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Graphene Field Effect Transistors for Biomedical Applications: Current Status and Future Prospects
Diagnostics, Volume: 7, Issue: 3, Start page: 45
Swansea University Authors: Owen Guy , Anitha Devadoss
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DOI (Published version): 10.3390/diagnostics7030045
Abstract
Since the discovery of the two-dimensional (2D) carbon material, graphene, just over a decade ago, the development of graphene-based field effect transistors (G-FETs) has become a widely researched area, particularly for use in point-of-care biomedical applications. G-FETs are particularly attractiv...
Published in: | Diagnostics |
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ISSN: | 2075-4418 |
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2017
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URI: | https://cronfa.swan.ac.uk/Record/cronfa34812 |
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2017-10-03T16:19:18.2363556 v2 34812 2017-07-28 Graphene Field Effect Transistors for Biomedical Applications: Current Status and Future Prospects c7fa5949b8528e048c5b978005f66794 0000-0002-6449-4033 Owen Guy Owen Guy true false a01150750f1c8eccbfeebffdde3fe8a1 0000-0002-8052-1820 Anitha Devadoss Anitha Devadoss true false 2017-07-28 CHEM Since the discovery of the two-dimensional (2D) carbon material, graphene, just over a decade ago, the development of graphene-based field effect transistors (G-FETs) has become a widely researched area, particularly for use in point-of-care biomedical applications. G-FETs are particularly attractive as next generation bioelectronics due to their mass-scalability and low cost of the technology’s manufacture. Furthermore, G-FETs offer the potential to complete label-free, rapid, and highly sensitive analysis coupled with a high sample throughput. These properties, coupled with the potential for integration into portable instrumentation, contribute to G-FETs’ suitability for point-of-care diagnostics. This review focuses on elucidating the recent developments in the field of G-FET sensors that act on a bioaffinity basis, whereby a binding event between a bioreceptor and the target analyte is transduced into an electrical signal at the G-FET surface. Recognizing and quantifying these target analytes accurately and reliably is essential in diagnosing many diseases, therefore it is vital to design the G-FET with care. Taking into account some limitations of the sensor platform, such as Debye–Hükel screening and device surface area, is fundamental in developing improved bioelectronics for applications in the clinical setting. This review highlights some efforts undertaken in facing these limitations in order to bring G-FET development for biomedical applications forward. Journal Article Diagnostics 7 3 45 2075-4418 G-FET (graphene-based field effect transistors); DNA; aptamer; Debye length; antigen binding fragment; Dirac voltage; point-of-care 26 7 2017 2017-07-26 10.3390/diagnostics7030045 http://www.mdpi.com/2075-4418/7/3/45 COLLEGE NANME Chemistry COLLEGE CODE CHEM Swansea University 2017-10-03T16:19:18.2363556 2017-07-28T09:05:33.7833888 Faculty of Science and Engineering School of Engineering and Applied Sciences - Chemistry Rhiannon Forsyth 1 Owen Guy 0000-0002-6449-4033 2 Anitha Devadoss 0000-0002-8052-1820 3 0034812-03082017102948.pdf forsyth2017.pdf 2017-08-03T10:29:48.6670000 Output 4909478 application/pdf Version of Record true 2017-08-03T00:00:00.0000000 true eng |
title |
Graphene Field Effect Transistors for Biomedical Applications: Current Status and Future Prospects |
spellingShingle |
Graphene Field Effect Transistors for Biomedical Applications: Current Status and Future Prospects Owen Guy Anitha Devadoss |
title_short |
Graphene Field Effect Transistors for Biomedical Applications: Current Status and Future Prospects |
title_full |
Graphene Field Effect Transistors for Biomedical Applications: Current Status and Future Prospects |
title_fullStr |
Graphene Field Effect Transistors for Biomedical Applications: Current Status and Future Prospects |
title_full_unstemmed |
Graphene Field Effect Transistors for Biomedical Applications: Current Status and Future Prospects |
title_sort |
Graphene Field Effect Transistors for Biomedical Applications: Current Status and Future Prospects |
author_id_str_mv |
c7fa5949b8528e048c5b978005f66794 a01150750f1c8eccbfeebffdde3fe8a1 |
author_id_fullname_str_mv |
c7fa5949b8528e048c5b978005f66794_***_Owen Guy a01150750f1c8eccbfeebffdde3fe8a1_***_Anitha Devadoss |
author |
Owen Guy Anitha Devadoss |
author2 |
Rhiannon Forsyth Owen Guy Anitha Devadoss |
format |
Journal article |
container_title |
Diagnostics |
container_volume |
7 |
container_issue |
3 |
container_start_page |
45 |
publishDate |
2017 |
institution |
Swansea University |
issn |
2075-4418 |
doi_str_mv |
10.3390/diagnostics7030045 |
college_str |
Faculty of Science and Engineering |
hierarchytype |
|
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facultyofscienceandengineering |
hierarchy_top_title |
Faculty of Science and Engineering |
hierarchy_parent_id |
facultyofscienceandengineering |
hierarchy_parent_title |
Faculty of Science and Engineering |
department_str |
School of Engineering and Applied Sciences - Chemistry{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Engineering and Applied Sciences - Chemistry |
url |
http://www.mdpi.com/2075-4418/7/3/45 |
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description |
Since the discovery of the two-dimensional (2D) carbon material, graphene, just over a decade ago, the development of graphene-based field effect transistors (G-FETs) has become a widely researched area, particularly for use in point-of-care biomedical applications. G-FETs are particularly attractive as next generation bioelectronics due to their mass-scalability and low cost of the technology’s manufacture. Furthermore, G-FETs offer the potential to complete label-free, rapid, and highly sensitive analysis coupled with a high sample throughput. These properties, coupled with the potential for integration into portable instrumentation, contribute to G-FETs’ suitability for point-of-care diagnostics. This review focuses on elucidating the recent developments in the field of G-FET sensors that act on a bioaffinity basis, whereby a binding event between a bioreceptor and the target analyte is transduced into an electrical signal at the G-FET surface. Recognizing and quantifying these target analytes accurately and reliably is essential in diagnosing many diseases, therefore it is vital to design the G-FET with care. Taking into account some limitations of the sensor platform, such as Debye–Hükel screening and device surface area, is fundamental in developing improved bioelectronics for applications in the clinical setting. This review highlights some efforts undertaken in facing these limitations in order to bring G-FET development for biomedical applications forward. |
published_date |
2017-07-26T03:43:12Z |
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1763752010045194240 |
score |
11.028774 |