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Association of the PGC-1α rs8192678 variant with microalbuminuria in subjects with type 2 diabetes mellitus

Sarah Prior Orcid Logo, A Clark, Danielle Jones, Steve Bain, Steve Hurel, Steve Humphries, Jeffrey Stephens

Disease Markers

Swansea University Authors: Sarah Prior Orcid Logo, Danielle Jones

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DOI (Published version): 10.3233/DMA-2012-0894

Abstract

PPAR-γ co-activator-1α (PGC-1α) is a tissue-specific transcriptional co-activator involved in the regulation of antioxidant enzymes. The A-allele of the rs8192678 PGC-1 α} (G>A) gene variant has previously been associated with nephropathy in Korean and Indian-Asian type 2 diabetes mellitus (T2DM)...

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Published in: Disease Markers
Published: 2012
URI: https://cronfa.swan.ac.uk/Record/cronfa10736
first_indexed 2013-07-23T12:04:10Z
last_indexed 2019-07-02T13:10:30Z
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spelling 2019-07-02T10:02:25.2085700 v2 10736 2012-05-09 Association of the PGC-1α rs8192678 variant with microalbuminuria in subjects with type 2 diabetes mellitus cdda101035997acfaa6fdf17097f52b2 0000-0001-8703-8092 Sarah Prior Sarah Prior true false 4d474dbca816c2c209faef443be18a66 Danielle Jones Danielle Jones true false 2012-05-09 MEDS PPAR-γ co-activator-1α (PGC-1α) is a tissue-specific transcriptional co-activator involved in the regulation of antioxidant enzymes. The A-allele of the rs8192678 PGC-1 α} (G>A) gene variant has previously been associated with nephropathy in Korean and Indian-Asian type 2 diabetes mellitus (T2DM) samples. Our aim was to examine the association between this variant and urine albumin exccretion in European subjects with T2DM. Genotyping was performed on 583 European subjects with T2DM and examined in relation to urinary albumin, plasma oxidized-LDL and small dense-LDL percentage. We observed a significant association between genotype (GG/GA/AA) and urinary albumin (normoalbuminuria v micro/macroalbuminuria: 48.6/39.7/11.7% v 38.2/51.2/10.5%, p=0.02; for GG v GA/AA, p=0.01). The odds ratio for micro/macroalbuminuria in GA and AA subjects relative to GG were 1.70 [1.15–2.50], p=0.008 and 1.20 [0.66–2.16], p=0.56 respectively (for GA/AA v GG: 1.58 [95% CI: 1.09–2.27], p=0.02). There was a significant association between the A allele and a higher percentage of small dense-LDL particles (GG v GA v AA: 70.8 [58.01–81.06] % v 72.8 [56.18–81.19] % v 78.9 [67.16–85.33] %, p=0.03). In European subjects with T2DM the GA relative to the GG genotype is associated with a 70% increase in the risk of micro/microalbuminuria. Furthermore, homozygosity for the A-allele is also associated with a preponderance of small dense-LDL particles. Journal Article Disease Markers PGC-1α, type 2 diabetes mellitus, microalbuminuria, oxidative stress 31 12 2012 2012-12-31 10.3233/DMA-2012-0894 COLLEGE NANME Medical School COLLEGE CODE MEDS Swansea University 2019-07-02T10:02:25.2085700 2012-05-09T13:54:06.6561843 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medicine Sarah Prior 0000-0001-8703-8092 1 A Clark 2 Danielle Jones 3 Steve Bain 4 Steve Hurel 5 Steve Humphries 6 Jeffrey Stephens 7
title Association of the PGC-1α rs8192678 variant with microalbuminuria in subjects with type 2 diabetes mellitus
spellingShingle Association of the PGC-1α rs8192678 variant with microalbuminuria in subjects with type 2 diabetes mellitus
Sarah Prior
Danielle Jones
title_short Association of the PGC-1α rs8192678 variant with microalbuminuria in subjects with type 2 diabetes mellitus
title_full Association of the PGC-1α rs8192678 variant with microalbuminuria in subjects with type 2 diabetes mellitus
title_fullStr Association of the PGC-1α rs8192678 variant with microalbuminuria in subjects with type 2 diabetes mellitus
title_full_unstemmed Association of the PGC-1α rs8192678 variant with microalbuminuria in subjects with type 2 diabetes mellitus
title_sort Association of the PGC-1α rs8192678 variant with microalbuminuria in subjects with type 2 diabetes mellitus
author_id_str_mv cdda101035997acfaa6fdf17097f52b2
4d474dbca816c2c209faef443be18a66
author_id_fullname_str_mv cdda101035997acfaa6fdf17097f52b2_***_Sarah Prior
4d474dbca816c2c209faef443be18a66_***_Danielle Jones
author Sarah Prior
Danielle Jones
author2 Sarah Prior
A Clark
Danielle Jones
Steve Bain
Steve Hurel
Steve Humphries
Jeffrey Stephens
format Journal article
container_title Disease Markers
publishDate 2012
institution Swansea University
doi_str_mv 10.3233/DMA-2012-0894
college_str Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str Swansea University Medical School - Medicine{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Medicine
document_store_str 0
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description PPAR-γ co-activator-1α (PGC-1α) is a tissue-specific transcriptional co-activator involved in the regulation of antioxidant enzymes. The A-allele of the rs8192678 PGC-1 α} (G>A) gene variant has previously been associated with nephropathy in Korean and Indian-Asian type 2 diabetes mellitus (T2DM) samples. Our aim was to examine the association between this variant and urine albumin exccretion in European subjects with T2DM. Genotyping was performed on 583 European subjects with T2DM and examined in relation to urinary albumin, plasma oxidized-LDL and small dense-LDL percentage. We observed a significant association between genotype (GG/GA/AA) and urinary albumin (normoalbuminuria v micro/macroalbuminuria: 48.6/39.7/11.7% v 38.2/51.2/10.5%, p=0.02; for GG v GA/AA, p=0.01). The odds ratio for micro/macroalbuminuria in GA and AA subjects relative to GG were 1.70 [1.15–2.50], p=0.008 and 1.20 [0.66–2.16], p=0.56 respectively (for GA/AA v GG: 1.58 [95% CI: 1.09–2.27], p=0.02). There was a significant association between the A allele and a higher percentage of small dense-LDL particles (GG v GA v AA: 70.8 [58.01–81.06] % v 72.8 [56.18–81.19] % v 78.9 [67.16–85.33] %, p=0.03). In European subjects with T2DM the GA relative to the GG genotype is associated with a 70% increase in the risk of micro/microalbuminuria. Furthermore, homozygosity for the A-allele is also associated with a preponderance of small dense-LDL particles.
published_date 2012-12-31T12:19:03Z
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