Journal article 1172 views
A comprehensive machine-readable view of the mammalian cholesterol biosynthesis pathway
Biochemical Pharmacology
Swansea University Author:
William Griffiths
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DOI (Published version): 10.1016/j.bcp.2013.03.021
Abstract
Cholesterol biosynthesis serves as a central metabolic hub for numerous biological processes in health and disease. A detailed, integrative single-view description of how the cholesterol pathway is structured and how it interacts with other pathway systems is lacking in the existing literature. Here...
Published in: | Biochemical Pharmacology |
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ISSN: | 0006-2952 |
Published: |
2013
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URI: | https://cronfa.swan.ac.uk/Record/cronfa14862 |
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2013-05-22T10:29:00.5760993 v2 14862 2013-05-22 A comprehensive machine-readable view of the mammalian cholesterol biosynthesis pathway 3316b1d1b524be1831790933eed1c26e 0000-0002-4129-6616 William Griffiths William Griffiths true false 2013-05-22 BMS Cholesterol biosynthesis serves as a central metabolic hub for numerous biological processes in health and disease. A detailed, integrative single-view description of how the cholesterol pathway is structured and how it interacts with other pathway systems is lacking in the existing literature. Here we provide a systematic review of the existing literature and present a detailed pathway diagram that describes the cholesterol biosynthesis pathway (the mevalonate, the Kandutch-Russell and the Bloch pathway) and shunt pathway that leads to 24(S),25-epoxycholesterol synthesis. The diagram has been produced using the Systems Biology Graphical Notation (SBGN) and is available in the SBGN-ML format, a human readable and machine semantically parsable open community file format. Journal Article Biochemical Pharmacology 0006-2952 31 12 2013 2013-12-31 10.1016/j.bcp.2013.03.021 COLLEGE NANME Biomedical Sciences COLLEGE CODE BMS Swansea University 2013-05-22T10:29:00.5760993 2013-05-22T10:29:00.5790291 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medicine Alexander Mazein 1 Steven Watterson 2 Wei-Yuan Hsieh 3 William Griffiths 0000-0002-4129-6616 4 Peter Ghazal 5 |
title |
A comprehensive machine-readable view of the mammalian cholesterol biosynthesis pathway |
spellingShingle |
A comprehensive machine-readable view of the mammalian cholesterol biosynthesis pathway William Griffiths |
title_short |
A comprehensive machine-readable view of the mammalian cholesterol biosynthesis pathway |
title_full |
A comprehensive machine-readable view of the mammalian cholesterol biosynthesis pathway |
title_fullStr |
A comprehensive machine-readable view of the mammalian cholesterol biosynthesis pathway |
title_full_unstemmed |
A comprehensive machine-readable view of the mammalian cholesterol biosynthesis pathway |
title_sort |
A comprehensive machine-readable view of the mammalian cholesterol biosynthesis pathway |
author_id_str_mv |
3316b1d1b524be1831790933eed1c26e |
author_id_fullname_str_mv |
3316b1d1b524be1831790933eed1c26e_***_William Griffiths |
author |
William Griffiths |
author2 |
Alexander Mazein Steven Watterson Wei-Yuan Hsieh William Griffiths Peter Ghazal |
format |
Journal article |
container_title |
Biochemical Pharmacology |
publishDate |
2013 |
institution |
Swansea University |
issn |
0006-2952 |
doi_str_mv |
10.1016/j.bcp.2013.03.021 |
college_str |
Faculty of Medicine, Health and Life Sciences |
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|
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facultyofmedicinehealthandlifesciences |
hierarchy_top_title |
Faculty of Medicine, Health and Life Sciences |
hierarchy_parent_id |
facultyofmedicinehealthandlifesciences |
hierarchy_parent_title |
Faculty of Medicine, Health and Life Sciences |
department_str |
Swansea University Medical School - Medicine{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Medicine |
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active_str |
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description |
Cholesterol biosynthesis serves as a central metabolic hub for numerous biological processes in health and disease. A detailed, integrative single-view description of how the cholesterol pathway is structured and how it interacts with other pathway systems is lacking in the existing literature. Here we provide a systematic review of the existing literature and present a detailed pathway diagram that describes the cholesterol biosynthesis pathway (the mevalonate, the Kandutch-Russell and the Bloch pathway) and shunt pathway that leads to 24(S),25-epoxycholesterol synthesis. The diagram has been produced using the Systems Biology Graphical Notation (SBGN) and is available in the SBGN-ML format, a human readable and machine semantically parsable open community file format. |
published_date |
2013-12-31T03:17:00Z |
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1763750361696305152 |
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11.021648 |