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Shotgun cholanomics of ileal fluid / Yingjie Chen, Michael Ogundare, Christopher M Williams, Yuchen Wang, Yuqin Wang, Gavin W Sewell, Philip J Smith, Farooq Z Rahman, Nuala O'Shea, Anthony W Segal, William Griffiths

Biochimie

Swansea University Authors: Yuqin Wang, William Griffiths

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Abstract

In this study we have developed a rapid method for the shotgun analysis of bile acids in intestinal fluid. The method is semi-quantitative, and requires little sample preparation. Bile salts might contribute to the pathogenesis of Crohn’s disease. In a pilot study we demonstrate the method by analys...

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Published in: Biochimie
ISSN: 0300-9084
Published: 2012
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URI: https://cronfa.swan.ac.uk/Record/cronfa12882
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spelling 2011-10-01T00:00:00.0000000 v2 12882 2012-09-26 Shotgun cholanomics of ileal fluid c92729b58622f9fdf6a0e7d8f4ce5081 0000-0002-3063-3066 Yuqin Wang Yuqin Wang true false 3316b1d1b524be1831790933eed1c26e 0000-0002-4129-6616 William Griffiths William Griffiths true false 2012-09-26 BMS In this study we have developed a rapid method for the shotgun analysis of bile acids in intestinal fluid. The method is semi-quantitative, and requires little sample preparation. Bile salts might contribute to the pathogenesis of Crohn’s disease. In a pilot study we demonstrate the method by analysing the bile acid content of ileal fluid from seven Crohn’s disease patients and three healthy controls. The dominant bile acids observed were di and/or trihydroxycholanoates, di- and/or trihydroxycholanoylglycines, di- and/or trihydroxycholanoyltaurines, monosulphated dihydroxycholanoates and monosulphated dihydroxycholanoylglycine. The method can be similarly applied to samples derived from other parts of the intestine. Journal Article Biochimie 0300-9084 Bile acid, Lipidomics, Mass spectrometry, Electrospray ionization, Crohn’s disease. 31 12 2012 2012-12-31 10.1016/j.biochi.2012.09.004 COLLEGE NANME Biomedical Sciences COLLEGE CODE BMS Swansea University 2011-10-01T00:00:00.0000000 2012-09-26T16:47:45.8386057 Swansea University Medical School Medicine Yingjie Chen 1 Michael Ogundare 2 Christopher M Williams 3 Yuchen Wang 4 Yuqin Wang 0000-0002-3063-3066 5 Gavin W Sewell 6 Philip J Smith 7 Farooq Z Rahman 8 Nuala O'Shea 9 Anthony W Segal 10 William Griffiths 0000-0002-4129-6616 11
title Shotgun cholanomics of ileal fluid
spellingShingle Shotgun cholanomics of ileal fluid
Yuqin, Wang
William, Griffiths
title_short Shotgun cholanomics of ileal fluid
title_full Shotgun cholanomics of ileal fluid
title_fullStr Shotgun cholanomics of ileal fluid
title_full_unstemmed Shotgun cholanomics of ileal fluid
title_sort Shotgun cholanomics of ileal fluid
author_id_str_mv c92729b58622f9fdf6a0e7d8f4ce5081
3316b1d1b524be1831790933eed1c26e
author_id_fullname_str_mv c92729b58622f9fdf6a0e7d8f4ce5081_***_Yuqin, Wang
3316b1d1b524be1831790933eed1c26e_***_William, Griffiths
author Yuqin, Wang
William, Griffiths
author2 Yingjie Chen
Michael Ogundare
Christopher M Williams
Yuchen Wang
Yuqin Wang
Gavin W Sewell
Philip J Smith
Farooq Z Rahman
Nuala O'Shea
Anthony W Segal
William Griffiths
format Journal article
container_title Biochimie
publishDate 2012
institution Swansea University
issn 0300-9084
doi_str_mv 10.1016/j.biochi.2012.09.004
college_str Swansea University Medical School
hierarchytype
hierarchy_top_id swanseauniversitymedicalschool
hierarchy_top_title Swansea University Medical School
hierarchy_parent_id swanseauniversitymedicalschool
hierarchy_parent_title Swansea University Medical School
department_str Medicine{{{_:::_}}}Swansea University Medical School{{{_:::_}}}Medicine
document_store_str 0
active_str 0
description In this study we have developed a rapid method for the shotgun analysis of bile acids in intestinal fluid. The method is semi-quantitative, and requires little sample preparation. Bile salts might contribute to the pathogenesis of Crohn’s disease. In a pilot study we demonstrate the method by analysing the bile acid content of ileal fluid from seven Crohn’s disease patients and three healthy controls. The dominant bile acids observed were di and/or trihydroxycholanoates, di- and/or trihydroxycholanoylglycines, di- and/or trihydroxycholanoyltaurines, monosulphated dihydroxycholanoates and monosulphated dihydroxycholanoylglycine. The method can be similarly applied to samples derived from other parts of the intestine.
published_date 2012-12-31T03:27:52Z
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score 10.853087