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Distinct H3K27 Methylation States Drive Cellular Responses to the Histone Demethylase Inhibitor GSK-J4 in Ovarian Cancer Cells

Marcos Quintela Orcid Logo, Lydia Powell Orcid Logo, Agne Baseviciene, David W. James Orcid Logo, David Howard, Natalia Sikora, Jordan Turney, Neil S. Garton Orcid Logo, Lavinia Margarit, Amy Beynon, Inmaculada Rioja Orcid Logo, Rab K. Prinjha Orcid Logo, Nicola R. Harker Orcid Logo, Deya Gonzalez Orcid Logo, Steve Conlan Orcid Logo, Lewis Francis Orcid Logo

Molecular Cancer Therapeutics, Pages: OF1 - OF13

Swansea University Authors: Lydia Powell Orcid Logo, Agne Baseviciene, David Howard, Natalia Sikora, Jordan Turney, Lavinia Margarit, Amy Beynon, Deya Gonzalez Orcid Logo, Steve Conlan Orcid Logo, Lewis Francis Orcid Logo

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DOI (Published version): 10.1158/1535-7163.mct-25-0268

Published in: Molecular Cancer Therapeutics
ISSN: 1535-7163 1538-8514
Published: American Association for Cancer Research (AACR) 2026
Online Access: Check full text

