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Two clinical isolates of Candida glabrata exhibiting reduced sensitivity to amphotericin B both harbor mutations in ERG2. / CM Hull; O Bader; JE Parker; M Weig; U Gross; AG Warrilow; DE Kelly; Steven Kelly

Antimicrob Agents Chemother. 2012 Oct 1. [Epub ahead of print]

Swansea University Author: Steven, Kelly

Abstract

Two novel isolates of Candida glabrata exhibiting reduced sensitivity to amphotericin B (MIC 8 μg ml(-1)) were found to be erg2 mutants wherein Δ(8)-sterol intermediates comprised > 90% of the total cellular sterol fraction. Both harbored an alteration at Thr(121) in Erg2; the corresponding resid...

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Published in: Antimicrob Agents Chemother. 2012 Oct 1. [Epub ahead of print]
Published: 2012
URI: https://cronfa.swan.ac.uk/Record/cronfa13028
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Abstract: Two novel isolates of Candida glabrata exhibiting reduced sensitivity to amphotericin B (MIC 8 μg ml(-1)) were found to be erg2 mutants wherein Δ(8)-sterol intermediates comprised > 90% of the total cellular sterol fraction. Both harbored an alteration at Thr(121) in Erg2; the corresponding residue (Thr(119)) in Saccharomyces cerevisiae is essential for sterol Δ8-Δ7 isomerization. This constitutes the first report of C. glabrata harboring mutations in ERG2 and exhibiting reduced sensitivity to amphotericin B.
College: Swansea University Medical School