Shotgun cholanomics of ileal fluid

Chen, Yingjie; Ogundare, Michael; Williams, Christopher M; Wang, Yuchen; Wang, Yuqin; Sewell, Gavin W; Smith, Philip J; Rahman, Farooq Z; O'Shea, Nuala; Segal, Anthony W; Griffiths, William

doi:10.1016/j.biochi.2012.09.004

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Shotgun cholanomics of ileal fluid

Yingjie Chen, Michael Ogundare, Christopher M Williams, Yuchen Wang, Yuqin Wang

, Gavin W Sewell, Philip J Smith, Farooq Z Rahman, Nuala O'Shea, Anthony W Segal, William Griffiths

Biochimie

Swansea University Authors: Yuqin Wang , William Griffiths

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DOI (Published version): 10.1016/j.biochi.2012.09.004

Abstract

In this study we have developed a rapid method for the shotgun analysis of bile acids in intestinal fluid. The method is semi-quantitative, and requires little sample preparation. Bile salts might contribute to the pathogenesis of Crohn’s disease. In a pilot study we demonstrate the method by analys...

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Published in:	Biochimie
ISSN:	0300-9084
Published:	2012
Online Access:	Check full text
URI:	https://cronfa.swan.ac.uk/Record/cronfa12882
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first_indexed	2013-07-23T12:08:58Z
last_indexed	2018-02-09T04:43:16Z
id	cronfa12882
recordtype	SURis
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spelling	2011-10-01T00:00:00.0000000 v2 12882 2012-09-26 Shotgun cholanomics of ileal fluid c92729b58622f9fdf6a0e7d8f4ce5081 0000-0002-3063-3066 Yuqin Wang Yuqin Wang true false 3316b1d1b524be1831790933eed1c26e 0000-0002-4129-6616 William Griffiths William Griffiths true false 2012-09-26 BMS In this study we have developed a rapid method for the shotgun analysis of bile acids in intestinal fluid. The method is semi-quantitative, and requires little sample preparation. Bile salts might contribute to the pathogenesis of Crohn’s disease. In a pilot study we demonstrate the method by analysing the bile acid content of ileal fluid from seven Crohn’s disease patients and three healthy controls. The dominant bile acids observed were di and/or trihydroxycholanoates, di- and/or trihydroxycholanoylglycines, di- and/or trihydroxycholanoyltaurines, monosulphated dihydroxycholanoates and monosulphated dihydroxycholanoylglycine. The method can be similarly applied to samples derived from other parts of the intestine. Journal Article Biochimie 0300-9084 Bile acid, Lipidomics, Mass spectrometry, Electrospray ionization, Crohn’s disease. 31 12 2012 2012-12-31 10.1016/j.biochi.2012.09.004 COLLEGE NANME Biomedical Sciences COLLEGE CODE BMS Swansea University 2011-10-01T00:00:00.0000000 2012-09-26T16:47:45.8386057 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medicine Yingjie Chen 1 Michael Ogundare 2 Christopher M Williams 3 Yuchen Wang 4 Yuqin Wang 0000-0002-3063-3066 5 Gavin W Sewell 6 Philip J Smith 7 Farooq Z Rahman 8 Nuala O'Shea 9 Anthony W Segal 10 William Griffiths 0000-0002-4129-6616 11
title	Shotgun cholanomics of ileal fluid
spellingShingle	Shotgun cholanomics of ileal fluid Yuqin Wang William Griffiths
title_short	Shotgun cholanomics of ileal fluid
title_full	Shotgun cholanomics of ileal fluid
title_fullStr	Shotgun cholanomics of ileal fluid
title_full_unstemmed	Shotgun cholanomics of ileal fluid
title_sort	Shotgun cholanomics of ileal fluid
author_id_str_mv	c92729b58622f9fdf6a0e7d8f4ce5081 3316b1d1b524be1831790933eed1c26e
author_id_fullname_str_mv	c92729b58622f9fdf6a0e7d8f4ce5081_*_Yuqin Wang 3316b1d1b524be1831790933eed1c26e_*_William Griffiths
author	Yuqin Wang William Griffiths
author2	Yingjie Chen Michael Ogundare Christopher M Williams Yuchen Wang Yuqin Wang Gavin W Sewell Philip J Smith Farooq Z Rahman Nuala O'Shea Anthony W Segal William Griffiths
format	Journal article
container_title	Biochimie
publishDate	2012
institution	Swansea University
issn	0300-9084
doi_str_mv	10.1016/j.biochi.2012.09.004
college_str	Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id	facultyofmedicinehealthandlifesciences
hierarchy_top_title	Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id	facultyofmedicinehealthandlifesciences
hierarchy_parent_title	Faculty of Medicine, Health and Life Sciences
department_str	Swansea University Medical School - Medicine{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Medicine
document_store_str	0
active_str	0
description	In this study we have developed a rapid method for the shotgun analysis of bile acids in intestinal fluid. The method is semi-quantitative, and requires little sample preparation. Bile salts might contribute to the pathogenesis of Crohn’s disease. In a pilot study we demonstrate the method by analysing the bile acid content of ileal fluid from seven Crohn’s disease patients and three healthy controls. The dominant bile acids observed were di and/or trihydroxycholanoates, di- and/or trihydroxycholanoylglycines, di- and/or trihydroxycholanoyltaurines, monosulphated dihydroxycholanoates and monosulphated dihydroxycholanoylglycine. The method can be similarly applied to samples derived from other parts of the intestine.
published_date	2012-12-31T03:14:46Z
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score	11.021648

Shotgun cholanomics of ileal fluid

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