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Rapid, low cost prototyping of transdermal devices for personal healthcare monitoring / Sanjiv Sharma; Anwer Saeed; Christopher Johnson; Nikolaj Gadegaard; Anthony EG Cass

Sensing and Bio-Sensing Research, Volume: 13, Pages: 104 - 108

Swansea University Author: Sanjiv, Sharma

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Abstract

The next generation of devices for personal healthcare monitoring will comprise molecular sensors to monitor analytes of interest in the skin compartment. Transdermal devices based on microneedles offer an excellent opportunity to explore the dynamics of molecular markers in the interstitial fluid,...

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Published in: Sensing and Bio-Sensing Research
ISSN: 2214-1804
Published: Elsevier BV 2017
Online Access: Check full text

URI: https://cronfa.swan.ac.uk/Record/cronfa36253
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Abstract: The next generation of devices for personal healthcare monitoring will comprise molecular sensors to monitor analytes of interest in the skin compartment. Transdermal devices based on microneedles offer an excellent opportunity to explore the dynamics of molecular markers in the interstitial fluid, however good acceptability of these next generation devices will require several technical problems associated with current commercially available wearable sensors to be overcome. These particularly include reliability, comfort and cost. An essential pre-requisite for transdermal molecular sensing devices is that they can be fabricated using scalable technologies which are cost effective.We present here a minimally invasive microneedle array as a continuous monitoring platform technology. Method for scalable fabrication of these structures is presented. The microneedle arrays were characterised mechanically and were shown to penetrate human skin under moderate thumb pressure. They were then functionalised and evaluated as glucose, lactate and theophylline biosensors. The results suggest that this technology can be employed in the measurement of metabolites, therapeutic drugs and biomarkers and could have an important role to play in the management of chronic diseases.
Keywords: MicroneedlesMinimally invasive sensorsContinuous glucose monitoring (CGM)Continuous lactate monitoring (CLM)Interstitial therapeutic drug monitoring (iTDM)
College: College of Engineering
Start Page: 104
End Page: 108