education, enabling in vivo behavioural, physiological, toxicological, and biochemical responses to biologically active compounds to be assessed in educational settings. As invertebrates, L. variegatus offers easy integration into educational settings without regulatory constraints, and this positions L. variegatus as a valuable tool for practical in vivo learning. This review provides an overview of methodologies utilised within studies of L. variegatus, including toxicity, locomotive behavioural assays, measurement of dorsal blood vessel pulsation, metabolic profiling, and molecular endpoints, and describes their current and potential applications within educational settings. Journal Article Current Opinion in Physiology 100928 Elsevier BV 2468-8673 9 2 2026 2026-02-09 10.1016/j.cophys.2026.100928 https://doi.org/10.1016/j.cophys.2026.100928 COLLEGE NANME Medical School COLLEGE CODE MEDS Swansea University Other 2026-02-25T10:43:17.4782170 2026-02-25T10:23:11.5228640 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Biomedical Science Aidan Seeley 0000-0001-7085-4296 1
title An old worm with new tricks? The applications for Lumbriculus variegatus as an invertebrate model for education
spellingShingle An old worm with new tricks? The applications for Lumbriculus variegatus as an invertebrate model for education
Aidan Seeley
title_short An old worm with new tricks? The applications for Lumbriculus variegatus as an invertebrate model for education
title_full An old worm with new tricks? The applications for Lumbriculus variegatus as an invertebrate model for education
title_fullStr An old worm with new tricks? The applications for Lumbriculus variegatus as an invertebrate model for education
title_full_unstemmed An old worm with new tricks? The applications for Lumbriculus variegatus as an invertebrate model for education
title_sort An old worm with new tricks? The applications for Lumbriculus variegatus as an invertebrate model for education
author_id_str_mv c69dba86b3ccf9a140b67b7e97d68bba
author_id_fullname_str_mv c69dba86b3ccf9a140b67b7e97d68bba_***_Aidan Seeley
author Aidan Seeley
author2 Aidan Seeley
format Journal article
container_title Current Opinion in Physiology
container_start_page 100928
publishDate 2026
institution Swansea University
issn 2468-8673
doi_str_mv 10.1016/j.cophys.2026.100928
publisher Elsevier BV
college_str Faculty of Medicine, Health and Life Sciences
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hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str Swansea University Medical School - Biomedical Science{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Biomedical Science
url https://doi.org/10.1016/j.cophys.2026.100928
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description Lumbriculus variegatus is an aquatic worm which has gained recent renewed interest as a practical model for biomedical education, enabling in vivo behavioural, physiological, toxicological, and biochemical responses to biologically active compounds to be assessed in educational settings. As invertebrates, L. variegatus offers easy integration into educational settings without regulatory constraints, and this positions L. variegatus as a valuable tool for practical in vivo learning. This review provides an overview of methodologies utilised within studies of L. variegatus, including toxicity, locomotive behavioural assays, measurement of dorsal blood vessel pulsation, metabolic profiling, and molecular endpoints, and describes their current and potential applications within educational settings.
published_date 2026-02-09T10:43:18Z
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