Journal article 917 views 183 downloads
An update on oxysterol biochemistry: New discoveries in lipidomics
,
Yuqin Wang
Biochemical and Biophysical Research Communications, Volume: 504, Issue: 3, Pages: 617 - 622
Swansea University Author:
William Griffiths
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Open Access funded by Biotechnology and Biological Sciences Research Council under a Creative Commons license.
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DOI (Published version): 10.1016/j.bbrc.2018.02.019
Abstract
Oxysterols are oxidised derivatives of cholesterol or its precursors post lanosterol. They are intermediates in the biosynthesis of bile acids, steroid hormones and 1,25-dihydroxyvitamin D3. Although often considered as metabolic intermediates there is a growing body of evidence that many oxysterols...
| Published in: | Biochemical and Biophysical Research Communications |
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| ISSN: | 0006291X |
| Published: |
2018
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| Online Access: |
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| URI: | https://cronfa.swan.ac.uk/Record/cronfa38513 |
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| Abstract: |
Oxysterols are oxidised derivatives of cholesterol or its precursors post lanosterol. They are intermediates in the biosynthesis of bile acids, steroid hormones and 1,25-dihydroxyvitamin D3. Although often considered as metabolic intermediates there is a growing body of evidence that many oxysterols are bioactive and their absence or excess may be part of the cause of a disease phenotype. Using global lipidomics approaches oxysterols are underrepresented encouraging the development of targeted approaches. In this article, we discuss recent discoveries important in oxysterol biochemistry and some of the targeted lipidomic approaches used to make these discoveries. |
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| Keywords: |
Cancer, Cholesterol; Cytochrome P450, Hydroxysteroid dehydrogenase, Immunity, LC-MS, Sterol |
| College: |
Faculty of Medicine, Health and Life Sciences |
| Issue: |
3 |
| Start Page: |
617 |
| End Page: |
622 |