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Rapid, low cost prototyping of transdermal devices for personal healthcare monitoring

Sanjiv Sharma Orcid Logo, Anwer Saeed, Christopher Johnson, Nikolaj Gadegaard, Anthony EG Cass

Sensing and Bio-Sensing Research, Volume: 13, Pages: 104 - 108

Swansea University Author: Sanjiv Sharma Orcid Logo

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DOI (Published version): 10.1016/j.sbsr.2016.10.004

Abstract

The next generation of devices for personal healthcare monitoring will comprise molecular sensors to monitor analytes of interest in the skin compartment. Transdermal devices based on microneedles offer an excellent opportunity to explore the dynamics of molecular markers in the interstitial fluid,...

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Published in: Sensing and Bio-Sensing Research
ISSN: 2214-1804
Published: Elsevier BV 2017
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URI: https://cronfa.swan.ac.uk/Record/cronfa36253
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spelling 2020-07-14T12:15:14.0894789 v2 36253 2017-10-25 Rapid, low cost prototyping of transdermal devices for personal healthcare monitoring b6b7506358522f607b171ec9c94757b7 0000-0003-3828-737X Sanjiv Sharma Sanjiv Sharma true false 2017-10-25 MEDE The next generation of devices for personal healthcare monitoring will comprise molecular sensors to monitor analytes of interest in the skin compartment. Transdermal devices based on microneedles offer an excellent opportunity to explore the dynamics of molecular markers in the interstitial fluid, however good acceptability of these next generation devices will require several technical problems associated with current commercially available wearable sensors to be overcome. These particularly include reliability, comfort and cost. An essential pre-requisite for transdermal molecular sensing devices is that they can be fabricated using scalable technologies which are cost effective.We present here a minimally invasive microneedle array as a continuous monitoring platform technology. Method for scalable fabrication of these structures is presented. The microneedle arrays were characterised mechanically and were shown to penetrate human skin under moderate thumb pressure. They were then functionalised and evaluated as glucose, lactate and theophylline biosensors. The results suggest that this technology can be employed in the measurement of metabolites, therapeutic drugs and biomarkers and could have an important role to play in the management of chronic diseases. Journal Article Sensing and Bio-Sensing Research 13 104 108 Elsevier BV 2214-1804 MicroneedlesMinimally invasive sensorsContinuous glucose monitoring (CGM)Continuous lactate monitoring (CLM)Interstitial therapeutic drug monitoring (iTDM) 30 4 2017 2017-04-30 10.1016/j.sbsr.2016.10.004 COLLEGE NANME Biomedical Engineering COLLEGE CODE MEDE Swansea University 2020-07-14T12:15:14.0894789 2017-10-25T14:06:20.3857332 Faculty of Science and Engineering School of Engineering and Applied Sciences - Biomedical Engineering Sanjiv Sharma 0000-0003-3828-737X 1 Anwer Saeed 2 Christopher Johnson 3 Nikolaj Gadegaard 4 Anthony EG Cass 5 0036253-25102017155615.pdf sharma2017.pdf 2017-10-25T15:56:15.6430000 Output 1184529 application/pdf Version of Record true 2017-10-25T00:00:00.0000000 This is an open access article under the CC BY license true eng https://creativecommons.org/licenses/by/4.0/
title Rapid, low cost prototyping of transdermal devices for personal healthcare monitoring
spellingShingle Rapid, low cost prototyping of transdermal devices for personal healthcare monitoring
Sanjiv Sharma
title_short Rapid, low cost prototyping of transdermal devices for personal healthcare monitoring
title_full Rapid, low cost prototyping of transdermal devices for personal healthcare monitoring
title_fullStr Rapid, low cost prototyping of transdermal devices for personal healthcare monitoring
title_full_unstemmed Rapid, low cost prototyping of transdermal devices for personal healthcare monitoring
title_sort Rapid, low cost prototyping of transdermal devices for personal healthcare monitoring
author_id_str_mv b6b7506358522f607b171ec9c94757b7
author_id_fullname_str_mv b6b7506358522f607b171ec9c94757b7_***_Sanjiv Sharma
author Sanjiv Sharma
author2 Sanjiv Sharma
Anwer Saeed
Christopher Johnson
Nikolaj Gadegaard
Anthony EG Cass
format Journal article
container_title Sensing and Bio-Sensing Research
container_volume 13
container_start_page 104
publishDate 2017
institution Swansea University
issn 2214-1804
doi_str_mv 10.1016/j.sbsr.2016.10.004
publisher Elsevier BV
college_str Faculty of Science and Engineering
hierarchytype
hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Engineering and Applied Sciences - Biomedical Engineering{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Engineering and Applied Sciences - Biomedical Engineering
document_store_str 1
active_str 0
description The next generation of devices for personal healthcare monitoring will comprise molecular sensors to monitor analytes of interest in the skin compartment. Transdermal devices based on microneedles offer an excellent opportunity to explore the dynamics of molecular markers in the interstitial fluid, however good acceptability of these next generation devices will require several technical problems associated with current commercially available wearable sensors to be overcome. These particularly include reliability, comfort and cost. An essential pre-requisite for transdermal molecular sensing devices is that they can be fabricated using scalable technologies which are cost effective.We present here a minimally invasive microneedle array as a continuous monitoring platform technology. Method for scalable fabrication of these structures is presented. The microneedle arrays were characterised mechanically and were shown to penetrate human skin under moderate thumb pressure. They were then functionalised and evaluated as glucose, lactate and theophylline biosensors. The results suggest that this technology can be employed in the measurement of metabolites, therapeutic drugs and biomarkers and could have an important role to play in the management of chronic diseases.
published_date 2017-04-30T03:45:16Z
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score 10.997933

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