Journal article 240 views 53 downloads
Platelets sequester extracellular DNA, capturing tumor-derived and free fetal DNA
Lauren Murphy 
,
Jeanne Inchauspé ,
Giampiero Valenzano ,
Pamela Holland ,
Nikolaos Sousos ,
Hayley L. Belnoue-Davis,
Rong Li ,
Natalie J. Jooss ,
Camelia Benlabiod ,
Eleanor Murphy,
Zohar Etzioni ,
Emelie Shepherd,
Lucy Denly ,
Sujata Biswas ,
Lin Chen,
Jennifer O’Sullivan ,
Michael P. Rimmer ,
Abdullah O. Khan ,
Christina Simoglou Karali ,
Nadia Nasreddin ,
Ian S. Hitchcock ,
Milka Koupenova ,
Skirmantas Kriaucionis ,
Jim R. Hughes,
Eric O’Neill ,
Manu Vatish ,
Paul Rees ,
Simon Leedham ,
Michael Desborough ,
Adam J. Mead ,
Benjamin Schuster-Böckler ,
Christopher D. Gregory ,
Bethan Psaila
,
Jeanne Inchauspé ,
Giampiero Valenzano ,
Pamela Holland ,
Nikolaos Sousos ,
Hayley L. Belnoue-Davis,
Rong Li ,
Natalie J. Jooss ,
Camelia Benlabiod ,
Eleanor Murphy,
Zohar Etzioni ,
Emelie Shepherd,
Lucy Denly ,
Sujata Biswas ,
Lin Chen,
Jennifer O’Sullivan ,
Michael P. Rimmer ,
Abdullah O. Khan ,
Christina Simoglou Karali ,
Nadia Nasreddin ,
Ian S. Hitchcock ,
Milka Koupenova ,
Skirmantas Kriaucionis ,
Jim R. Hughes,
Eric O’Neill ,
Manu Vatish ,
Paul Rees ,
Simon Leedham ,
Michael Desborough ,
Adam J. Mead ,
Benjamin Schuster-Böckler ,
Christopher D. Gregory ,
Bethan Psaila
Science, Volume: 389, Issue: 6761
Swansea University Author:
Paul Rees
-
PDF | Accepted Manuscript
Author accepted manuscript document released under the terms of a Creative Commons CC-BY licence using the Swansea University Research Publications Policy (rights retention).
Download (22.45MB)
DOI (Published version): 10.1126/science.adp3971
Abstract
Platelets sequester extracellular DNA, capturing tumor-derived and free fetal DNA
| Published in: | Science |
|---|---|
| ISSN: | 0036-8075 1095-9203 |
| Published: |
American Association for the Advancement of Science (AAAS)
2025
|
| Online Access: |
Check full text
|
| URI: | https://cronfa.swan.ac.uk/Record/cronfa70325 |
| first_indexed |
2025-09-11T16:01:42Z |
|---|---|
| last_indexed |
2025-10-24T07:55:41Z |
| id |
cronfa70325 |
| recordtype |
SURis |
| fullrecord |
<?xml version="1.0"?><rfc1807><datestamp>2025-10-22T15:04:38.8166142</datestamp><bib-version>v2</bib-version><id>70325</id><entry>2025-09-11</entry><title>Platelets sequester extracellular DNA, capturing tumor-derived and free fetal DNA</title><swanseaauthors><author><sid>537a2fe031a796a3bde99679ee8c24f5</sid><ORCID>0000-0002-7715-6914</ORCID><firstname>Paul</firstname><surname>Rees</surname><name>Paul Rees</name><active>true</active><ethesisStudent>false</ethesisStudent></author></swanseaauthors><date>2025-09-11</date><deptcode>EAAS</deptcode><abstract/><type>Journal Article</type><journal>Science</journal><volume>389</volume><journalNumber>6761</journalNumber><paginationStart/><paginationEnd/><publisher>American Association for the Advancement of Science (AAAS)</publisher><placeOfPublication/><isbnPrint/><isbnElectronic/><issnPrint>0036-8075</issnPrint><issnElectronic>1095-9203</issnElectronic><keywords/><publishedDay>14</publishedDay><publishedMonth>8</publishedMonth><publishedYear>2025</publishedYear><publishedDate>2025-08-14</publishedDate><doi>10.1126/science.adp3971</doi><url/><notes/><college>COLLEGE NANME</college><department>Engineering and Applied Sciences School</department><CollegeCode>COLLEGE CODE</CollegeCode><DepartmentCode>EAAS</DepartmentCode><institution>Swansea University</institution><apcterm>Not Required</apcterm><funders>Funding was provided by Cancer Research UK Early Detection Project Grant EDDCPJT/100003 (B.P., C.D.G., P.R.); CRUK Advanced Clinical Scientist Fellowship C67633/A29034 (B.P.); Senior Fellowship RCCSCF-May24/100001 funded by Cancer Research UK in partnership with the Rosetrees Trust (B.P.); Ludwig Institute for Cancer Research Associate Member Program (B.P., B.S.