Journal article 1083 views
Event related potential (ERP) evidence for selective impairment of verbal recollection in abstinent recreational methylenedioxymethamphetamine (“Ecstasy”)/polydrug users
Adrian P Burgess,
Louise Venables,
Helena Jones,
Rhiannon Edwards,
Andrew Parrott
Psychopharmacology, Volume: 216, Issue: 4, Pages: 545 - 556
Swansea University Author: Andrew Parrott
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DOI (Published version): 10.1007/s00213-011-2249-9
Abstract
Ecstasy is a recreational drug whose active ingredient, 3,4 Methylenedioxymethamphetamine (MDMA), acts predominantly on the serotonergic system. Although MDMA is known to be neurotoxic in animals, the long-term effects of recreational Ecstasy use in humans remain controversial but one commonly repor...
Published in: | Psychopharmacology |
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ISSN: | 0033-3158 1432-2072 |
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2011
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URI: | https://cronfa.swan.ac.uk/Record/cronfa9309 |
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2015-05-14T15:54:28.9002015 v2 9309 2012-03-19 Event related potential (ERP) evidence for selective impairment of verbal recollection in abstinent recreational methylenedioxymethamphetamine (“Ecstasy”)/polydrug users 3c706e6f0763eeaf11b0cc8b37d6757f Andrew Parrott Andrew Parrott true false 2012-03-19 HPS Ecstasy is a recreational drug whose active ingredient, 3,4 Methylenedioxymethamphetamine (MDMA), acts predominantly on the serotonergic system. Although MDMA is known to be neurotoxic in animals, the long-term effects of recreational Ecstasy use in humans remain controversial but one commonly reported consequence is mild cognitive impairment particularly affecting verbal episodic memory. Although event-related potentials (ERPs) have made significant contributions to our understanding of human memory processes, until now they have not been applied to study the long term effects of Ecstasy. The aim of this study was to examine the effects of past Ecstasy use on recognition memory for both verbal and non-verbal stimuli using ERPs. We compared the ERPs of abstinent Ecstasy usersEcstasy/polydrug users with those of matched groups of cannabis users and non-drug using controls. Despite equivalent memory performance, Ecstasy usersEcstasy/polydrug users showed an attenuated late positivity over left-parietal scalp sites, a component associated with the specific memory process of recollection. This effect was only found in the word recognition task which is consistent with evidence that left hemisphere cognitive functions are disproportionately affected by Ecstasy, probably because the serotonergic system is laterally asymmetrical. Experimentally decreasing central serotonergic activity through acute tryptophan depletion also selectively impairs recollection, and this too suggests the importance of the serotonergic system. Overall, our results suggest that Ecstasy has a durable effect on a specific component of recognition memory, recollection, and that this is most probably caused by the serotonergic neurotoxicity of MDMA although the role of other drugs cannot be excluded. Journal Article Psychopharmacology 216 4 545 556 0033-3158 1432-2072 31 8 2011 2011-08-31 10.1007/s00213-011-2249-9 COLLEGE NANME Psychology COLLEGE CODE HPS Swansea University 2015-05-14T15:54:28.9002015 2012-03-19T09:20:56.0019026 Faculty of Medicine, Health and Life Sciences School of Psychology Adrian P Burgess 1 Louise Venables 2 Helena Jones 3 Rhiannon Edwards 4 Andrew Parrott 5 |
title |
Event related potential (ERP) evidence for selective impairment of verbal recollection in abstinent recreational methylenedioxymethamphetamine (“Ecstasy”)/polydrug users |
spellingShingle |
Event related potential (ERP) evidence for selective impairment of verbal recollection in abstinent recreational methylenedioxymethamphetamine (“Ecstasy”)/polydrug users Andrew Parrott |
title_short |
Event related potential (ERP) evidence for selective impairment of verbal recollection in abstinent recreational methylenedioxymethamphetamine (“Ecstasy”)/polydrug users |
title_full |
Event related potential (ERP) evidence for selective impairment of verbal recollection in abstinent recreational methylenedioxymethamphetamine (“Ecstasy”)/polydrug users |
title_fullStr |
Event related potential (ERP) evidence for selective impairment of verbal recollection in abstinent recreational methylenedioxymethamphetamine (“Ecstasy”)/polydrug users |
title_full_unstemmed |
Event related potential (ERP) evidence for selective impairment of verbal recollection in abstinent recreational methylenedioxymethamphetamine (“Ecstasy”)/polydrug users |
title_sort |
Event related potential (ERP) evidence for selective impairment of verbal recollection in abstinent recreational methylenedioxymethamphetamine (“Ecstasy”)/polydrug users |
author_id_str_mv |
3c706e6f0763eeaf11b0cc8b37d6757f |
author_id_fullname_str_mv |
3c706e6f0763eeaf11b0cc8b37d6757f_***_Andrew Parrott |
author |
Andrew Parrott |
author2 |
Adrian P Burgess Louise Venables Helena Jones Rhiannon Edwards Andrew Parrott |
format |
Journal article |
container_title |
Psychopharmacology |
container_volume |
216 |
container_issue |
4 |
container_start_page |
545 |
publishDate |
2011 |
institution |
Swansea University |
issn |
0033-3158 1432-2072 |
doi_str_mv |
10.1007/s00213-011-2249-9 |
college_str |
Faculty of Medicine, Health and Life Sciences |
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|
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facultyofmedicinehealthandlifesciences |
hierarchy_top_title |
Faculty of Medicine, Health and Life Sciences |
hierarchy_parent_id |
facultyofmedicinehealthandlifesciences |
hierarchy_parent_title |
Faculty of Medicine, Health and Life Sciences |
department_str |
School of Psychology{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}School of Psychology |
document_store_str |
0 |
active_str |
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description |
Ecstasy is a recreational drug whose active ingredient, 3,4 Methylenedioxymethamphetamine (MDMA), acts predominantly on the serotonergic system. Although MDMA is known to be neurotoxic in animals, the long-term effects of recreational Ecstasy use in humans remain controversial but one commonly reported consequence is mild cognitive impairment particularly affecting verbal episodic memory. Although event-related potentials (ERPs) have made significant contributions to our understanding of human memory processes, until now they have not been applied to study the long term effects of Ecstasy. The aim of this study was to examine the effects of past Ecstasy use on recognition memory for both verbal and non-verbal stimuli using ERPs. We compared the ERPs of abstinent Ecstasy usersEcstasy/polydrug users with those of matched groups of cannabis users and non-drug using controls. Despite equivalent memory performance, Ecstasy usersEcstasy/polydrug users showed an attenuated late positivity over left-parietal scalp sites, a component associated with the specific memory process of recollection. This effect was only found in the word recognition task which is consistent with evidence that left hemisphere cognitive functions are disproportionately affected by Ecstasy, probably because the serotonergic system is laterally asymmetrical. Experimentally decreasing central serotonergic activity through acute tryptophan depletion also selectively impairs recollection, and this too suggests the importance of the serotonergic system. Overall, our results suggest that Ecstasy has a durable effect on a specific component of recognition memory, recollection, and that this is most probably caused by the serotonergic neurotoxicity of MDMA although the role of other drugs cannot be excluded. |
published_date |
2011-08-31T03:11:14Z |
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1763749998701314048 |
score |
11.021648 |