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An update on oxysterol biochemistry: New discoveries in lipidomics / William, Griffiths

Biochemical and Biophysical Research Communications, Volume: 504, Issue: 3, Pages: 617 - 622

Swansea University Author: William, Griffiths

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Abstract

Oxysterols are oxidised derivatives of cholesterol or its precursors post lanosterol. They are intermediates in the biosynthesis of bile acids, steroid hormones and 1,25-dihydroxyvitamin D3. Although often considered as metabolic intermediates there is a growing body of evidence that many oxysterols...

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Published in: Biochemical and Biophysical Research Communications
ISSN: 0006291X
Published: 2018
Online Access: Check full text

URI: https://cronfa.swan.ac.uk/Record/cronfa38513
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Abstract: Oxysterols are oxidised derivatives of cholesterol or its precursors post lanosterol. They are intermediates in the biosynthesis of bile acids, steroid hormones and 1,25-dihydroxyvitamin D3. Although often considered as metabolic intermediates there is a growing body of evidence that many oxysterols are bioactive and their absence or excess may be part of the cause of a disease phenotype. Using global lipidomics approaches oxysterols are underrepresented encouraging the development of targeted approaches. In this article, we discuss recent discoveries important in oxysterol biochemistry and some of the targeted lipidomic approaches used to make these discoveries.
Keywords: Cancer, Cholesterol; Cytochrome P450, Hydroxysteroid dehydrogenase, Immunity, LC-MS, Sterol
College: Swansea University Medical School
Issue: 3
Start Page: 617
End Page: 622