Journal article 1469 views
Two Clinical Isolates of Candida glabrata Exhibiting Reduced Sensitivity to Amphotericin B Both Harbor Mutations inERG2
Antimicrobial Agents and Chemotherapy, Volume: 56, Issue: 12, Pages: 6417 - 6421
Swansea University Authors: Claire Hull, Josie Parker, Andrew Warrilow, Diane Kelly, Steven Kelly
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DOI (Published version): 10.1128/aac.01145-12
Abstract
Two novel isolates of Candida glabrata exhibiting reduced sensitivity to amphotericin B (MIC 8 μg ml(-1)) were found to be erg2 mutants wherein Δ(8)-sterol intermediates comprised > 90% of the total cellular sterol fraction. Both harbored an alteration at Thr(121) in Erg2; the corresponding resid...
| Published in: | Antimicrobial Agents and Chemotherapy |
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| ISSN: | 0066-4804 1098-6596 |
| Published: |
American Society for Microbiology
2012
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| Online Access: |
Check full text
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| URI: | https://cronfa.swan.ac.uk/Record/cronfa13028 |
| Abstract: |
Two novel isolates of Candida glabrata exhibiting reduced sensitivity to amphotericin B (MIC 8 μg ml(-1)) were found to be erg2 mutants wherein Δ(8)-sterol intermediates comprised > 90% of the total cellular sterol fraction. Both harbored an alteration at Thr(121) in Erg2; the corresponding residue (Thr(119)) in Saccharomyces cerevisiae is essential for sterol Δ8-Δ7 isomerization. This constitutes the first report of C. glabrata harboring mutations in ERG2 and exhibiting reduced sensitivity to amphotericin B. |
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| College: |
Faculty of Medicine, Health and Life Sciences |
| Issue: |
12 |
| Start Page: |
6417 |
| End Page: |
6421 |