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A comprehensive machine-readable view of the mammalian cholesterol biosynthesis pathway / William, Griffiths

Biochemical Pharmacology

Swansea University Author: William, Griffiths

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Abstract

Cholesterol biosynthesis serves as a central metabolic hub for numerous biological processes in health and disease. A detailed, integrative single-view description of how the cholesterol pathway is structured and how it interacts with other pathway systems is lacking in the existing literature. Here...

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Published in: Biochemical Pharmacology
ISSN: 0006-2952
Published: 2013
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URI: https://cronfa.swan.ac.uk/Record/cronfa14862
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Abstract: Cholesterol biosynthesis serves as a central metabolic hub for numerous biological processes in health and disease. A detailed, integrative single-view description of how the cholesterol pathway is structured and how it interacts with other pathway systems is lacking in the existing literature. Here we provide a systematic review of the existing literature and present a detailed pathway diagram that describes the cholesterol biosynthesis pathway (the mevalonate, the Kandutch-Russell and the Bloch pathway) and shunt pathway that leads to 24(S),25-epoxycholesterol synthesis. The diagram has been produced using the Systems Biology Graphical Notation (SBGN) and is available in the SBGN-ML format, a human readable and machine semantically parsable open community file format.
College: Swansea University Medical School