Journal article 1381 views
Shotgun cholanomics of ileal fluid
Yingjie Chen,
Michael Ogundare,
Christopher M Williams,
Yuchen Wang,
Yuqin Wang 
,
Gavin W Sewell,
Philip J Smith,
Farooq Z Rahman,
Nuala O'Shea,
Anthony W Segal,
William Griffiths
,
Gavin W Sewell,
Philip J Smith,
Farooq Z Rahman,
Nuala O'Shea,
Anthony W Segal,
William Griffiths
Biochimie
Swansea University Authors:
Yuqin Wang , William Griffiths
Full text not available from this repository: check for access using links below.
DOI (Published version): 10.1016/j.biochi.2012.09.004
Abstract
In this study we have developed a rapid method for the shotgun analysis of bile acids in intestinal fluid. The method is semi-quantitative, and requires little sample preparation. Bile salts might contribute to the pathogenesis of Crohn’s disease. In a pilot study we demonstrate the method by analys...
| Published in: | Biochimie |
|---|---|
| ISSN: | 0300-9084 |
| Published: |
2012
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| Online Access: |
Check full text
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| URI: | https://cronfa.swan.ac.uk/Record/cronfa12882 |
| first_indexed |
2013-07-23T12:08:58Z |
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| last_indexed |
2018-02-09T04:43:16Z |
| id |
cronfa12882 |
| recordtype |
SURis |
| fullrecord |
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| spelling |
2011-10-01T00:00:00.0000000 v2 12882 2012-09-26 Shotgun cholanomics of ileal fluid c92729b58622f9fdf6a0e7d8f4ce5081 0000-0002-3063-3066 Yuqin Wang Yuqin Wang true false 3316b1d1b524be1831790933eed1c26e 0000-0002-4129-6616 William Griffiths William Griffiths true false 2012-09-26 MEDS In this study we have developed a rapid method for the shotgun analysis of bile acids in intestinal fluid. The method is semi-quantitative, and requires little sample preparation. Bile salts might contribute to the pathogenesis of Crohn’s disease. In a pilot study we demonstrate the method by analysing the bile acid content of ileal fluid from seven Crohn’s disease patients and three healthy controls. The dominant bile acids observed were di and/or trihydroxycholanoates, di- and/or trihydroxycholanoylglycines, di- and/or trihydroxycholanoyltaurines, monosulphated dihydroxycholanoates and monosulphated dihydroxycholanoylglycine. The method can be similarly applied to samples derived from other parts of the intestine. Journal Article Biochimie 0300-9084 Bile acid, Lipidomics, Mass spectrometry, Electrospray ionization, Crohn’s disease. 31 12 2012 2012-12-31 10.1016/j.biochi.2012.09.004 COLLEGE NANME Medical School COLLEGE CODE MEDS Swansea University 2011-10-01T00:00:00.0000000 2012-09-26T16:47:45.8386057 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medicine Yingjie Chen 1 Michael Ogundare 2 Christopher M Williams 3 Yuchen Wang 4 Yuqin Wang 0000-0002-3063-3066 5 Gavin W Sewell 6 Philip J Smith 7 Farooq Z Rahman 8 Nuala O'Shea 9 Anthony W Segal 10 William Griffiths 0000-0002-4129-6616 11 |
| title |
Shotgun cholanomics of ileal fluid |
| spellingShingle |
Shotgun cholanomics of ileal fluid Yuqin Wang William Griffiths |
| title_short |
Shotgun cholanomics of ileal fluid |
| title_full |
Shotgun cholanomics of ileal fluid |
| title_fullStr |
Shotgun cholanomics of ileal fluid |
| title_full_unstemmed |
Shotgun cholanomics of ileal fluid |
| title_sort |
Shotgun cholanomics of ileal fluid |
| author_id_str_mv |
c92729b58622f9fdf6a0e7d8f4ce5081 3316b1d1b524be1831790933eed1c26e |
| author_id_fullname_str_mv |
c92729b58622f9fdf6a0e7d8f4ce5081_***_Yuqin Wang 3316b1d1b524be1831790933eed1c26e_***_William Griffiths |
| author |
Yuqin Wang William Griffiths |
| author2 |
Yingjie Chen Michael Ogundare Christopher M Williams Yuchen Wang Yuqin Wang Gavin W Sewell Philip J Smith Farooq Z Rahman Nuala O'Shea Anthony W Segal William Griffiths |
| format |
Journal article |
| container_title |
Biochimie |
| publishDate |
2012 |
| institution |
Swansea University |
| issn |
0300-9084 |
| doi_str_mv |
10.1016/j.biochi.2012.09.004 |
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Faculty of Medicine, Health and Life Sciences |
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|
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facultyofmedicinehealthandlifesciences |
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Faculty of Medicine, Health and Life Sciences |
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facultyofmedicinehealthandlifesciences |
| hierarchy_parent_title |
Faculty of Medicine, Health and Life Sciences |
| department_str |
Swansea University Medical School - Medicine{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Medicine |
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0 |
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| description |
In this study we have developed a rapid method for the shotgun analysis of bile acids in intestinal fluid. The method is semi-quantitative, and requires little sample preparation. Bile salts might contribute to the pathogenesis of Crohn’s disease. In a pilot study we demonstrate the method by analysing the bile acid content of ileal fluid from seven Crohn’s disease patients and three healthy controls. The dominant bile acids observed were di and/or trihydroxycholanoates, di- and/or trihydroxycholanoylglycines, di- and/or trihydroxycholanoyltaurines, monosulphated dihydroxycholanoates and monosulphated dihydroxycholanoylglycine. The method can be similarly applied to samples derived from other parts of the intestine. |
| published_date |
2012-12-31T04:20:37Z |
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1850821823266029568 |
| score |
11.08895 |