-B.); Medical Research Council Grant MR/T04490X/1 (B.S.-B.); Kidani Memorial Trust (E.O.N.); CRUK Oxford Centre Clinical Research Training Fellowship C130623/A249471 (N.S.); and an unrestricted research grant from Emerson Health (now Yosemite) (B.P.). We also acknowledge support from the National Institute for Health Research (NIHR), Oxford Biomedical Research Centre (BRC), and CRUK Oxford Centre Grant CTRQQR-2021\100002.</funders><projectreference/><lastEdited>2025-10-22T15:04:38.8166142</lastEdited><Created>2025-09-11T09:42:13.7495272</Created><path><level id="1">Faculty of Science and Engineering</level><level id="2">School of Engineering and Applied Sciences - Biomedical Engineering</level></path><authors><author><firstname>Lauren</firstname><surname>Murphy</surname><orcid>0000-0001-9506-2762</orcid><order>1</order></author><author><firstname>Jeanne</firstname><surname>Inchauspé</surname><orcid>0000-0003-4489-423x</orcid><order>2</order></author><author><firstname>Giampiero</firstname><surname>Valenzano</surname><orcid>0009-0000-4882-4066</orcid><order>3</order></author><author><firstname>Pamela</firstname><surname>Holland</surname><orcid>0009-0008-8265-9808</orcid><order>4</order></author><author><firstname>Nikolaos</firstname><surname>Sousos</surname><orcid>0000-0002-9100-2954</orcid><order>5</order></author><author><firstname>Hayley L.</firstname><surname>Belnoue-Davis</surname><order>6</order></author><author><firstname>Rong</firstname><surname>Li</surname><orcid>0000-0002-1805-810x</orcid><order>7</order></author><author><firstname>Natalie J.</firstname><surname>Jooss</surname><orcid>0000-0002-2314-4993</orcid><order>8</order></author><author><firstname>Camelia</firstname><surname>Benlabiod</surname><orcid>0000-0001-7119-9326</orcid><order>9</order></author><author><firstname>Eleanor</firstname><surname>Murphy</surname><order>10</order></author><author><firstname>Zohar</firstname><surname>Etzioni</surname><orcid>0000-0002-7172-4036</orcid><order>11</order></author><author><firstname>Emelie</firstname><surname>Shepherd</surname><order>12</order></author><author><firstname>Lucy</firstname><surname>Denly</surname><orcid>0000-0001-9915-4760</orcid><order>13</order></author><author><firstname>Sujata</firstname><surname>Biswas</surname><orcid>0000-0002-0700-7286</orcid><order>14</order></author><author><firstname>Lin</firstname><surname>Chen</surname><order>15</order></author><author><firstname>Jennifer</firstname><surname>O’Sullivan</surname><orcid>0000-0003-0502-7133</orcid><order>16</order></author><author><firstname>Michael P.</firstname><surname>Rimmer</surname><orcid>0000-0002-3295-8753</orcid><order>17</order></author><author><firstname>Abdullah O.</firstname><surname>Khan</surname><orcid>0000-0003-0825-3179</orcid><order>18</order></author><author><firstname>Christina Simoglou</firstname><surname>Karali</surname><orcid>0000-0003-2169-6580</orcid><order>19</order></author><author><firstname>Nadia</firstname><surname>Nasreddin</surname><orcid>0000-0002-3025-6213</orcid><order>20</order></author><author><firstname>Ian S.</firstname><surname>Hitchcock</surname><orcid>0000-0001-7170-6703</orcid><order>21</order></author><author><firstname>Milka</firstname><surname>Koupenova</surname><orcid>0000-0001-5934-8990</orcid><order>22</order></author><author><firstname>Skirmantas</firstname><surname>Kriaucionis</surname><orcid>0000-0002-2273-5994</orcid><order>23</order></author><author><firstname>Jim R.