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Delivering precision antimicrobial therapy through closed-loop control systems

T M Rawson, D O’Hare, P Herrero, S Sharma, L S P Moore, E de Barra, J A Roberts, A C Gordon, W Hope, P Georgiou, A E G Cass, A H Holmes, Sanjiv Sharma Orcid Logo

Journal of Antimicrobial Chemotherapy

Swansea University Author: Sanjiv Sharma Orcid Logo

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DOI (Published version): 10.1093/jac/dkx458

Abstract

Sub-optimal exposure to antimicrobial therapy is associated with poor patient outcomes and the development of antimicrobial resistance. Mechanisms for optimizing the concentration of a drug within the individual patient are under development. However, several barriers remain in realizing true indivi...

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Published in: Journal of Antimicrobial Chemotherapy
ISSN: 0305-7453 1460-2091
Published: 2017
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URI: https://cronfa.swan.ac.uk/Record/cronfa37320
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last_indexed 2020-07-21T12:56:34Z
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spelling 2020-07-21T11:50:21.6388633 v2 37320 2017-12-04 Delivering precision antimicrobial therapy through closed-loop control systems b6b7506358522f607b171ec9c94757b7 0000-0003-3828-737X Sanjiv Sharma Sanjiv Sharma true false 2017-12-04 MEDE Sub-optimal exposure to antimicrobial therapy is associated with poor patient outcomes and the development of antimicrobial resistance. Mechanisms for optimizing the concentration of a drug within the individual patient are under development. However, several barriers remain in realizing true individualization of therapy. These include problems with plasma drug sampling, availability of appropriate assays, and current mechanisms for dose adjustment. Biosensor technology offers a means of providing real-time monitoring of antimicrobials in a minimally invasive fashion. We report the potential for using microneedle biosensor technology as part of closed-loop control systems for the optimization of antimicrobial therapy in individual patients. Journal Article Journal of Antimicrobial Chemotherapy 0305-7453 1460-2091 plasma, antimicrobials, precision 4 12 2017 2017-12-04 10.1093/jac/dkx458 https://academic.oup.com/jac/advance-article/doi/10.1093/jac/dkx458/4688914 COLLEGE NANME Biomedical Engineering COLLEGE CODE MEDE Swansea University 2020-07-21T11:50:21.6388633 2017-12-04T23:22:10.0210765 Faculty of Science and Engineering School of Engineering and Applied Sciences - Biomedical Engineering T M Rawson 1 D O’Hare 2 P Herrero 3 S Sharma 4 L S P Moore 5 E de Barra 6 J A Roberts 7 A C Gordon 8 W Hope 9 P Georgiou 10 A E G Cass 11 A H Holmes 12 Sanjiv Sharma 0000-0003-3828-737X 13 37320__7277__337eb5de70e6444a997d584304a6b5f1.pdf rawson2017.pdf 2017-12-05T11:30:45.4430000 Output 236987 application/pdf Version of Record true 2017-12-05T00:00:00.0000000 false eng
title Delivering precision antimicrobial therapy through closed-loop control systems
spellingShingle Delivering precision antimicrobial therapy through closed-loop control systems
Sanjiv Sharma
title_short Delivering precision antimicrobial therapy through closed-loop control systems
title_full Delivering precision antimicrobial therapy through closed-loop control systems
title_fullStr Delivering precision antimicrobial therapy through closed-loop control systems
title_full_unstemmed Delivering precision antimicrobial therapy through closed-loop control systems
title_sort Delivering precision antimicrobial therapy through closed-loop control systems
author_id_str_mv b6b7506358522f607b171ec9c94757b7
author_id_fullname_str_mv b6b7506358522f607b171ec9c94757b7_***_Sanjiv Sharma
author Sanjiv Sharma
author2 T M Rawson
D O’Hare
P Herrero
S Sharma
L S P Moore
E de Barra
J A Roberts
A C Gordon
W Hope
P Georgiou
A E G Cass
A H Holmes
Sanjiv Sharma
format Journal article
container_title Journal of Antimicrobial Chemotherapy
publishDate 2017
institution Swansea University
issn 0305-7453
1460-2091
doi_str_mv 10.1093/jac/dkx458
college_str Faculty of Science and Engineering
hierarchytype
hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Engineering and Applied Sciences - Biomedical Engineering{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Engineering and Applied Sciences - Biomedical Engineering
url https://academic.oup.com/jac/advance-article/doi/10.1093/jac/dkx458/4688914
document_store_str 1
active_str 0
description Sub-optimal exposure to antimicrobial therapy is associated with poor patient outcomes and the development of antimicrobial resistance. Mechanisms for optimizing the concentration of a drug within the individual patient are under development. However, several barriers remain in realizing true individualization of therapy. These include problems with plasma drug sampling, availability of appropriate assays, and current mechanisms for dose adjustment. Biosensor technology offers a means of providing real-time monitoring of antimicrobials in a minimally invasive fashion. We report the potential for using microneedle biosensor technology as part of closed-loop control systems for the optimization of antimicrobial therapy in individual patients.
published_date 2017-12-04T03:46:59Z
_version_ 1763752247933534208
score 10.949775

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