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Hyperthermia and Rigidity Following Overdose of an Unknown Drug; A Case Report and Literature Review

Rose Cecile Dean-Paccagnella, Matthew Creed, Mahendra Kakollu, Suresh Gopala Pillai Orcid Logo

Bulletin of Emergency and Trauma, Volume: 6, Issue: 3, Pages: 249 - 252

Swansea University Author: Suresh Gopala Pillai Orcid Logo

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Abstract

Drug induced hyperthermia is a rare presentation which can rapidly lead to gross metabolic abnormality and death. These presentations are further complicated by the wide range of potentially causative agents. We present a case of rigidity and hyperthermia, following overdose of an initially unknown...

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Published in: Bulletin of Emergency and Trauma
ISSN: 2322-3960 2322-2522
Published: Armenian Green Publishing Co. 2018
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URI: https://cronfa.swan.ac.uk/Record/cronfa70783
first_indexed 2025-10-28T16:01:36Z
last_indexed 2025-11-14T06:47:43Z
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spelling 2025-11-12T16:05:45.6996567 v2 70783 2025-10-28 Hyperthermia and Rigidity Following Overdose of an Unknown Drug; A Case Report and Literature Review f567f8d5db61d62ef08e811676fd8430 0000-0002-9753-6949 Suresh Gopala Pillai Suresh Gopala Pillai true false 2025-10-28 MEDS Drug induced hyperthermia is a rare presentation which can rapidly lead to gross metabolic abnormality and death. These presentations are further complicated by the wide range of potentially causative agents. We present a case of rigidity and hyperthermia, following overdose of an initially unknown substance leading to challenging management decisions in the Emergency Department. This case was later identified as Serotonin Syndrome. The patient presented with trismus which was managed with rapid sequence induction of anaesthesia to allow airway protection. On extubation a significant degree of laryngeal oedema complicated weaning, a possible complication of Serotonin Syndrome not previously described in the literature. We discuss the pathophysiology of Serotonin Syndrome, important differentials and practical considerations in managing hypertonicity of unknown origin in a young person. Journal Article Bulletin of Emergency and Trauma 6 3 249 252 Armenian Green Publishing Co. 2322-3960 2322-2522 Serotonin syndrome; Overdose; Hyperthermia; Hypertonicity 1 6 2018 2018-06-01 https://beat.sums.ac.ir/article_44443.html https://beat.sums.ac.ir/article_44443.html COLLEGE NANME Medical School COLLEGE CODE MEDS Swansea University 2025-11-12T16:05:45.6996567 2025-10-28T09:40:51.6579683 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Biomedical Science Rose Cecile Dean-Paccagnella 1 Matthew Creed 2 Mahendra Kakollu 3 Suresh Gopala Pillai 0000-0002-9753-6949 4 70783__35611__a5ba276daa5c4759a0455385b3a13077.pdf 70783.VoR.pdf 2025-11-12T15:57:54.3733852 Output 528813 application/pdf Version of Record true This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. true eng http://creativecommons.org/licenses/by-nc/4.0/
title Hyperthermia and Rigidity Following Overdose of an Unknown Drug; A Case Report and Literature Review
spellingShingle Hyperthermia and Rigidity Following Overdose of an Unknown Drug; A Case Report and Literature Review
Suresh Gopala Pillai
title_short Hyperthermia and Rigidity Following Overdose of an Unknown Drug; A Case Report and Literature Review
title_full Hyperthermia and Rigidity Following Overdose of an Unknown Drug; A Case Report and Literature Review
title_fullStr Hyperthermia and Rigidity Following Overdose of an Unknown Drug; A Case Report and Literature Review
title_full_unstemmed Hyperthermia and Rigidity Following Overdose of an Unknown Drug; A Case Report and Literature Review
title_sort Hyperthermia and Rigidity Following Overdose of an Unknown Drug; A Case Report and Literature Review
author_id_str_mv f567f8d5db61d62ef08e811676fd8430
author_id_fullname_str_mv f567f8d5db61d62ef08e811676fd8430_***_Suresh Gopala Pillai
author Suresh Gopala Pillai
author2 Rose Cecile Dean-Paccagnella
Matthew Creed
Mahendra Kakollu
Suresh Gopala Pillai
format Journal article
container_title Bulletin of Emergency and Trauma
container_volume 6
container_issue 3
container_start_page 249
publishDate 2018
institution Swansea University
issn 2322-3960
2322-2522
publisher Armenian Green Publishing Co.
college_str Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str Swansea University Medical School - Biomedical Science{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Biomedical Science
url https://beat.sums.ac.ir/article_44443.html
document_store_str 1
active_str 0
description Drug induced hyperthermia is a rare presentation which can rapidly lead to gross metabolic abnormality and death. These presentations are further complicated by the wide range of potentially causative agents. We present a case of rigidity and hyperthermia, following overdose of an initially unknown substance leading to challenging management decisions in the Emergency Department. This case was later identified as Serotonin Syndrome. The patient presented with trismus which was managed with rapid sequence induction of anaesthesia to allow airway protection. On extubation a significant degree of laryngeal oedema complicated weaning, a possible complication of Serotonin Syndrome not previously described in the literature. We discuss the pathophysiology of Serotonin Syndrome, important differentials and practical considerations in managing hypertonicity of unknown origin in a young person.
published_date 2018-06-01T05:32:21Z
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score 11.095945

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