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Clotrimazole as a Potent Agent for Treating the Oomycete Fish Pathogen Saprolegnia parasitica through Inhibition of Sterol 14 -Demethylase (CYP51)

Andrew Warrilow, Claire Hull, N. J. Rolley, Josie Parker, W. D. Nes, S. N. Smith, Diane Kelly, Steven Kelly Orcid Logo

Applied and Environmental Microbiology, Volume: 80, Issue: 19, Pages: 6154 - 6166

Swansea University Authors: Andrew Warrilow, Claire Hull, Josie Parker, Diane Kelly, Steven Kelly Orcid Logo

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DOI (Published version): 10.1128/AEM.01195-14

Abstract

We have shown that Clotrimazole is an inhibitor of CYP51 in the fish pathogen Saprolegnia parasitica. Our study suggests that it may be used as a preventive treatment against the oomycete infection.

Published in: Applied and Environmental Microbiology
Published: 2014
URI: https://cronfa.swan.ac.uk/Record/cronfa18616
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first_indexed 2014-10-07T01:58:15Z
last_indexed 2021-10-27T02:31:36Z
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spelling 2021-10-26T15:35:20.7096777 v2 18616 2014-10-06 Clotrimazole as a Potent Agent for Treating the Oomycete Fish Pathogen Saprolegnia parasitica through Inhibition of Sterol 14 -Demethylase (CYP51) f066e233e8d0136c9f547b86fa43747f Andrew Warrilow Andrew Warrilow true false 6c495cb489b67bc9bb3f746975c4ff19 Claire Hull Claire Hull true false e563ed4e1c7db8d1e131fb78a5f8d0d5 Josie Parker Josie Parker true false 5ccf81e5d5beedf32ef8d7c3d7ac6c8c Diane Kelly Diane Kelly true false b17cebaf09b4d737b9378a3581e3de93 0000-0001-7991-5040 Steven Kelly Steven Kelly true false 2014-10-06 FGMHL We have shown that Clotrimazole is an inhibitor of CYP51 in the fish pathogen Saprolegnia parasitica. Our study suggests that it may be used as a preventive treatment against the oomycete infection. Journal Article Applied and Environmental Microbiology 80 19 6154 6166 CYP51; Saprolegnia parasitica 31 12 2014 2014-12-31 10.1128/AEM.01195-14 COLLEGE NANME Medicine, Health and Life Science - Faculty COLLEGE CODE FGMHL Swansea University 2021-10-26T15:35:20.7096777 2014-10-06T12:24:47.4723938 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medicine Andrew Warrilow 1 Claire Hull 2 N. J. Rolley 3 Josie Parker 4 W. D. Nes 5 S. N. Smith 6 Diane Kelly 7 Steven Kelly 0000-0001-7991-5040 8
title Clotrimazole as a Potent Agent for Treating the Oomycete Fish Pathogen Saprolegnia parasitica through Inhibition of Sterol 14 -Demethylase (CYP51)
spellingShingle Clotrimazole as a Potent Agent for Treating the Oomycete Fish Pathogen Saprolegnia parasitica through Inhibition of Sterol 14 -Demethylase (CYP51)
Andrew Warrilow
Claire Hull
Josie Parker
Diane Kelly
Steven Kelly
title_short Clotrimazole as a Potent Agent for Treating the Oomycete Fish Pathogen Saprolegnia parasitica through Inhibition of Sterol 14 -Demethylase (CYP51)
title_full Clotrimazole as a Potent Agent for Treating the Oomycete Fish Pathogen Saprolegnia parasitica through Inhibition of Sterol 14 -Demethylase (CYP51)
title_fullStr Clotrimazole as a Potent Agent for Treating the Oomycete Fish Pathogen Saprolegnia parasitica through Inhibition of Sterol 14 -Demethylase (CYP51)
title_full_unstemmed Clotrimazole as a Potent Agent for Treating the Oomycete Fish Pathogen Saprolegnia parasitica through Inhibition of Sterol 14 -Demethylase (CYP51)
title_sort Clotrimazole as a Potent Agent for Treating the Oomycete Fish Pathogen Saprolegnia parasitica through Inhibition of Sterol 14 -Demethylase (CYP51)
author_id_str_mv f066e233e8d0136c9f547b86fa43747f
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author_id_fullname_str_mv f066e233e8d0136c9f547b86fa43747f_***_Andrew Warrilow
6c495cb489b67bc9bb3f746975c4ff19_***_Claire Hull
e563ed4e1c7db8d1e131fb78a5f8d0d5_***_Josie Parker
5ccf81e5d5beedf32ef8d7c3d7ac6c8c_***_Diane Kelly
b17cebaf09b4d737b9378a3581e3de93_***_Steven Kelly
author Andrew Warrilow
Claire Hull
Josie Parker
Diane Kelly
Steven Kelly
author2 Andrew Warrilow
Claire Hull
N. J. Rolley
Josie Parker
W. D. Nes
S. N. Smith
Diane Kelly
Steven Kelly
format Journal article
container_title Applied and Environmental Microbiology
container_volume 80
container_issue 19
container_start_page 6154
publishDate 2014
institution Swansea University
doi_str_mv 10.1128/AEM.01195-14
college_str Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str Swansea University Medical School - Medicine{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Medicine
document_store_str 0
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description We have shown that Clotrimazole is an inhibitor of CYP51 in the fish pathogen Saprolegnia parasitica. Our study suggests that it may be used as a preventive treatment against the oomycete infection.
published_date 2014-12-31T03:21:50Z
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score 11.016235

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