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A Cholesterol Biosensor Based on the NIR Electrogenerated-Chemiluminescence (ECL) of Water-Soluble CdSeTe/ZnS Quantum Dots

Alasdair J. Stewart, Emmet J. O’Reilly, Roisin D. Moriarty, Paolo Bertoncello Orcid Logo, Tia E. Keyes, Robert J. Forster, Lynn Dennany

Electrochimica Acta, Volume: 157, Pages: 8 - 14

Swansea University Author: Paolo Bertoncello Orcid Logo

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DOI (Published version): 10.1016/j.electacta.2015.01.073

Abstract

This contribution examines the application of near infra-red (NIR) quantum dot (QD) containing films for cholesterol detection. Water-soluble, 2-(dimethylamino) ethanthiol (DAET) protected 800 nm CdSeTe/ZnS core-shell QDs were prepared and incorporated into a chitosan film. The NIR electrogenerated...

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Published in: Electrochimica Acta
ISSN: 0013-4686
Published: 2015
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URI: https://cronfa.swan.ac.uk/Record/cronfa21194
first_indexed 2015-05-08T02:10:40Z
last_indexed 2019-10-01T13:26:54Z
id cronfa21194
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spelling 2019-10-01T12:26:37.3160100 v2 21194 2015-05-07 A Cholesterol Biosensor Based on the NIR Electrogenerated-Chemiluminescence (ECL) of Water-Soluble CdSeTe/ZnS Quantum Dots ad352842aa5fe9c1947bd24ff61816c8 0000-0002-6557-7885 Paolo Bertoncello Paolo Bertoncello true false 2015-05-07 EAAS This contribution examines the application of near infra-red (NIR) quantum dot (QD) containing films for cholesterol detection. Water-soluble, 2-(dimethylamino) ethanthiol (DAET) protected 800 nm CdSeTe/ZnS core-shell QDs were prepared and incorporated into a chitosan film. The NIR electrogenerated chemiluminescence (ECL) of the QD/chitosan films upon reaction with H2O2 co-reactant (produced as a by-product of cholesterol oxidase-catalysed oxidation of cholesterol) gave a strong ECL signal at −1.35 V vs. Ag/AgCl. The sensor displayed a linear response over the clinically relevant range (0.25 ≤ [cholesterol] ≤ 5 mM) allowing the rapid detection of cholesterol and providing a platform for future development. Significantly, this NIR emission has been shown to exhibit excellent penetrability through biological samples, and will likely be at the forefront of development in the biosensing and imaging fields for the foreseeable future. Journal Article Electrochimica Acta 157 8 14 0013-4686 biosnesors, cholesterol 1 3 2015 2015-03-01 10.1016/j.electacta.2015.01.073 COLLEGE NANME Engineering and Applied Sciences School COLLEGE CODE EAAS Swansea University 2019-10-01T12:26:37.3160100 2015-05-07T08:28:26.5066160 Faculty of Science and Engineering School of Engineering and Applied Sciences - Chemical Engineering Alasdair J. Stewart 1 Emmet J. O’Reilly 2 Roisin D. Moriarty 3 Paolo Bertoncello 0000-0002-6557-7885 4 Tia E. Keyes 5 Robert J. Forster 6 Lynn Dennany 7
title A Cholesterol Biosensor Based on the NIR Electrogenerated-Chemiluminescence (ECL) of Water-Soluble CdSeTe/ZnS Quantum Dots
spellingShingle A Cholesterol Biosensor Based on the NIR Electrogenerated-Chemiluminescence (ECL) of Water-Soluble CdSeTe/ZnS Quantum Dots
Paolo Bertoncello
title_short A Cholesterol Biosensor Based on the NIR Electrogenerated-Chemiluminescence (ECL) of Water-Soluble CdSeTe/ZnS Quantum Dots
title_full A Cholesterol Biosensor Based on the NIR Electrogenerated-Chemiluminescence (ECL) of Water-Soluble CdSeTe/ZnS Quantum Dots
title_fullStr A Cholesterol Biosensor Based on the NIR Electrogenerated-Chemiluminescence (ECL) of Water-Soluble CdSeTe/ZnS Quantum Dots
title_full_unstemmed A Cholesterol Biosensor Based on the NIR Electrogenerated-Chemiluminescence (ECL) of Water-Soluble CdSeTe/ZnS Quantum Dots
title_sort A Cholesterol Biosensor Based on the NIR Electrogenerated-Chemiluminescence (ECL) of Water-Soluble CdSeTe/ZnS Quantum Dots
author_id_str_mv ad352842aa5fe9c1947bd24ff61816c8
author_id_fullname_str_mv ad352842aa5fe9c1947bd24ff61816c8_***_Paolo Bertoncello
author Paolo Bertoncello
author2 Alasdair J. Stewart
Emmet J. O’Reilly
Roisin D. Moriarty
Paolo Bertoncello
Tia E. Keyes
Robert J. Forster
Lynn Dennany
format Journal article
container_title Electrochimica Acta
container_volume 157
container_start_page 8
publishDate 2015
institution Swansea University
issn 0013-4686
doi_str_mv 10.1016/j.electacta.2015.01.073
college_str Faculty of Science and Engineering
hierarchytype
hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Engineering and Applied Sciences - Chemical Engineering{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Engineering and Applied Sciences - Chemical Engineering
document_store_str 0
active_str 0
description This contribution examines the application of near infra-red (NIR) quantum dot (QD) containing films for cholesterol detection. Water-soluble, 2-(dimethylamino) ethanthiol (DAET) protected 800 nm CdSeTe/ZnS core-shell QDs were prepared and incorporated into a chitosan film. The NIR electrogenerated chemiluminescence (ECL) of the QD/chitosan films upon reaction with H2O2 co-reactant (produced as a by-product of cholesterol oxidase-catalysed oxidation of cholesterol) gave a strong ECL signal at −1.35 V vs. Ag/AgCl. The sensor displayed a linear response over the clinically relevant range (0.25 ≤ [cholesterol] ≤ 5 mM) allowing the rapid detection of cholesterol and providing a platform for future development. Significantly, this NIR emission has been shown to exhibit excellent penetrability through biological samples, and will likely be at the forefront of development in the biosensing and imaging fields for the foreseeable future.
published_date 2015-03-01T12:43:09Z
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score 11.090811

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