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Hyperthermia and Rigidity Following Overdose of an Unknown Drug; A Case Report and Literature Review
Rose Cecile Dean-Paccagnella,
Matthew Creed,
Mahendra Kakollu,
Suresh Gopala Pillai 
Bulletin of Emergency and Trauma, Volume: 6, Issue: 3, Pages: 249 - 252
Swansea University Author:
Suresh Gopala Pillai
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Abstract
Drug induced hyperthermia is a rare presentation which can rapidly lead to gross metabolic abnormality and death. These presentations are further complicated by the wide range of potentially causative agents. We present a case of rigidity and hyperthermia, following overdose of an initially unknown...
| Published in: | Bulletin of Emergency and Trauma |
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| ISSN: | 2322-3960 2322-2522 |
| Published: |
Armenian Green Publishing Co.
2018
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| Online Access: |
Check full text
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| URI: | https://cronfa.swan.ac.uk/Record/cronfa70783 |
| Abstract: |
Drug induced hyperthermia is a rare presentation which can rapidly lead to gross metabolic abnormality and death. These presentations are further complicated by the wide range of potentially causative agents. We present a case of rigidity and hyperthermia, following overdose of an initially unknown substance leading to challenging management decisions in the Emergency Department. This case was later identified as Serotonin Syndrome. The patient presented with trismus which was managed with rapid sequence induction of anaesthesia to allow airway protection. On extubation a significant degree of laryngeal oedema complicated weaning, a possible complication of Serotonin Syndrome not previously described in the literature. We discuss the pathophysiology of Serotonin Syndrome, important differentials and practical considerations in managing hypertonicity of unknown origin in a young person. |
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| Item Description: |
https://beat.sums.ac.ir/article_44443.html |
| Keywords: |
Serotonin syndrome; Overdose; Hyperthermia; Hypertonicity |
| College: |
Faculty of Medicine, Health and Life Sciences |
| Issue: |
3 |
| Start Page: |
249 |
| End Page: |
252 |