No Cover Image

Journal article 634 views

Clotrimazole as a Potent Agent for Treating the Oomycete Fish Pathogen Saprolegnia parasitica through Inhibition of Sterol 14 -Demethylase (CYP51) / A. G. S. Warrilow; C. M. Hull; N. J. Rolley; J. E. Parker; W. D. Nes; S. N. Smith; D. E. Kelly; S. L. Kelly; Steven Kelly; Diane Kelly; Josie Parker; Claire Hull; Andrew Warrilow

Applied and Environmental Microbiology, Volume: 80, Issue: 19, Pages: 6154 - 6166

Swansea University Authors: Steven, Kelly, Diane, Kelly, Josie, Parker, Claire, Hull, Andrew, Warrilow

Full text not available from this repository: check for access using links below.

DOI (Published version): 10.1128/AEM.01195-14

Abstract

We have shown that Clotrimazole is an inhibitor of CYP51 in the fish pathogen Saprolegnia parasitica. Our study suggests that it may be used as a preventive treatment against the oomycete infection.

Published in: Applied and Environmental Microbiology
Published: 2014
URI: https://cronfa.swan.ac.uk/Record/cronfa18616
Tags: Add Tag
No Tags, Be the first to tag this record!
first_indexed 2014-10-07T01:58:15Z
last_indexed 2018-02-09T04:53:24Z
id cronfa18616
recordtype SURis
fullrecord <?xml version="1.0"?><rfc1807><datestamp>2015-03-12T16:16:27.0477393</datestamp><bib-version>v2</bib-version><id>18616</id><entry>2014-10-06</entry><title>Clotrimazole as a Potent Agent for Treating the Oomycete Fish Pathogen Saprolegnia parasitica through Inhibition of Sterol 14&#xA0;-Demethylase (CYP51)</title><swanseaauthors><author><sid>b17cebaf09b4d737b9378a3581e3de93</sid><ORCID>0000-0001-7991-5040</ORCID><firstname>Steven</firstname><surname>Kelly</surname><name>Steven Kelly</name><active>true</active><ethesisStudent>false</ethesisStudent></author><author><sid>5ccf81e5d5beedf32ef8d7c3d7ac6c8c</sid><firstname>Diane</firstname><surname>Kelly</surname><name>Diane Kelly</name><active>true</active><ethesisStudent>false</ethesisStudent></author><author><sid>e563ed4e1c7db8d1e131fb78a5f8d0d5</sid><ORCID>0000-0002-3855-4194</ORCID><firstname>Josie</firstname><surname>Parker</surname><name>Josie Parker</name><active>true</active><ethesisStudent>false</ethesisStudent></author><author><sid>6c495cb489b67bc9bb3f746975c4ff19</sid><firstname>Claire</firstname><surname>Hull</surname><name>Claire Hull</name><active>true</active><ethesisStudent>false</ethesisStudent></author><author><sid>f066e233e8d0136c9f547b86fa43747f</sid><ORCID>0000-0003-0183-8334</ORCID><firstname>Andrew</firstname><surname>Warrilow</surname><name>Andrew Warrilow</name><active>true</active><ethesisStudent>false</ethesisStudent></author></swanseaauthors><date>2014-10-06</date><deptcode>BMS</deptcode><abstract>We have shown that Clotrimazole is an inhibitor of CYP51 in the fish pathogen Saprolegnia parasitica. Our study suggests that it may be used as a preventive treatment against the oomycete infection.</abstract><type>Journal Article</type><journal>Applied and Environmental Microbiology</journal><volume>80</volume><journalNumber>19</journalNumber><paginationStart>6154</paginationStart><paginationEnd>6166</paginationEnd><publisher/><keywords>CYP51; Saprolegnia parasitica</keywords><publishedDay>31</publishedDay><publishedMonth>12</publishedMonth><publishedYear>2014</publishedYear><publishedDate>2014-12-31</publishedDate><doi>10.1128/AEM.01195-14</doi><url/><notes/><college>COLLEGE NANME</college><department>Biomedical Sciences</department><CollegeCode>COLLEGE CODE</CollegeCode><DepartmentCode>BMS</DepartmentCode><institution>Swansea University</institution><lastEdited>2015-03-12T16:16:27.0477393</lastEdited><Created>2014-10-06T12:24:47.4723938</Created><path><level id="1">Swansea University Medical School</level><level id="2">Medicine</level></path><authors><author><firstname>A. G. S.</firstname><surname>Warrilow</surname><order>1</order></author><author><firstname>C. M.</firstname><surname>Hull</surname><order>2</order></author><author><firstname>N. J.</firstname><surname>Rolley</surname><order>3</order></author><author><firstname>J. E.</firstname><surname>Parker</surname><order>4</order></author><author><firstname>W. D.</firstname><surname>Nes</surname><order>5</order></author><author><firstname>S. N.</firstname><surname>Smith</surname><order>6</order></author><author><firstname>D. E.</firstname><surname>Kelly</surname><order>7</order></author><author><firstname>S. L.</firstname><surname>Kelly</surname><order>8</order></author><author><firstname>Steven</firstname><surname>Kelly</surname><orcid>0000-0001-7991-5040</orcid><order>9</order></author><author><firstname>Diane</firstname><surname>Kelly</surname><order>10</order></author><author><firstname>Josie</firstname><surname>Parker</surname><orcid>0000-0002-3855-4194</orcid><order>11</order></author><author><firstname>Claire</firstname><surname>Hull</surname><order>12</order></author><author><firstname>Andrew</firstname><surname>Warrilow</surname><orcid>0000-0003-0183-8334</orcid><order>13</order></author></authors><documents/><OutputDurs/></rfc1807>
