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Clotrimazole as a Potent Agent for Treating the Oomycete Fish Pathogen Saprolegnia parasitica through Inhibition of Sterol 14 -Demethylase (CYP51)

Andrew Warrilow, Claire Hull, N. J. Rolley, Josie Parker Orcid Logo, W. D. Nes, S. N. Smith, Diane Kelly, Steven Kelly Orcid Logo

Applied and Environmental Microbiology, Volume: 80, Issue: 19, Pages: 6154 - 6166

Swansea University Authors: Andrew Warrilow, Claire Hull, Josie Parker Orcid Logo, Diane Kelly, Steven Kelly Orcid Logo

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DOI (Published version): 10.1128/AEM.01195-14

Abstract

We have shown that Clotrimazole is an inhibitor of CYP51 in the fish pathogen Saprolegnia parasitica. Our study suggests that it may be used as a preventive treatment against the oomycete infection.

Published in: Applied and Environmental Microbiology
Published: 2014
URI: https://cronfa.swan.ac.uk/Record/cronfa18616
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Abstract: We have shown that Clotrimazole is an inhibitor of CYP51 in the fish pathogen Saprolegnia parasitica. Our study suggests that it may be used as a preventive treatment against the oomycete infection.
Keywords: CYP51; Saprolegnia parasitica
College: Swansea University Medical School
Issue: 19
Start Page: 6154
End Page: 6166