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Clotrimazole as a Potent Agent for Treating the Oomycete Fish Pathogen Saprolegnia parasitica through Inhibition of Sterol 14 -Demethylase (CYP51) / A. G. S. Warrilow; C. M. Hull; N. J. Rolley; J. E. Parker; W. D. Nes; S. N. Smith; D. E. Kelly; S. L. Kelly; Steven Kelly; Diane Kelly; Josie Parker; Claire Hull; Andrew Warrilow

Applied and Environmental Microbiology, Volume: 80, Issue: 19, Pages: 6154 - 6166

Swansea University Authors: Steven, Kelly, Diane, Kelly, Josie, Parker, Claire, Hull, Andrew, Warrilow

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DOI (Published version): 10.1128/AEM.01195-14

Abstract

We have shown that Clotrimazole is an inhibitor of CYP51 in the fish pathogen Saprolegnia parasitica. Our study suggests that it may be used as a preventive treatment against the oomycete infection.

Published in: Applied and Environmental Microbiology
Published: 2014
URI: https://cronfa.swan.ac.uk/Record/cronfa18616
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Abstract: We have shown that Clotrimazole is an inhibitor of CYP51 in the fish pathogen Saprolegnia parasitica. Our study suggests that it may be used as a preventive treatment against the oomycete infection.
Keywords: CYP51; Saprolegnia parasitica
College: Swansea University Medical School
Issue: 19
Start Page: 6154
End Page: 6166