Journal article 1502 views
A Cholesterol Biosensor Based on the NIR Electrogenerated-Chemiluminescence (ECL) of Water-Soluble CdSeTe/ZnS Quantum Dots
Alasdair J. Stewart,
Emmet J. O’Reilly,
Roisin D. Moriarty,
Paolo Bertoncello 
,
Tia E. Keyes,
Robert J. Forster,
Lynn Dennany
,
Tia E. Keyes,
Robert J. Forster,
Lynn Dennany
Electrochimica Acta, Volume: 157, Pages: 8 - 14
Swansea University Author:
Paolo Bertoncello
Full text not available from this repository: check for access using links below.
DOI (Published version): 10.1016/j.electacta.2015.01.073
Abstract
This contribution examines the application of near infra-red (NIR) quantum dot (QD) containing films for cholesterol detection. Water-soluble, 2-(dimethylamino) ethanthiol (DAET) protected 800 nm CdSeTe/ZnS core-shell QDs were prepared and incorporated into a chitosan film. The NIR electrogenerated...
| Published in: | Electrochimica Acta |
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| ISSN: | 0013-4686 |
| Published: |
2015
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| Online Access: |
Check full text
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| URI: | https://cronfa.swan.ac.uk/Record/cronfa21194 |
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| Abstract: |
This contribution examines the application of near infra-red (NIR) quantum dot (QD) containing films for cholesterol detection. Water-soluble, 2-(dimethylamino) ethanthiol (DAET) protected 800 nm CdSeTe/ZnS core-shell QDs were prepared and incorporated into a chitosan film. The NIR electrogenerated chemiluminescence (ECL) of the QD/chitosan films upon reaction with H2O2 co-reactant (produced as a by-product of cholesterol oxidase-catalysed oxidation of cholesterol) gave a strong ECL signal at −1.35 V vs. Ag/AgCl. The sensor displayed a linear response over the clinically relevant range (0.25 ≤ [cholesterol] ≤ 5 mM) allowing the rapid detection of cholesterol and providing a platform for future development. Significantly, this NIR emission has been shown to exhibit excellent penetrability through biological samples, and will likely be at the forefront of development in the biosensing and imaging fields for the foreseeable future. |
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| Keywords: |
biosnesors, cholesterol |
| College: |
Faculty of Science and Engineering |
| Start Page: |
8 |
| End Page: |
14 |