Journal article 1215 views
Presymptomatic differences in Toll-like receptor function in infants who have allergy.
Journal of Allergy and Clinical Immunology, Volume: 122, Issue: 2, Pages: 391 - 399
Swansea University Author:
Cathy Thornton
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DOI (Published version): 10.1016/j.jaci.2008.04.042
Abstract
BACKGROUND: Microbial exposure might play a key role in allergy development, but little is known about the role of Toll-like receptors (TLRs).OBJECTIVE: This study explored the association between neonatal TLR microbial recognition/function, allergy risk (maternal allergy), and prospective allergy d...
Published in: | Journal of Allergy and Clinical Immunology |
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ISSN: | 00916749 |
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Elsevier
2008
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URI: | https://cronfa.swan.ac.uk/Record/cronfa9991 |
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<?xml version="1.0"?><rfc1807><datestamp>2013-11-08T11:15:03.4890358</datestamp><bib-version>v2</bib-version><id>9991</id><entry>2012-03-21</entry><title>Presymptomatic differences in Toll-like receptor function in infants who have allergy.</title><swanseaauthors><author><sid>c71a7a4be7361094d046d312202bce0c</sid><ORCID>0000-0002-5153-573X</ORCID><firstname>Cathy</firstname><surname>Thornton</surname><name>Cathy Thornton</name><active>true</active><ethesisStudent>false</ethesisStudent></author></swanseaauthors><date>2012-03-21</date><deptcode>BMS</deptcode><abstract>BACKGROUND: Microbial exposure might play a key role in allergy development, but little is known about the role of Toll-like receptors (TLRs).OBJECTIVE: This study explored the association between neonatal TLR microbial recognition/function, allergy risk (maternal allergy), and prospective allergy development.METHODS: Cord blood mononuclear cells (n = 111) were cultured either alone or with optimal concentrations of TLR ligands: lipoteichoic acid (TLR2), polyinosinicpolycytidylic acid (TLR3), LPS with IFN-gamma (TLR4), flagellin (TLR5), imiquimod R837 (TLR7), or CpG (TLR9). Cytokine responses were assessed in relation to allergy risk (maternal allergy) and allergy outcomes (sensitization, food allergy, and atopic dermatitis) at 12 months of age.RESULTS: Maternal allergy (n = 59) was associated with significantly higher neonatal IL-12 and IFN-gamma responses to TLR2, TLR3, and TLR4 activation, whereas TNF-alpha and IL-6 responses to TLR2, TLR4, and TLR5 activation were significantly higher in newborns who subsequently had allergic disease (n = 32). Notably, consistent with previous reports, newborns who had disease had lower T(H)1 IFN-gamma response to mitogens (PHA).CONCLUSION: Allergic disease was associated with increased (rather than decreased) perinatal TLR responses. Further studies are needed to determine how these responses track in the postnatal period and whether this relative hyperresponsiveness is a product of intrauterine influences, including maternal atopy, functional genetic polymorphisms, or both.</abstract><type>Journal Article</type><journal>Journal of Allergy and Clinical Immunology</journal><volume>122</volume><journalNumber>2</journalNumber><paginationStart>391</paginationStart><paginationEnd>399</paginationEnd><publisher>Elsevier</publisher><issnPrint>00916749</issnPrint><issnElectronic/><keywords>allergy; early life; immunity; toll like receptors</keywords><publishedDay>31</publishedDay><publishedMonth>12</publishedMonth><publishedYear>2008</publishedYear><publishedDate>2008-12-31</publishedDate><doi>10.1016/j.jaci.2008.04.042</doi><url>http://www.sciencedirect.com/science/article/pii/S0091674908007884</url><notes/><college>COLLEGE NANME</college><department>Biomedical Sciences</department><CollegeCode>COLLEGE CODE</CollegeCode><DepartmentCode>BMS</DepartmentCode><institution>Swansea University</institution><apcterm/><lastEdited>2013-11-08T11:15:03.4890358</lastEdited><Created>2012-03-21T16:17:15.0000000</Created><path><level id="1">Faculty of Medicine, Health and Life Sciences</level><level id="2">Swansea University Medical School - Medicine</level></path><authors><author><firstname>SL</firstname><surname>Prescott</surname><order>1</order></author><author><firstname>P</firstname><surname>Noakes</surname><order>2</order></author><author><firstname>al</firstname><surname>BW Chow et</surname><order>3</order></author><author><firstname>L</firstname><surname>Breckler</surname><order>4</order></author><author><firstname>CA</firstname><surname>Thornton</surname><order>5</order></author><author><firstname>EM</firstname><surname>Hollams</surname><order>6</order></author><author><firstname>M</firstname><surname>Ali</surname><order>7</order></author><author><firstname>AH van den</firstname><surname>Biggelaar</surname><order>8</order></author><author><firstname>MK</firstname><surname>Tulic</surname><order>9</order></author><author><firstname>Cathy</firstname><surname>Thornton</surname><orcid>0000-0002-5153-573X</orcid><order>10</order></author></authors><documents/><OutputDurs/></rfc1807> |
