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An update on oxysterol biochemistry: New discoveries in lipidomics

William Griffiths Orcid Logo, Yuqin Wang

Biochemical and Biophysical Research Communications, Volume: 504, Issue: 3, Pages: 617 - 622

Swansea University Author: William Griffiths Orcid Logo

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DOI (Published version): 10.1016/j.bbrc.2018.02.019

Abstract

Oxysterols are oxidised derivatives of cholesterol or its precursors post lanosterol. They are intermediates in the biosynthesis of bile acids, steroid hormones and 1,25-dihydroxyvitamin D3. Although often considered as metabolic intermediates there is a growing body of evidence that many oxysterols...

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Published in: Biochemical and Biophysical Research Communications
ISSN: 0006291X
Published: 2018
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URI: https://cronfa.swan.ac.uk/Record/cronfa38513
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first_indexed 2018-02-12T20:26:26Z
last_indexed 2018-10-11T20:01:49Z
id cronfa38513
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spelling 2018-10-11T14:27:16.7142664 v2 38513 2018-02-12 An update on oxysterol biochemistry: New discoveries in lipidomics 3316b1d1b524be1831790933eed1c26e 0000-0002-4129-6616 William Griffiths William Griffiths true false 2018-02-12 BMS Oxysterols are oxidised derivatives of cholesterol or its precursors post lanosterol. They are intermediates in the biosynthesis of bile acids, steroid hormones and 1,25-dihydroxyvitamin D3. Although often considered as metabolic intermediates there is a growing body of evidence that many oxysterols are bioactive and their absence or excess may be part of the cause of a disease phenotype. Using global lipidomics approaches oxysterols are underrepresented encouraging the development of targeted approaches. In this article, we discuss recent discoveries important in oxysterol biochemistry and some of the targeted lipidomic approaches used to make these discoveries. Journal Article Biochemical and Biophysical Research Communications 504 3 617 622 0006291X Cancer, Cholesterol; Cytochrome P450, Hydroxysteroid dehydrogenase, Immunity, LC-MS, Sterol 7 10 2018 2018-10-07 10.1016/j.bbrc.2018.02.019 COLLEGE NANME Biomedical Sciences COLLEGE CODE BMS Swansea University 2018-10-11T14:27:16.7142664 2018-02-12T13:23:06.9828130 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medicine William Griffiths 0000-0002-4129-6616 1 Yuqin Wang 2 0038513-12022018132525.pdf Griffiths_BBRC_2018.pdf 2018-02-12T13:25:25.2800000 Output 512893 application/pdf Version of Record true 2018-02-12T00:00:00.0000000 Open Access funded by Biotechnology and Biological Sciences Research Council under a Creative Commons license. true eng
title An update on oxysterol biochemistry: New discoveries in lipidomics
spellingShingle An update on oxysterol biochemistry: New discoveries in lipidomics
William Griffiths
title_short An update on oxysterol biochemistry: New discoveries in lipidomics
title_full An update on oxysterol biochemistry: New discoveries in lipidomics
title_fullStr An update on oxysterol biochemistry: New discoveries in lipidomics
title_full_unstemmed An update on oxysterol biochemistry: New discoveries in lipidomics
title_sort An update on oxysterol biochemistry: New discoveries in lipidomics
author_id_str_mv 3316b1d1b524be1831790933eed1c26e
author_id_fullname_str_mv 3316b1d1b524be1831790933eed1c26e_***_William Griffiths
author William Griffiths
author2 William Griffiths
Yuqin Wang
format Journal article
container_title Biochemical and Biophysical Research Communications
container_volume 504
container_issue 3
container_start_page 617
publishDate 2018
institution Swansea University
issn 0006291X
doi_str_mv 10.1016/j.bbrc.2018.02.019
college_str Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str Swansea University Medical School - Medicine{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Medicine
document_store_str 1
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description Oxysterols are oxidised derivatives of cholesterol or its precursors post lanosterol. They are intermediates in the biosynthesis of bile acids, steroid hormones and 1,25-dihydroxyvitamin D3. Although often considered as metabolic intermediates there is a growing body of evidence that many oxysterols are bioactive and their absence or excess may be part of the cause of a disease phenotype. Using global lipidomics approaches oxysterols are underrepresented encouraging the development of targeted approaches. In this article, we discuss recent discoveries important in oxysterol biochemistry and some of the targeted lipidomic approaches used to make these discoveries.
published_date 2018-10-07T03:48:43Z
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score 11.016235

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