No Cover Image

Journal article 632 views

Two Clinical Isolates of Candida glabrata Exhibiting Reduced Sensitivity to Amphotericin B Both Harbor Mutations inERG2 / Claire Hull, Oliver Bader, Josie Parker, Michael Weig, Uwe Gross, Andrew Warrilow, Diane Kelly, Steven Kelly

Antimicrobial Agents and Chemotherapy, Volume: 56, Issue: 12, Pages: 6417 - 6421

Swansea University Authors: Claire Hull, Josie Parker, Andrew Warrilow, Diane Kelly, Steven Kelly

Full text not available from this repository: check for access using links below.

Check full text

DOI (Published version): 10.1128/aac.01145-12

Abstract

Two novel isolates of Candida glabrata exhibiting reduced sensitivity to amphotericin B (MIC 8 μg ml(-1)) were found to be erg2 mutants wherein Δ(8)-sterol intermediates comprised > 90% of the total cellular sterol fraction. Both harbored an alteration at Thr(121) in Erg2; the corresponding resid...

Full description

Published in: Antimicrobial Agents and Chemotherapy
ISSN: 0066-4804 1098-6596
Published: American Society for Microbiology 2012
Online Access: Check full text

URI: https://cronfa.swan.ac.uk/Record/cronfa13028
Tags: Add Tag
No Tags, Be the first to tag this record!
Abstract: Two novel isolates of Candida glabrata exhibiting reduced sensitivity to amphotericin B (MIC 8 μg ml(-1)) were found to be erg2 mutants wherein Δ(8)-sterol intermediates comprised > 90% of the total cellular sterol fraction. Both harbored an alteration at Thr(121) in Erg2; the corresponding residue (Thr(119)) in Saccharomyces cerevisiae is essential for sterol Δ8-Δ7 isomerization. This constitutes the first report of C. glabrata harboring mutations in ERG2 and exhibiting reduced sensitivity to amphotericin B.
College: Swansea University Medical School
Issue: 12
Start Page: 6417
End Page: 6421