Journal article 1408 views
Two Clinical Isolates of Candida glabrata Exhibiting Reduced Sensitivity to Amphotericin B Both Harbor Mutations inERG2
Antimicrobial Agents and Chemotherapy, Volume: 56, Issue: 12, Pages: 6417 - 6421
Swansea University Authors: Claire Hull, Josie Parker, Andrew Warrilow, Diane Kelly, Steven Kelly
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DOI (Published version): 10.1128/aac.01145-12
Abstract
Two novel isolates of Candida glabrata exhibiting reduced sensitivity to amphotericin B (MIC 8 μg ml(-1)) were found to be erg2 mutants wherein Δ(8)-sterol intermediates comprised > 90% of the total cellular sterol fraction. Both harbored an alteration at Thr(121) in Erg2; the corresponding resid...
Published in: | Antimicrobial Agents and Chemotherapy |
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ISSN: | 0066-4804 1098-6596 |
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American Society for Microbiology
2012
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URI: | https://cronfa.swan.ac.uk/Record/cronfa13028 |
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2021-10-29T09:53:11.3373618 v2 13028 2012-10-10 Two Clinical Isolates of Candida glabrata Exhibiting Reduced Sensitivity to Amphotericin B Both Harbor Mutations inERG2 6c495cb489b67bc9bb3f746975c4ff19 Claire Hull Claire Hull true false e563ed4e1c7db8d1e131fb78a5f8d0d5 Josie Parker Josie Parker true false f066e233e8d0136c9f547b86fa43747f Andrew Warrilow Andrew Warrilow true false 5ccf81e5d5beedf32ef8d7c3d7ac6c8c Diane Kelly Diane Kelly true false b17cebaf09b4d737b9378a3581e3de93 0000-0001-7991-5040 Steven Kelly Steven Kelly true false 2012-10-10 PMSC Two novel isolates of Candida glabrata exhibiting reduced sensitivity to amphotericin B (MIC 8 μg ml(-1)) were found to be erg2 mutants wherein Δ(8)-sterol intermediates comprised > 90% of the total cellular sterol fraction. Both harbored an alteration at Thr(121) in Erg2; the corresponding residue (Thr(119)) in Saccharomyces cerevisiae is essential for sterol Δ8-Δ7 isomerization. This constitutes the first report of C. glabrata harboring mutations in ERG2 and exhibiting reduced sensitivity to amphotericin B. Journal Article Antimicrobial Agents and Chemotherapy 56 12 6417 6421 American Society for Microbiology 0066-4804 1098-6596 1 12 2012 2012-12-01 10.1128/aac.01145-12 http://dx.doi.org/10.1128/aac.01145-12 COLLEGE NANME Medicine COLLEGE CODE PMSC Swansea University 2021-10-29T09:53:11.3373618 2012-10-10T10:34:54.4642667 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medicine Claire Hull 1 Oliver Bader 2 Josie Parker 3 Michael Weig 4 Uwe Gross 5 Andrew Warrilow 6 Diane Kelly 7 Steven Kelly 0000-0001-7991-5040 8 |
title |
Two Clinical Isolates of Candida glabrata Exhibiting Reduced Sensitivity to Amphotericin B Both Harbor Mutations inERG2 |
spellingShingle |
Two Clinical Isolates of Candida glabrata Exhibiting Reduced Sensitivity to Amphotericin B Both Harbor Mutations inERG2 Claire Hull Josie Parker Andrew Warrilow Diane Kelly Steven Kelly |
title_short |
Two Clinical Isolates of Candida glabrata Exhibiting Reduced Sensitivity to Amphotericin B Both Harbor Mutations inERG2 |
title_full |
Two Clinical Isolates of Candida glabrata Exhibiting Reduced Sensitivity to Amphotericin B Both Harbor Mutations inERG2 |
title_fullStr |
Two Clinical Isolates of Candida glabrata Exhibiting Reduced Sensitivity to Amphotericin B Both Harbor Mutations inERG2 |
title_full_unstemmed |
Two Clinical Isolates of Candida glabrata Exhibiting Reduced Sensitivity to Amphotericin B Both Harbor Mutations inERG2 |
title_sort |
Two Clinical Isolates of Candida glabrata Exhibiting Reduced Sensitivity to Amphotericin B Both Harbor Mutations inERG2 |
author_id_str_mv |
6c495cb489b67bc9bb3f746975c4ff19 e563ed4e1c7db8d1e131fb78a5f8d0d5 f066e233e8d0136c9f547b86fa43747f 5ccf81e5d5beedf32ef8d7c3d7ac6c8c b17cebaf09b4d737b9378a3581e3de93 |
author_id_fullname_str_mv |
6c495cb489b67bc9bb3f746975c4ff19_***_Claire Hull e563ed4e1c7db8d1e131fb78a5f8d0d5_***_Josie Parker f066e233e8d0136c9f547b86fa43747f_***_Andrew Warrilow 5ccf81e5d5beedf32ef8d7c3d7ac6c8c_***_Diane Kelly b17cebaf09b4d737b9378a3581e3de93_***_Steven Kelly |
author |
Claire Hull Josie Parker Andrew Warrilow Diane Kelly Steven Kelly |
author2 |
Claire Hull Oliver Bader Josie Parker Michael Weig Uwe Gross Andrew Warrilow Diane Kelly Steven Kelly |
format |
Journal article |
container_title |
Antimicrobial Agents and Chemotherapy |
container_volume |
56 |
container_issue |
12 |
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6417 |
publishDate |
2012 |
institution |
Swansea University |
issn |
0066-4804 1098-6596 |
doi_str_mv |
10.1128/aac.01145-12 |
publisher |
American Society for Microbiology |
college_str |
Faculty of Medicine, Health and Life Sciences |
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|
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facultyofmedicinehealthandlifesciences |
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Faculty of Medicine, Health and Life Sciences |
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Faculty of Medicine, Health and Life Sciences |
department_str |
Swansea University Medical School - Medicine{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Medicine |
url |
http://dx.doi.org/10.1128/aac.01145-12 |
document_store_str |
0 |
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description |
Two novel isolates of Candida glabrata exhibiting reduced sensitivity to amphotericin B (MIC 8 μg ml(-1)) were found to be erg2 mutants wherein Δ(8)-sterol intermediates comprised > 90% of the total cellular sterol fraction. Both harbored an alteration at Thr(121) in Erg2; the corresponding residue (Thr(119)) in Saccharomyces cerevisiae is essential for sterol Δ8-Δ7 isomerization. This constitutes the first report of C. glabrata harboring mutations in ERG2 and exhibiting reduced sensitivity to amphotericin B. |
published_date |
2012-12-01T03:14:55Z |
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1763750231127621632 |
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11.028774 |