URI: https://cronfa.swan.ac.uk/Record/cronfa71846
first_indexed 2026-05-01T09:01:10Z
last_indexed 2026-06-25T06:25:17Z
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spelling v2 71846 2026-05-01 Distinct H3K27 Methylation States Drive Cellular Responses to the Histone Demethylase Inhibitor GSK-J4 in Ovarian Cancer Cells 0e7e702952672bcbfdfd4974199202fb 0000-0002-8641-0160 Lydia Powell Lydia Powell true false 84c6725e2bf8941faae8ed66821732fd Agne Baseviciene Agne Baseviciene true false c7c303f6cb3c54c8f7ed2563c1a39759 David Howard David Howard true false b1e78a2c42b22116548c19230406d9b5 Natalia Sikora Natalia Sikora true false ad072d60784f297ef2ff04e8cd59f0f1 Jordan Turney Jordan Turney true false 1cdeff800fa264ed1424b0d86c587c67 Lavinia Margarit Lavinia Margarit true false aefec476b7e8ca62f99c89dabd4bdf80 Amy Beynon Amy Beynon true false bafdf635eb81280304eedf4b18e65d4e 0000-0002-1838-6752 Deya Gonzalez Deya Gonzalez true false 0bb6bd247e32fb4249de62c0013b51cb 0000-0002-2562-3461 Steve Conlan Steve Conlan true false 10f61f9c1248951c1a33f6a89498f37d 0000-0002-7803-7714 Lewis Francis Lewis Francis true false 2026-05-01 MEDS Journal Article Molecular Cancer Therapeutics 0 OF1 OF13 American Association for Cancer Research (AACR) 1535-7163 1538-8514 Histone methylation, H3K27 demethylases, ovarian cancer, GSK-J4, androgen receptor 27 4 2026 2026-04-27 10.1158/1535-7163.mct-25-0268 COLLEGE NANME Medical School COLLEGE CODE MEDS Swansea University Not Required The research conducted herein was funded by SMARTExpertise programmes CEAT and RISE via the Welsh Government and the European Regional Development Fund (2017/COL/004; 2017/COL/001), and supported by Genomics Partnership Wales. 2026-07-08T15:36:00.0133547 2026-05-01T09:57:25.4607864 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Biomedical Science Marcos Quintela 0000-0002-9628-695x 1 Lydia Powell 0000-0002-8641-0160 2 Agne Baseviciene 3 David W. James 0000-0003-3951-9187 4 David Howard 5 Natalia Sikora 6 Jordan Turney 7 Neil S. Garton 0000-0001-6853-5616 8 Lavinia Margarit 9 Amy Beynon 10 Inmaculada Rioja 0000-0002-0533-2253 11 Rab K. Prinjha 0000-0002-2666-3326 12 Nicola R. Harker 0000-0003-3612-4366 13 Deya Gonzalez 0000-0002-1838-6752 14 Steve Conlan 0000-0002-2562-3461 15 Lewis Francis 0000-0002-7803-7714 16 71846__37173__0c23fd496c28417b9dd2de085fc4f204.pdf 71846.AAM.pdf 2026-07-08T15:29:53.7583128 Output 6854045 application/pdf Accepted Manuscript true Author accepted manuscript document released under the terms of a Creative Commons CC-BY licence using the Swansea University Research Publications Policy (rights retention). true eng https://creativecommons.org/licenses/by/4.0/
title Distinct H3K27 Methylation States Drive Cellular Responses to the Histone Demethylase Inhibitor GSK-J4 in Ovarian Cancer Cells
spellingShingle Distinct H3K27 Methylation States Drive Cellular Responses to the Histone Demethylase Inhibitor GSK-J4 in Ovarian Cancer Cells
Lydia Powell
Agne Baseviciene
David Howard
Natalia Sikora
Jordan Turney
Lavinia Margarit
Amy Beynon
Deya Gonzalez
Steve Conlan
Lewis Francis
title_short Distinct H3K27 Methylation States Drive Cellular Responses to the Histone Demethylase Inhibitor GSK-J4 in Ovarian Cancer Cells
title_full Distinct H3K27 Methylation States Drive Cellular Responses to the Histone Demethylase Inhibitor GSK-J4 in Ovarian Cancer Cells
title_fullStr Distinct H3K27 Methylation States Drive Cellular Responses to the Histone Demethylase Inhibitor GSK-J4 in Ovarian Cancer Cells
title_full_unstemmed Distinct H3K27 Methylation States Drive Cellular Responses to the Histone Demethylase Inhibitor GSK-J4 in Ovarian Cancer Cells
title_sort Distinct H3K27 Methylation States Drive Cellular Responses to the Histone Demethylase Inhibitor GSK-J4 in Ovarian Cancer Cells
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author_id_fullname_str_mv 0e7e702952672bcbfdfd4974199202fb_***_Lydia Powell
84c6725e2bf8941faae8ed66821732fd_***_Agne Baseviciene
c7c303f6cb3c54c8f7ed2563c1a39759_***_David Howard
b1e78a2c42b22116548c19230406d9b5_***_Natalia Sikora
ad072d60784f297ef2ff04e8cd59f0f1_***_Jordan Turney
1cdeff800fa264ed1424b0d86c587c67_***_Lavinia Margarit
aefec476b7e8ca62f99c89dabd4bdf80_***_Amy Beynon
bafdf635eb81280304eedf4b18e65d4e_***_Deya Gonzalez
0bb6bd247e32fb4249de62c0013b51cb_***_Steve Conlan
10f61f9c1248951c1a33f6a89498f37d_***_Lewis Francis
author Lydia Powell
Agne Baseviciene
David Howard
Natalia Sikora
Jordan Turney
Lavinia Margarit
Amy Beynon
Deya Gonzalez
Steve Conlan
Lewis Francis
author2 Marcos Quintela
Lydia Powell
Agne Baseviciene
David W. James
David Howard
Natalia Sikora
Jordan Turney
Neil S. Garton
Lavinia Margarit
Amy Beynon
Inmaculada Rioja
Rab K. Prinjha
Nicola R. Harker
Deya Gonzalez
Steve Conlan
Lewis Francis
format Journal article
container_title Molecular Cancer Therapeutics
container_volume 0
container_start_page OF1
publishDate 2026
institution Swansea University
issn 1535-7163
1538-8514
doi_str_mv 10.1158/1535-7163.mct-25-0268
publisher American Association for Cancer Research (AACR)
college_str Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str Swansea University Medical School - Biomedical Science{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Biomedical Science
document_store_str 1
active_str 0
published_date 2026-04-27T15:36:02Z
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score 10.951308

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