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Highly sensitive covalently functionalised integrated silicon nanowire biosensor devices for detection of cancer risk biomarker

M.A. Mohd Azmi, Zari Tehrani Orcid Logo, R.P. Lewis, K.-A.D. Walker, D.R. Jones, D.R. Daniels, Shareen Doak Orcid Logo, Owen Guy Orcid Logo

Biosensors and Bioelectronics, Volume: 52, Pages: 216 - 224

Swansea University Authors: Zari Tehrani Orcid Logo, Shareen Doak Orcid Logo, Owen Guy Orcid Logo

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DOI (Published version): 10.1016/j.bios.2013.08.030

Abstract

In this article we present ultra-sensitive, silicon nanowire (SiNW)-based biosensor devices for the detection of disease biomarkers. An electrochemically induced functionalisation method has been employed to graft antibodies targeted against the prostate cancer risk biomarker 8-hydroxydeoxyguanosine...

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Published in: Biosensors and Bioelectronics
ISSN: 0956-5663
Published: 2014
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URI: https://cronfa.swan.ac.uk/Record/cronfa19740
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first_indexed 2014-12-13T02:56:45Z
last_indexed 2020-07-01T18:30:34Z
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spelling 2020-07-01T16:13:34.7694127 v2 19740 2014-12-12 Highly sensitive covalently functionalised integrated silicon nanowire biosensor devices for detection of cancer risk biomarker fd8e614b01086804c80fbafa6fa6aaf5 0000-0002-5069-7921 Zari Tehrani Zari Tehrani true false 8f70286908f67238a527a98cbf66d387 0000-0002-6753-1987 Shareen Doak Shareen Doak true false c7fa5949b8528e048c5b978005f66794 0000-0002-6449-4033 Owen Guy Owen Guy true false 2014-12-12 CHEG In this article we present ultra-sensitive, silicon nanowire (SiNW)-based biosensor devices for the detection of disease biomarkers. An electrochemically induced functionalisation method has been employed to graft antibodies targeted against the prostate cancer risk biomarker 8-hydroxydeoxyguanosine (8-OHdG) to SiNW surfaces. The antibody-functionalised SiNW sensor has been used to detect binding of the 8-OHdG biomarker to the SiNW surface within seconds of exposure. Detection of 8-OHdG concentrations as low as 1 ng/ml (3.5 nM) has been demonstrated. The active device has been bonded to a disposable printed circuit which can be inserted into an electronic readout system as part of an integrated Point of Care (POC) diagnostic. The speed, sensitivity and ease of detection of biomarkers using SiNW sensors render them ideal for eventual POC diagnostics. Journal Article Biosensors and Bioelectronics 52 216 224 0956-5663 15 2 2014 2014-02-15 10.1016/j.bios.2013.08.030 COLLEGE NANME Chemical Engineering COLLEGE CODE CHEG Swansea University 2020-07-01T16:13:34.7694127 2014-12-12T14:52:13.6872908 Faculty of Science and Engineering School of Engineering and Applied Sciences - Chemistry M.A. Mohd Azmi 1 Zari Tehrani 0000-0002-5069-7921 2 R.P. Lewis 3 K.-A.D. Walker 4 D.R. Jones 5 D.R. Daniels 6 Shareen Doak 0000-0002-6753-1987 7 Owen Guy 0000-0002-6449-4033 8 0019740-21122017100126.pdf 19740.pdf 2017-12-21T10:01:26.3670000 Output 726953 application/pdf Accepted Manuscript true 2015-05-07T00:00:00.0000000 false eng
title Highly sensitive covalently functionalised integrated silicon nanowire biosensor devices for detection of cancer risk biomarker
spellingShingle Highly sensitive covalently functionalised integrated silicon nanowire biosensor devices for detection of cancer risk biomarker
Zari Tehrani
Shareen Doak
Owen Guy
title_short Highly sensitive covalently functionalised integrated silicon nanowire biosensor devices for detection of cancer risk biomarker
title_full Highly sensitive covalently functionalised integrated silicon nanowire biosensor devices for detection of cancer risk biomarker
title_fullStr Highly sensitive covalently functionalised integrated silicon nanowire biosensor devices for detection of cancer risk biomarker
title_full_unstemmed Highly sensitive covalently functionalised integrated silicon nanowire biosensor devices for detection of cancer risk biomarker
title_sort Highly sensitive covalently functionalised integrated silicon nanowire biosensor devices for detection of cancer risk biomarker
author_id_str_mv fd8e614b01086804c80fbafa6fa6aaf5
8f70286908f67238a527a98cbf66d387
c7fa5949b8528e048c5b978005f66794
author_id_fullname_str_mv fd8e614b01086804c80fbafa6fa6aaf5_***_Zari Tehrani
8f70286908f67238a527a98cbf66d387_***_Shareen Doak
c7fa5949b8528e048c5b978005f66794_***_Owen Guy
author Zari Tehrani
Shareen Doak
Owen Guy
author2 M.A. Mohd Azmi
Zari Tehrani
R.P. Lewis
K.-A.D. Walker
D.R. Jones
D.R. Daniels
Shareen Doak
Owen Guy
format Journal article
container_title Biosensors and Bioelectronics
container_volume 52
container_start_page 216
publishDate 2014
institution Swansea University
issn 0956-5663
doi_str_mv 10.1016/j.bios.2013.08.030
college_str Faculty of Science and Engineering
hierarchytype
hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Engineering and Applied Sciences - Chemistry{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Engineering and Applied Sciences - Chemistry
document_store_str 1
active_str 0
description In this article we present ultra-sensitive, silicon nanowire (SiNW)-based biosensor devices for the detection of disease biomarkers. An electrochemically induced functionalisation method has been employed to graft antibodies targeted against the prostate cancer risk biomarker 8-hydroxydeoxyguanosine (8-OHdG) to SiNW surfaces. The antibody-functionalised SiNW sensor has been used to detect binding of the 8-OHdG biomarker to the SiNW surface within seconds of exposure. Detection of 8-OHdG concentrations as low as 1 ng/ml (3.5 nM) has been demonstrated. The active device has been bonded to a disposable printed circuit which can be inserted into an electronic readout system as part of an integrated Point of Care (POC) diagnostic. The speed, sensitivity and ease of detection of biomarkers using SiNW sensors render them ideal for eventual POC diagnostics.
published_date 2014-02-15T03:23:15Z
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