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2013-11-08T11:15:03.4890358 v2 9991 2012-03-21 Presymptomatic differences in Toll-like receptor function in infants who have allergy. c71a7a4be7361094d046d312202bce0c 0000-0002-5153-573X Cathy Thornton Cathy Thornton true false 2012-03-21 BMS BACKGROUND: Microbial exposure might play a key role in allergy development, but little is known about the role of Toll-like receptors (TLRs).OBJECTIVE: This study explored the association between neonatal TLR microbial recognition/function, allergy risk (maternal allergy), and prospective allergy development.METHODS: Cord blood mononuclear cells (n = 111) were cultured either alone or with optimal concentrations of TLR ligands: lipoteichoic acid (TLR2), polyinosinicpolycytidylic acid (TLR3), LPS with IFN-gamma (TLR4), flagellin (TLR5), imiquimod R837 (TLR7), or CpG (TLR9). Cytokine responses were assessed in relation to allergy risk (maternal allergy) and allergy outcomes (sensitization, food allergy, and atopic dermatitis) at 12 months of age.RESULTS: Maternal allergy (n = 59) was associated with significantly higher neonatal IL-12 and IFN-gamma responses to TLR2, TLR3, and TLR4 activation, whereas TNF-alpha and IL-6 responses to TLR2, TLR4, and TLR5 activation were significantly higher in newborns who subsequently had allergic disease (n = 32). Notably, consistent with previous reports, newborns who had disease had lower T(H)1 IFN-gamma response to mitogens (PHA).CONCLUSION: Allergic disease was associated with increased (rather than decreased) perinatal TLR responses. Further studies are needed to determine how these responses track in the postnatal period and whether this relative hyperresponsiveness is a product of intrauterine influences, including maternal atopy, functional genetic polymorphisms, or both. Journal Article Journal of Allergy and Clinical Immunology 122 2 391 399 Elsevier 00916749 allergy; early life; immunity; toll like receptors 31 12 2008 2008-12-31 10.1016/j.jaci.2008.04.042 http://www.sciencedirect.com/science/article/pii/S0091674908007884 COLLEGE NANME Biomedical Sciences COLLEGE CODE BMS Swansea University 2013-11-08T11:15:03.4890358 2012-03-21T16:17:15.0000000 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medicine SL Prescott 1 P Noakes 2 al BW Chow et 3 L Breckler 4 CA Thornton 5 EM Hollams 6 M Ali 7 AH van den Biggelaar 8 MK Tulic 9 Cathy Thornton 0000-0002-5153-573X 10 |
title |
Presymptomatic differences in Toll-like receptor function in infants who have allergy. |
spellingShingle |
Presymptomatic differences in Toll-like receptor function in infants who have allergy. Cathy Thornton |
title_short |
Presymptomatic differences in Toll-like receptor function in infants who have allergy. |
title_full |
Presymptomatic differences in Toll-like receptor function in infants who have allergy. |
title_fullStr |
Presymptomatic differences in Toll-like receptor function in infants who have allergy. |
title_full_unstemmed |
Presymptomatic differences in Toll-like receptor function in infants who have allergy. |
title_sort |
Presymptomatic differences in Toll-like receptor function in infants who have allergy. |
author_id_str_mv |
c71a7a4be7361094d046d312202bce0c |
author_id_fullname_str_mv |
c71a7a4be7361094d046d312202bce0c_***_Cathy Thornton |
author |
Cathy Thornton |
author2 |
SL Prescott P Noakes al BW Chow et L Breckler CA Thornton EM Hollams M Ali AH van den Biggelaar MK Tulic Cathy Thornton |
format |
Journal article |
container_title |
Journal of Allergy and Clinical Immunology |
container_volume |
122 |
container_issue |
2 |
container_start_page |
391 |
publishDate |
2008 |
institution |
Swansea University |
issn |
00916749 |
doi_str_mv |
10.1016/j.jaci.2008.04.042 |
publisher |
Elsevier |
college_str |
Faculty of Medicine, Health and Life Sciences |
hierarchytype |
|
hierarchy_top_id |
facultyofmedicinehealthandlifesciences |
hierarchy_top_title |
Faculty of Medicine, Health and Life Sciences |
hierarchy_parent_id |
facultyofmedicinehealthandlifesciences |
hierarchy_parent_title |
Faculty of Medicine, Health and Life Sciences |
department_str |
Swansea University Medical School - Medicine{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Medicine |
url |
http://www.sciencedirect.com/science/article/pii/S0091674908007884 |
document_store_str |
0 |
active_str |
0 |
description |
BACKGROUND: Microbial exposure might play a key role in allergy development, but little is known about the role of Toll-like receptors (TLRs).OBJECTIVE: This study explored the association between neonatal TLR microbial recognition/function, allergy risk (maternal allergy), and prospective allergy development.METHODS: Cord blood mononuclear cells (n = 111) were cultured either alone or with optimal concentrations of TLR ligands: lipoteichoic acid (TLR2), polyinosinicpolycytidylic acid (TLR3), LPS with IFN-gamma (TLR4), flagellin (TLR5), imiquimod R837 (TLR7), or CpG (TLR9). Cytokine responses were assessed in relation to allergy risk (maternal allergy) and allergy outcomes (sensitization, food allergy, and atopic dermatitis) at 12 months of age.RESULTS: Maternal allergy (n = 59) was associated with significantly higher neonatal IL-12 and IFN-gamma responses to TLR2, TLR3, and TLR4 activation, whereas TNF-alpha and IL-6 responses to TLR2, TLR4, and TLR5 activation were significantly higher in newborns who subsequently had allergic disease (n = 32). Notably, consistent with previous reports, newborns who had disease had lower T(H)1 IFN-gamma response to mitogens (PHA).CONCLUSION: Allergic disease was associated with increased (rather than decreased) perinatal TLR responses. Further studies are needed to determine how these responses track in the postnatal period and whether this relative hyperresponsiveness is a product of intrauterine influences, including maternal atopy, functional genetic polymorphisms, or both. |
published_date |
2008-12-31T03:11:28Z |
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1763750013791371264 |
score |
11.021648 |