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The effect of intranasal insulin on appetite and mood in women with and without obesity: an experimental medicine study

Elizabeth Schneider, Maartje S. Spetter, Elizabeth Martin, Elizabeth Sapey, Kay Por Yip, Konstantinos N. Manolopoulos Orcid Logo, Abd A. Tahrani, Jason M. Thomas Orcid Logo, Michelle Lee Orcid Logo, Manfred Hallschmid Orcid Logo, Pia Rotshtein, Colin T. Dourish Orcid Logo, Suzanne Higgs Orcid Logo

International Journal of Obesity, Volume: 46, Issue: 7, Pages: 1319 - 1327

Swansea University Author: Michelle Lee Orcid Logo

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DOI (Published version): 10.1038/s41366-022-01115-1

Abstract

Background/Objectives: Intranasal (IN) administration of insulin decreases appetite in humans, but the underlying mechanisms are unclear, and it is unknown whether IN insulin affects the food intake of women with obesity. Subjects/Methods: In a double-blind, placebo-controlled, crossover design, par...

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Published in: International Journal of Obesity
ISSN: 0307-0565 1476-5497
Published: Springer Nature 2022
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URI: https://cronfa.swan.ac.uk/Record/cronfa70850
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Subjects/Methods: In a double-blind, placebo-controlled, crossover design, participants (35 lean women and 17 women with obesity) were randomized to receive 160 IU/1.6 mL of IN insulin or placebo in a counterbalanced order in the post prandial state. The effects of IN insulin on cookie intake, appetite, mood, food reward, cognition and neural activity were assessed. Results: IN insulin in the post prandial state reduced cookie intake, appetite and food reward relative to placebo and these effects were more pronounced for women with obesity compared with lean women. IN insulin also improved mood in women with obesity. In both BMI groups, IN insulin increased neural activity in the insula when viewing food pictures. IN insulin did not affect cognitive function. Conclusions: These results suggest that IN insulin decreases palatable food intake when satiated by reducing food reward and that women with obesity may be more sensitive to this effect than lean women. 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spelling 2025-12-01T15:17:29.0293590 v2 70850 2025-11-06 The effect of intranasal insulin on appetite and mood in women with and without obesity: an experimental medicine study 503d8657d47c066ada31f344b030c352 0000-0002-1291-5895 Michelle Lee Michelle Lee true false 2025-11-06 PSYS Background/Objectives: Intranasal (IN) administration of insulin decreases appetite in humans, but the underlying mechanisms are unclear, and it is unknown whether IN insulin affects the food intake of women with obesity. Subjects/Methods: In a double-blind, placebo-controlled, crossover design, participants (35 lean women and 17 women with obesity) were randomized to receive 160 IU/1.6 mL of IN insulin or placebo in a counterbalanced order in the post prandial state. The effects of IN insulin on cookie intake, appetite, mood, food reward, cognition and neural activity were assessed. Results: IN insulin in the post prandial state reduced cookie intake, appetite and food reward relative to placebo and these effects were more pronounced for women with obesity compared with lean women. IN insulin also improved mood in women with obesity. In both BMI groups, IN insulin increased neural activity in the insula when viewing food pictures. IN insulin did not affect cognitive function. Conclusions: These results suggest that IN insulin decreases palatable food intake when satiated by reducing food reward and that women with obesity may be more sensitive to this effect than lean women. Further investigation of the therapeutic potential of IN insulin for weight management in women with obesity is warranted. Journal Article International Journal of Obesity 46 7 1319 1327 Springer Nature 0307-0565 1476-5497 1 7 2022 2022-07-01 10.1038/s41366-022-01115-1 COLLEGE NANME Psychology School COLLEGE CODE PSYS Swansea University External research funder(s) paid the OA fee (includes OA grants disbursed by the Library) Funding for this work was provided by BBSRC Grant UK awarded to SH grant number: BB/N008847/1 and supported by the NIHR funded Birmingham Clinical Research Facility. 