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The effect of intranasal insulin on appetite and mood in women with and without obesity: an experimental medicine study
,
Abd A. Tahrani,
Jason M. Thomas ,
Michelle Lee ,
Manfred Hallschmid ,
Pia Rotshtein,
Colin T. Dourish ,
Suzanne Higgs
International Journal of Obesity, Volume: 46, Issue: 7, Pages: 1319 - 1327
Swansea University Author:
Michelle Lee
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DOI (Published version): 10.1038/s41366-022-01115-1
Abstract
Background/Objectives: Intranasal (IN) administration of insulin decreases appetite in humans, but the underlying mechanisms are unclear, and it is unknown whether IN insulin affects the food intake of women with obesity. Subjects/Methods: In a double-blind, placebo-controlled, crossover design, par...
| Published in: | International Journal of Obesity |
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| ISSN: | 0307-0565 1476-5497 |
| Published: |
Springer Nature
2022
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| Online Access: |
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| URI: | https://cronfa.swan.ac.uk/Record/cronfa70850 |
| Abstract: |
Background/Objectives: Intranasal (IN) administration of insulin decreases appetite in humans, but the underlying mechanisms are unclear, and it is unknown whether IN insulin affects the food intake of women with obesity. Subjects/Methods: In a double-blind, placebo-controlled, crossover design, participants (35 lean women and 17 women with obesity) were randomized to receive 160 IU/1.6 mL of IN insulin or placebo in a counterbalanced order in the post prandial state. The effects of IN insulin on cookie intake, appetite, mood, food reward, cognition and neural activity were assessed. Results: IN insulin in the post prandial state reduced cookie intake, appetite and food reward relative to placebo and these effects were more pronounced for women with obesity compared with lean women. IN insulin also improved mood in women with obesity. In both BMI groups, IN insulin increased neural activity in the insula when viewing food pictures. IN insulin did not affect cognitive function. Conclusions: These results suggest that IN insulin decreases palatable food intake when satiated by reducing food reward and that women with obesity may be more sensitive to this effect than lean women. Further investigation of the therapeutic potential of IN insulin for weight management in women with obesity is warranted. |
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| College: |
Faculty of Medicine, Health and Life Sciences |
| Funders: |
Funding for this work was provided by BBSRC Grant UK awarded to SH grant number: BB/N008847/1 and supported by the NIHR funded Birmingham Clinical Research Facility. |
| Issue: |
7 |
| Start Page: |
1319 |
| End Page: |
1327 |