</firstname><surname>Hughes</surname><order>24</order></author><author><firstname>Eric</firstname><surname>O’Neill</surname><orcid>0000-0002-0060-6278</orcid><order>25</order></author><author><firstname>Manu</firstname><surname>Vatish</surname><orcid>0000-0002-6012-2574</orcid><order>26</order></author><author><firstname>Paul</firstname><surname>Rees</surname><orcid>0000-0002-7715-6914</orcid><order>27</order></author><author><firstname>Simon</firstname><surname>Leedham</surname><orcid>0000-0003-1476-6982</orcid><order>28</order></author><author><firstname>Michael</firstname><surname>Desborough</surname><orcid>0000-0002-1951-5616</orcid><order>29</order></author><author><firstname>Adam J.</firstname><surname>Mead</surname><orcid>0000-0001-8522-1002</orcid><order>30</order></author><author><firstname>Benjamin</firstname><surname>Schuster-Böckler</surname><orcid>0000-0002-8892-5133</orcid><order>31</order></author><author><firstname>Christopher D.</firstname><surname>Gregory</surname><orcid>0000-0002-7553-0132</orcid><order>32</order></author><author><firstname>Bethan</firstname><surname>Psaila</surname><orcid>0000-0001-8198-9663</orcid><order>33</order></author></authors><documents><document><filename>70325__35095__9b1833ee77cb47978151b1ed575ada5c.pdf</filename><originalFilename>Science_Paper_Main_Text_and_Figs_Paul_Rees.pdf</originalFilename><uploaded>2025-09-16T13:32:27.1580320</uploaded><type>Output</type><contentLength>23545065</contentLength><contentType>application/pdf</contentType><version>Accepted Manuscript</version><cronfaStatus>true</cronfaStatus><documentNotes>Author accepted manuscript document released under the terms of a Creative Commons CC-BY licence using the Swansea University Research Publications Policy (rights retention).</documentNotes><copyrightCorrect>true</copyrightCorrect><language>eng</language><licence>https://creativecommons.org/licenses/by/4.0/deed.en</licence></document></documents><OutputDurs/></rfc1807> |
| spelling |
2025-10-22T15:04:38.8166142 v2 70325 2025-09-11 Platelets sequester extracellular DNA, capturing tumor-derived and free fetal DNA 537a2fe031a796a3bde99679ee8c24f5 0000-0002-7715-6914 Paul Rees Paul Rees true false 2025-09-11 EAAS Journal Article Science 389 6761 American Association for the Advancement of Science (AAAS) 0036-8075 1095-9203 14 8 2025 2025-08-14 10.1126/science.adp3971 COLLEGE NANME Engineering and Applied Sciences School COLLEGE CODE EAAS Swansea University Not Required Funding was provided by Cancer Research UK Early Detection Project Grant EDDCPJT/100003 (B.P., C.D.G., P.R.); CRUK Advanced Clinical Scientist Fellowship C67633/A29034 (B.P.); Senior Fellowship RCCSCF-May24/100001 funded by Cancer Research UK in partnership with the Rosetrees Trust (B.P.); Ludwig Institute for Cancer Research Associate Member Program (B.P., B.S.-B.); Medical Research Council Grant MR/T04490X/1 (B.S.-B.); Kidani Memorial Trust (E.O.N.); CRUK Oxford Centre Clinical Research Training Fellowship C130623/A249471 (N.S.); and an unrestricted research grant from Emerson Health (now Yosemite) (B.P.). We also acknowledge support from the National Institute for Health Research (NIHR), Oxford Biomedical Research Centre (BRC), and CRUK Oxford Centre Grant CTRQQR-2021\100002. 