2025-12-01T15:17:29.0293590 2025-11-06T13:31:40.9683730 Faculty of Medicine, Health and Life Sciences School of Psychology Elizabeth Schneider 1 Maartje S. Spetter 2 Elizabeth Martin 3 Elizabeth Sapey 4 Kay Por Yip 5 Konstantinos N. Manolopoulos 0000-0001-8890-6090 6 Abd A. Tahrani 7 Jason M. Thomas 0000-0001-7013-8994 8 Michelle Lee 0000-0002-1291-5895 9 Manfred Hallschmid 0000-0002-0352-1106 10 Pia Rotshtein 11 Colin T. Dourish 0000-0002-3403-6330 12 Suzanne Higgs 0000-0002-9225-7692 13 70850__35723__b8d4c3862e5c4bc7b4d42c0a376665d1.pdf 70850.VOR.pdf 2025-12-01T15:15:22.9188861 Output 2161769 application/pdf Version of Record true © The Author(s) 2022. This article is licensed under a Creative Commons Attribution 4.0 International License. true eng http://creativecommons.org/licenses/by/4.0/
title The effect of intranasal insulin on appetite and mood in women with and without obesity: an experimental medicine study
spellingShingle The effect of intranasal insulin on appetite and mood in women with and without obesity: an experimental medicine study
Michelle Lee
title_short The effect of intranasal insulin on appetite and mood in women with and without obesity: an experimental medicine study
title_full The effect of intranasal insulin on appetite and mood in women with and without obesity: an experimental medicine study
title_fullStr The effect of intranasal insulin on appetite and mood in women with and without obesity: an experimental medicine study
title_full_unstemmed The effect of intranasal insulin on appetite and mood in women with and without obesity: an experimental medicine study
title_sort The effect of intranasal insulin on appetite and mood in women with and without obesity: an experimental medicine study
author_id_str_mv 503d8657d47c066ada31f344b030c352
author_id_fullname_str_mv 503d8657d47c066ada31f344b030c352_***_Michelle Lee
author Michelle Lee
author2 Elizabeth Schneider
Maartje S. Spetter
Elizabeth Martin
Elizabeth Sapey
Kay Por Yip
Konstantinos N. Manolopoulos
Abd A. Tahrani
Jason M. Thomas
Michelle Lee
Manfred Hallschmid
Pia Rotshtein
Colin T. Dourish
Suzanne Higgs
format Journal article
container_title International Journal of Obesity
container_volume 46
container_issue 7
container_start_page 1319
publishDate 2022
institution Swansea University
issn 0307-0565
1476-5497
doi_str_mv 10.1038/s41366-022-01115-1
publisher Springer Nature
college_str Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str School of Psychology{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}School of Psychology
document_store_str 1
active_str 0
description Background/Objectives: Intranasal (IN) administration of insulin decreases appetite in humans, but the underlying mechanisms are unclear, and it is unknown whether IN insulin affects the food intake of women with obesity. Subjects/Methods: In a double-blind, placebo-controlled, crossover design, participants (35 lean women and 17 women with obesity) were randomized to receive 160 IU/1.6 mL of IN insulin or placebo in a counterbalanced order in the post prandial state. The effects of IN insulin on cookie intake, appetite, mood, food reward, cognition and neural activity were assessed. Results: IN insulin in the post prandial state reduced cookie intake, appetite and food reward relative to placebo and these effects were more pronounced for women with obesity compared with lean women. IN insulin also improved mood in women with obesity. In both BMI groups, IN insulin increased neural activity in the insula when viewing food pictures. IN insulin did not affect cognitive function. Conclusions: These results suggest that IN insulin decreases palatable food intake when satiated by reducing food reward and that women with obesity may be more sensitive to this effect than lean women. Further investigation of the therapeutic potential of IN insulin for weight management in women with obesity is warranted.
published_date 2022-07-01T05:28:16Z
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