spelling 2015-03-12T16:16:27.0477393 v2 18616 2014-10-06 Clotrimazole as a Potent Agent for Treating the Oomycete Fish Pathogen Saprolegnia parasitica through Inhibition of Sterol 14 -Demethylase (CYP51) b17cebaf09b4d737b9378a3581e3de93 0000-0001-7991-5040 Steven Kelly Steven Kelly true false 5ccf81e5d5beedf32ef8d7c3d7ac6c8c Diane Kelly Diane Kelly true false e563ed4e1c7db8d1e131fb78a5f8d0d5 0000-0002-3855-4194 Josie Parker Josie Parker true false 6c495cb489b67bc9bb3f746975c4ff19 Claire Hull Claire Hull true false f066e233e8d0136c9f547b86fa43747f 0000-0003-0183-8334 Andrew Warrilow Andrew Warrilow true false 2014-10-06 BMS We have shown that Clotrimazole is an inhibitor of CYP51 in the fish pathogen Saprolegnia parasitica. Our study suggests that it may be used as a preventive treatment against the oomycete infection. Journal Article Applied and Environmental Microbiology 80 19 6154 6166 CYP51; Saprolegnia parasitica 31 12 2014 2014-12-31 10.1128/AEM.01195-14 COLLEGE NANME Biomedical Sciences COLLEGE CODE BMS Swansea University 2015-03-12T16:16:27.0477393 2014-10-06T12:24:47.4723938 Swansea University Medical School Medicine A. G. S. Warrilow 1 C. M. Hull 2 N. J. Rolley 3 J. E. Parker 4 W. D. Nes 5 S. N. Smith 6 D. E. Kelly 7 S. L. Kelly 8 Steven Kelly 0000-0001-7991-5040 9 Diane Kelly 10 Josie Parker 0000-0002-3855-4194 11 Claire Hull 12 Andrew Warrilow 0000-0003-0183-8334 13
title Clotrimazole as a Potent Agent for Treating the Oomycete Fish Pathogen Saprolegnia parasitica through Inhibition of Sterol 14 -Demethylase (CYP51)
spellingShingle Clotrimazole as a Potent Agent for Treating the Oomycete Fish Pathogen Saprolegnia parasitica through Inhibition of Sterol 14 -Demethylase (CYP51)
Steven, Kelly
Diane, Kelly
Josie, Parker
Claire, Hull
Andrew, Warrilow
title_short Clotrimazole as a Potent Agent for Treating the Oomycete Fish Pathogen Saprolegnia parasitica through Inhibition of Sterol 14 -Demethylase (CYP51)
title_full Clotrimazole as a Potent Agent for Treating the Oomycete Fish Pathogen Saprolegnia parasitica through Inhibition of Sterol 14 -Demethylase (CYP51)
title_fullStr Clotrimazole as a Potent Agent for Treating the Oomycete Fish Pathogen Saprolegnia parasitica through Inhibition of Sterol 14 -Demethylase (CYP51)
title_full_unstemmed Clotrimazole as a Potent Agent for Treating the Oomycete Fish Pathogen Saprolegnia parasitica through Inhibition of Sterol 14 -Demethylase (CYP51)
title_sort Clotrimazole as a Potent Agent for Treating the Oomycete Fish Pathogen Saprolegnia parasitica through Inhibition of Sterol 14 -Demethylase (CYP51)
author_id_str_mv b17cebaf09b4d737b9378a3581e3de93
5ccf81e5d5beedf32ef8d7c3d7ac6c8c
e563ed4e1c7db8d1e131fb78a5f8d0d5
6c495cb489b67bc9bb3f746975c4ff19
f066e233e8d0136c9f547b86fa43747f
author_id_fullname_str_mv b17cebaf09b4d737b9378a3581e3de93_***_Steven, Kelly
5ccf81e5d5beedf32ef8d7c3d7ac6c8c_***_Diane, Kelly
e563ed4e1c7db8d1e131fb78a5f8d0d5_***_Josie, Parker
6c495cb489b67bc9bb3f746975c4ff19_***_Claire, Hull
f066e233e8d0136c9f547b86fa43747f_***_Andrew, Warrilow
author Steven, Kelly
Diane, Kelly
Josie, Parker
Claire, Hull
Andrew, Warrilow
author2 A. G. S. Warrilow
C. M. Hull
N. J. Rolley
J. E. Parker
W. D. Nes
S. N. Smith
D. E. Kelly
S. L. Kelly
Steven Kelly
Diane Kelly
Josie Parker
Claire Hull
Andrew Warrilow
format Journal article
container_title Applied and Environmental Microbiology
container_volume 80
container_issue 19
container_start_page 6154
publishDate 2014
institution Swansea University
doi_str_mv 10.1128/AEM.01195-14
college_str Swansea University Medical School
hierarchytype
hierarchy_top_id swanseauniversitymedicalschool
hierarchy_top_title Swansea University Medical School
hierarchy_parent_id swanseauniversitymedicalschool
hierarchy_parent_title Swansea University Medical School
department_str Medicine{{{_:::_}}}Swansea University Medical School{{{_:::_}}}Medicine
document_store_str 0
active_str 0
description We have shown that Clotrimazole is an inhibitor of CYP51 in the fish pathogen Saprolegnia parasitica. Our study suggests that it may be used as a preventive treatment against the oomycete infection.
published_date 2014-12-31T03:32:27Z
_version_ 1697071966937153536
score 10.787768