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Association between the rs4880 superoxide dismutase 2 (C>T) gene variant and coronary heart disease in diabetes mellitus / Sarah, Prior; Danielle, Jones; Danielle, Grant

Diabetes Research and Clinical Practice, Volume: 90, Issue: 2, Pages: 196 - 201

Swansesa University Authors: Sarah, Prior, Danielle, Jones, Danielle, Grant

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DOI (Published version): 10.1016/j.diabres.2010.07.009

Abstract

Mitochondrial superoxide dismutase 2 (SOD2) is an endogenous anti-oxidant enzyme. The rs4880 gene variant results in a C>T substitution, influencing SOD enzymatic activity. This variant has been associated with micro- and macro-vascular complications in diabetes mellitus. Our aim was to exam...

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Published in: Diabetes Research and Clinical Practice
Published: Elsevier 2010
Online Access: http://www.sciencedirect.com/science/article/pii/S0168822710003864
URI: https://cronfa.swan.ac.uk/Record/cronfa10728
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spelling 2014-12-05T14:51:52.7201029 v2 10728 2012-05-09 Association between the rs4880 superoxide dismutase 2 (C>T) gene variant and coronary heart disease in diabetes mellitus cdda101035997acfaa6fdf17097f52b2 0000-0001-8703-8092 Sarah Prior Sarah Prior true false 4d474dbca816c2c209faef443be18a66 Danielle Jones Danielle Jones true false 4d474dbca816c2c209faef443be18a66 Danielle Grant Danielle Grant true false 2012-05-09 PMSC Mitochondrial superoxide dismutase 2 (SOD2) is an endogenous anti-oxidant enzyme. The rs4880 gene variant results in a C&#62;T substitution, influencing SOD enzymatic activity. This variant has been associated with micro- and macro-vascular complications in diabetes mellitus. Our aim was to examine the association between this variant and coronary heart disease (CHD) risk in a cross-sectional sample of subjects with diabetes.776 Caucasian subjects with diabetes were genotyped. CHD risk, oxidised-LDL and plasma total anti-oxidant status (TAOS) were analysed in relation to genotype. In females, the TT genotype was associated with CHD (CC/CT/TT: No CHD vs. CHD: 22.4/56.0/21.6% vs. 12.0/50.0/38.0%, p = 0.03; for CC/CT vs. TT, p = 0.01). The odds ratio for CHD associated with the TT genotype compared to CC/CT was 2.22 [95%CI: 1.17–4.24], p = 0.01. The TT genotype was also associated with significantly lower plasma TAOS. In males, no association was observed between genotype and CHD risk, but CHD was significantly associated with age, lower HDL, higher triglycerides, higher BMI and cigarette smoking.The TT genotype of this variant is associated with increased CHD risk and lower plasma anti-oxidant defences in females with diabetes. This modest genotype-effect is not apparent in males where traditional risk factors may play a greater role. Journal Article Diabetes Research and Clinical Practice 90 2 196 201 Elsevier Superoxide dismutase; Gene variant; Oxidative stress; Diabetes; CHD; rs4880; Mitochondria; Total anti-oxidant status 1 1 2010 2010-01-01 10.1016/j.diabres.2010.07.009 http://www.sciencedirect.com/science/article/pii/S0168822710003864 COLLEGE NANME Medicine COLLEGE CODE PMSC Swansea University 2014-12-05T14:51:52.7201029 2012-05-09T09:52:11.5327947 Swansea University Medical School Medicine Danielle Jones 1 Sarah Prior 0000-0001-8703-8092 2 T Tang 3 Steve Bain 4 Steve Hurel 5 Steve Humphries 6 Jeffrey Stephens 7
title Association between the rs4880 superoxide dismutase 2 (C>T) gene variant and coronary heart disease in diabetes mellitus
spellingShingle Association between the rs4880 superoxide dismutase 2 (C>T) gene variant and coronary heart disease in diabetes mellitus
Sarah, Prior
Danielle, Jones
Danielle, Grant
title_short Association between the rs4880 superoxide dismutase 2 (C>T) gene variant and coronary heart disease in diabetes mellitus
title_full Association between the rs4880 superoxide dismutase 2 (C>T) gene variant and coronary heart disease in diabetes mellitus
title_fullStr Association between the rs4880 superoxide dismutase 2 (C>T) gene variant and coronary heart disease in diabetes mellitus
title_full_unstemmed Association between the rs4880 superoxide dismutase 2 (C>T) gene variant and coronary heart disease in diabetes mellitus
title_sort Association between the rs4880 superoxide dismutase 2 (C>T) gene variant and coronary heart disease in diabetes mellitus
author_id_str_mv cdda101035997acfaa6fdf17097f52b2
4d474dbca816c2c209faef443be18a66
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author_id_fullname_str_mv cdda101035997acfaa6fdf17097f52b2_***_Sarah, Prior
4d474dbca816c2c209faef443be18a66_***_Danielle, Jones
4d474dbca816c2c209faef443be18a66_***_Danielle, Grant
author Sarah, Prior
Danielle, Jones
Danielle, Grant
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publishDate 2010
institution Swansea University
doi_str_mv 10.1016/j.diabres.2010.07.009
publisher Elsevier
college_str Swansea University Medical School
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hierarchy_top_title Swansea University Medical School
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hierarchy_parent_title Swansea University Medical School
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url http://www.sciencedirect.com/science/article/pii/S0168822710003864
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description Mitochondrial superoxide dismutase 2 (SOD2) is an endogenous anti-oxidant enzyme. The rs4880 gene variant results in a C&#62;T substitution, influencing SOD enzymatic activity. This variant has been associated with micro- and macro-vascular complications in diabetes mellitus. Our aim was to examine the association between this variant and coronary heart disease (CHD) risk in a cross-sectional sample of subjects with diabetes.776 Caucasian subjects with diabetes were genotyped. CHD risk, oxidised-LDL and plasma total anti-oxidant status (TAOS) were analysed in relation to genotype. In females, the TT genotype was associated with CHD (CC/CT/TT: No CHD vs. CHD: 22.4/56.0/21.6% vs. 12.0/50.0/38.0%, p = 0.03; for CC/CT vs. TT, p = 0.01). The odds ratio for CHD associated with the TT genotype compared to CC/CT was 2.22 [95%CI: 1.17–4.24], p = 0.01. The TT genotype was also associated with significantly lower plasma TAOS. In males, no association was observed between genotype and CHD risk, but CHD was significantly associated with age, lower HDL, higher triglycerides, higher BMI and cigarette smoking.The TT genotype of this variant is associated with increased CHD risk and lower plasma anti-oxidant defences in females with diabetes. This modest genotype-effect is not apparent in males where traditional risk factors may play a greater role.
published_date 2010-01-01T03:31:08Z
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