2025-10-22T15:04:38.8166142 2025-09-11T09:42:13.7495272 Faculty of Science and Engineering School of Engineering and Applied Sciences - Biomedical Engineering Lauren Murphy 0000-0001-9506-2762 1 Jeanne Inchauspé 0000-0003-4489-423x 2 Giampiero Valenzano 0009-0000-4882-4066 3 Pamela Holland 0009-0008-8265-9808 4 Nikolaos Sousos 0000-0002-9100-2954 5 Hayley L. Belnoue-Davis 6 Rong Li 0000-0002-1805-810x 7 Natalie J. Jooss 0000-0002-2314-4993 8 Camelia Benlabiod 0000-0001-7119-9326 9 Eleanor Murphy 10 Zohar Etzioni 0000-0002-7172-4036 11 Emelie Shepherd 12 Lucy Denly 0000-0001-9915-4760 13 Sujata Biswas 0000-0002-0700-7286 14 Lin Chen 15 Jennifer O’Sullivan 0000-0003-0502-7133 16 Michael P. Rimmer 0000-0002-3295-8753 17 Abdullah O. Khan 0000-0003-0825-3179 18 Christina Simoglou Karali 0000-0003-2169-6580 19 Nadia Nasreddin 0000-0002-3025-6213 20 Ian S. Hitchcock 0000-0001-7170-6703 21 Milka Koupenova 0000-0001-5934-8990 22 Skirmantas Kriaucionis 0000-0002-2273-5994 23 Jim R. Hughes 24 Eric O’Neill 0000-0002-0060-6278 25 Manu Vatish 0000-0002-6012-2574 26 Paul Rees 0000-0002-7715-6914 27 Simon Leedham 0000-0003-1476-6982 28 Michael Desborough 0000-0002-1951-5616 29 Adam J. Mead 0000-0001-8522-1002 30 Benjamin Schuster-Böckler 0000-0002-8892-5133 31 Christopher D. Gregory 0000-0002-7553-0132 32 Bethan Psaila 0000-0001-8198-9663 33 70325__35095__9b1833ee77cb47978151b1ed575ada5c.pdf Science_Paper_Main_Text_and_Figs_Paul_Rees.pdf 2025-09-16T13:32:27.1580320 Output 23545065 application/pdf Accepted Manuscript true Author accepted manuscript document released under the terms of a Creative Commons CC-BY licence using the Swansea University Research Publications Policy (rights retention). true eng https://creativecommons.org/licenses/by/4.0/deed.en |
| title |
Platelets sequester extracellular DNA, capturing tumor-derived and free fetal DNA |
| spellingShingle |
Platelets sequester extracellular DNA, capturing tumor-derived and free fetal DNA Paul Rees |
| title_short |
Platelets sequester extracellular DNA, capturing tumor-derived and free fetal DNA |
| title_full |
Platelets sequester extracellular DNA, capturing tumor-derived and free fetal DNA |
| title_fullStr |
Platelets sequester extracellular DNA, capturing tumor-derived and free fetal DNA |
| title_full_unstemmed |
Platelets sequester extracellular DNA, capturing tumor-derived and free fetal DNA |
| title_sort |
Platelets sequester extracellular DNA, capturing tumor-derived and free fetal DNA |
| author_id_str_mv |
537a2fe031a796a3bde99679ee8c24f5 |
| author_id_fullname_str_mv |
537a2fe031a796a3bde99679ee8c24f5_***_Paul Rees |
| author |
Paul Rees |
| author2 |
Lauren Murphy Jeanne Inchauspé Giampiero Valenzano Pamela Holland Nikolaos Sousos Hayley L. Belnoue-Davis Rong Li Natalie J. Jooss Camelia Benlabiod Eleanor Murphy Zohar Etzioni Emelie Shepherd Lucy Denly Sujata Biswas Lin Chen Jennifer O’Sullivan Michael P. Rimmer Abdullah O. Khan Christina Simoglou Karali Nadia Nasreddin Ian S. Hitchcock Milka Koupenova Skirmantas Kriaucionis Jim R. Hughes Eric O’Neill Manu Vatish Paul Rees Simon Leedham Michael Desborough Adam J. Mead Benjamin Schuster-Böckler Christopher D. Gregory Bethan Psaila |
| format |
Journal article |
| container_title |
Science |
| container_volume |
389 |
| container_issue |
6761 |
| publishDate |
2025 |
| institution |
Swansea University |
| issn |
0036-8075 1095-9203 |
| doi_str_mv |
10.1126/science.adp3971 |
| publisher |
American Association for the Advancement of Science (AAAS) |
| college_str |
Faculty of Science and Engineering |
| hierarchytype |
|
| hierarchy_top_id |
facultyofscienceandengineering |
| hierarchy_top_title |
Faculty of Science and Engineering |
| hierarchy_parent_id |
facultyofscienceandengineering |
| hierarchy_parent_title |
Faculty of Science and Engineering |
| department_str |
School of Engineering and Applied Sciences - Biomedical Engineering{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Engineering and Applied Sciences - Biomedical Engineering |
| document_store_str |
1 |
| active_str |
0 |
| published_date |
2025-08-14T05:32:32Z |
| _version_ |
1857439926510944256 |
| score |
11.461559 |