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MDMA and methamphetamine: some paradoxical negative and positive mood changes in an acute dose laboratory study

Andrew Parrott, Amy Gibbs, Andrew B Scholey, Rebecca King, Katherine Owens, Phil Swann, Ed Ogden, Con Stough

Psychopharmacology, Volume: 215, Issue: 3, Pages: 527 - 536

Swansea University Author: Andrew Parrott

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DOI (Published version): 10.1007/s00213-011-2184-9

Abstract

Rationale: to investigate the acute mood effects of oral Ecstasy/MDMA, methamphetamine, and placebo, in a double-blind laboratory study. Methods: 53 healthy participants comprised abstinent recreational users of stimulant drugs, both female and male, with a mean age around 25 years. The three test s...

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Published in: Psychopharmacology
ISSN: 0033-3158 1432-2072
Published: 2011
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URI: https://cronfa.swan.ac.uk/Record/cronfa9310
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spelling 2011-10-01T00:00:00.0000000 v2 9310 2012-03-19 MDMA and methamphetamine: some paradoxical negative and positive mood changes in an acute dose laboratory study 3c706e6f0763eeaf11b0cc8b37d6757f Andrew Parrott Andrew Parrott true false 2012-03-19 HPS Rationale: to investigate the acute mood effects of oral Ecstasy/MDMA, methamphetamine, and placebo, in a double-blind laboratory study. Methods: 53 healthy participants comprised abstinent recreational users of stimulant drugs, both female and male, with a mean age around 25 years. The three test sessions involved acute 100mg oral 3.4-methylendioxymethamphetamine (MDMA), 0.42mg/kg oral methamphetamine, and matching placebo. Drug administration was counterbalanced, testing was double-blind, and medical supervision was present throughout. Car driving performance on a laboratory simulator was assessed after 3 and 24 hours, with the findings being presented elsewhere. Positive and negative moods (PANAS self-ratings) were completed before drug administration, 3 hours, 4.5 hours, and 24 hours later. Blood samples were taken to monitor drug plasma levels.Results: Following MDMA there were no significant increases in positive moods, whereas negative moods were significantly higher than under placebo. Methamphetamine led to significant increases in both positive moods and negative moods. The MDMA findings contrast with the elated moods typically noted by dance clubbers on Ecstasy. However they are consistent with previous laboratory findings, where an array of positive and negative mood changes have been demonstrated. One possible explanatory factor was the neutral environmental situation, particularly if a primary action of MDMA is to intensify ongoing psychological states. Other explanatory factors, such as dosage, post-drug timing, neurohormonal influences, and social factors, are also discussed. Conclusions: In the laboratory acute methamphetamine led to significantly higher positive moods. However against expectations, MDMA did not generate a significant increase in positive moods. Journal Article Psychopharmacology 215 3 527 536 0033-3158 1432-2072 30 6 2011 2011-06-30 10.1007/s00213-011-2184-9 COLLEGE NANME Psychology COLLEGE CODE HPS Swansea University 2011-10-01T00:00:00.0000000 2012-03-19T09:26:47.0938077 Faculty of Medicine, Health and Life Sciences School of Psychology Andrew Parrott 1 Amy Gibbs 2 Andrew B Scholey 3 Rebecca King 4 Katherine Owens 5 Phil Swann 6 Ed Ogden 7 Con Stough 8
title MDMA and methamphetamine: some paradoxical negative and positive mood changes in an acute dose laboratory study
spellingShingle MDMA and methamphetamine: some paradoxical negative and positive mood changes in an acute dose laboratory study
Andrew Parrott
title_short MDMA and methamphetamine: some paradoxical negative and positive mood changes in an acute dose laboratory study
title_full MDMA and methamphetamine: some paradoxical negative and positive mood changes in an acute dose laboratory study
title_fullStr MDMA and methamphetamine: some paradoxical negative and positive mood changes in an acute dose laboratory study
title_full_unstemmed MDMA and methamphetamine: some paradoxical negative and positive mood changes in an acute dose laboratory study
title_sort MDMA and methamphetamine: some paradoxical negative and positive mood changes in an acute dose laboratory study
author_id_str_mv 3c706e6f0763eeaf11b0cc8b37d6757f
author_id_fullname_str_mv 3c706e6f0763eeaf11b0cc8b37d6757f_***_Andrew Parrott
author Andrew Parrott
author2 Andrew Parrott
Amy Gibbs
Andrew B Scholey
Rebecca King
Katherine Owens
Phil Swann
Ed Ogden
Con Stough
format Journal article
container_title Psychopharmacology
container_volume 215
container_issue 3
container_start_page 527
publishDate 2011
institution Swansea University
issn 0033-3158
1432-2072
doi_str_mv 10.1007/s00213-011-2184-9
college_str Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str School of Psychology{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}School of Psychology
document_store_str 0
active_str 0
description Rationale: to investigate the acute mood effects of oral Ecstasy/MDMA, methamphetamine, and placebo, in a double-blind laboratory study. Methods: 53 healthy participants comprised abstinent recreational users of stimulant drugs, both female and male, with a mean age around 25 years. The three test sessions involved acute 100mg oral 3.4-methylendioxymethamphetamine (MDMA), 0.42mg/kg oral methamphetamine, and matching placebo. Drug administration was counterbalanced, testing was double-blind, and medical supervision was present throughout. Car driving performance on a laboratory simulator was assessed after 3 and 24 hours, with the findings being presented elsewhere. Positive and negative moods (PANAS self-ratings) were completed before drug administration, 3 hours, 4.5 hours, and 24 hours later. Blood samples were taken to monitor drug plasma levels.Results: Following MDMA there were no significant increases in positive moods, whereas negative moods were significantly higher than under placebo. Methamphetamine led to significant increases in both positive moods and negative moods. The MDMA findings contrast with the elated moods typically noted by dance clubbers on Ecstasy. However they are consistent with previous laboratory findings, where an array of positive and negative mood changes have been demonstrated. One possible explanatory factor was the neutral environmental situation, particularly if a primary action of MDMA is to intensify ongoing psychological states. Other explanatory factors, such as dosage, post-drug timing, neurohormonal influences, and social factors, are also discussed. Conclusions: In the laboratory acute methamphetamine led to significantly higher positive moods. However against expectations, MDMA did not generate a significant increase in positive moods.
published_date 2011-06-30T03:11:14Z
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score 10.999524

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