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Educational attainment of children with self-limited epilepsy with CentroTemporal spikes (SELECTS), other epilepsies, and without epilepsy: A retrospective cohort study

Arron Lacey Orcid Logo, Carys Jones, Christopher J Weir Orcid Logo, Jacqueline Stephen Orcid Logo, Owen Pickrell Orcid Logo, Richard F Chin Orcid Logo

Seizure: European Journal of Epilepsy, Volume: 134, Pages: 134 - 138

Swansea University Authors: Arron Lacey Orcid Logo, Carys Jones, Owen Pickrell Orcid Logo

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DOI (Published version): 10.1016/j.seizure.2025.11.009

Abstract

Background: Children with epilepsy may have poorer educational outcomes—this may not be true for all epilepsy syndromes. We investigate educational attainment of children with Self-Limited Epilepsy with CentroTemporal Spikes (SELECTS) in Wales. Method: A retrospective cohort study using routinely-co...

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Published in: Seizure: European Journal of Epilepsy
ISSN: 1059-1311 1532-2688
Published: Elsevier BV 2026
Online Access: Check full text

URI: https://cronfa.swan.ac.uk/Record/cronfa70882
Abstract: Background: Children with epilepsy may have poorer educational outcomes—this may not be true for all epilepsy syndromes. We investigate educational attainment of children with Self-Limited Epilepsy with CentroTemporal Spikes (SELECTS) in Wales. Method: A retrospective cohort study using routinely-collected data for children in Wales. We used primary care diagnosis codes to identify children (0–16 years) with SELECTS, other epilepsies, and children without epilepsy (comparators). We linked these records to Key Stage (KS) 2, 3 and 4 (ages 11,14, and 16) national educational test results (2003–2021). We performed logistic regression to analyse attainment (proportion achieving required attainment) in children with SELECTS, other epilepsies, and comparators. Results: At KS 2,3 and 4: 101,92 and 81 children with SELECTS were matched to 299,274 and 243 children with other epilepsies and comparators. A lower proportion of the SELECTS and other epilepsies groups achieved required attainment than the comparators across all key stages.After adjusting for sex, deprivation, year of study and Anti-Seizure Medications (ASM), children with SELECTS had similar achievement to comparators in KS2 and KS3:adjusted Odds Ratio (aOR,[95 %CI]) for achieving requirement:KS2:aOR=0.97[0.87–1.09];KS3:aOR=0.99[0.88–1.10]; but slightly reduced KS4 achievement:aOR=0.89,[0.80–1.00]. Children with other epilepsies were significantly less likely to achieve the requirement than comparators:KS2:aOR=0.79[0.72–0.87], KS3:aOR=0.78[0.71–0.86],KS4:aOR=0.72[0.65–0.80]. Conclusions: There was a trend for poorer educational achievement for children with SELECTS at KS4; this was only borderline statistically significant in the adjusted model. Children with other epilepsies had an increased risk of poorer attainment across all ages when compared to children without epilepsy.
Keywords: Epilepsy; Self-limited epilepsy with centrotemporal spikes (SELECTS); Educational attainment; Children; Routinely-collected data; Rolandic epilepsy; Childhood epilepsy with centrotemporal spikes (CECTS)
College: Faculty of Medicine, Health and Life Sciences
Funders: This work was supported by the Waterloo Foundation.
Start Page: 134
End Page: 138

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