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PREVIEW (Prevention of Diabetes Through Lifestyle Intervention and Population Studies in Europe and Around the World) study in children aged 10 to 17 years: Design, methods and baseline results

Elke Dorenbos, Mathijs Drummen, Jesse Rijks, Tanja Adam, Pauline Stouthart, J. Alfredo Martínez, Santiago Navas-Carretero, Gareth Stratton Orcid Logo, Nils Swindell, Mikael Fogelholm, Anne Raben, Margriet Westerterp-Plantenga, Anita Vreugdenhil

Diabetes, Obesity and Metabolism, Volume: 20, Issue: 5, Pages: 1096 - 1101

Swansea University Author: Gareth Stratton Orcid Logo

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DOI (Published version): 10.1111/dom.13216

Abstract

Insulin resistance (IR) in adolescence is associated with type 2 diabetes mellitus [T2DM]. The PREVIEW (Prevention of Diabetes Through Lifestyle Intervention and Population Studies in Europe and Around the World) study assessed the effectiveness of a high-protein, low-glycaemic-index diet and a mode...

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Published in: Diabetes, Obesity and Metabolism
ISSN: 1462-8902
Published: 2018
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URI: https://cronfa.swan.ac.uk/Record/cronfa38781
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The PREVIEW (Prevention of Diabetes Through Lifestyle Intervention and Population Studies in Europe and Around the World) study assessed the effectiveness of a high-protein, low-glycaemic-index diet and a moderate-protein, moderate-glycaemic-index diet to decrease IR in insulin-resistant children who were overweight or obese. Inclusion criteria were age 10 to 17&#x2009;years, homeostatic model assessment of IR (HOMA-IR) &#x2265;2.0 and overweight/obesity. In 126 children (mean&#x2009;&#xB1;&#x2009;SD age 13.6 &#xB1; 2.2 years, body mass index [BMI] z-score 3.04&#x2009;&#xB1; 0.66, HOMA-IR 3.48&#x2009;&#xB1; 2.28) anthropometrics, fat mass percentage (FM%), metabolic characteristics, physical activity, food intake and sleep were measured. Baseline characteristics did not differ between the groups. IR was higher in pubertal children with morbid obesity than in prepubertal children with morbid obesity (5.41&#x2009;&#xB1; 1.86 vs 3.23&#x2009;&#xB1; 1.86; P =&#x2009;.007) and prepubertal and pubertal children with overweight/obesity (vs 3.61&#x2009;&#xB1; 1.60, P =&#x2009;.004, and vs 3.40&#x2009;&#xB1; 1.50, P &lt;&#x2009;.001, respectively). IR was associated with sex, Tanner stage, BMI z-score and FM%. Fasting glucose concentrations were negatively associated with Baecke sport score (r =&#x2009;&#x2212;0.223, P =&#x2009;.025) and positively with daytime sleepiness (r = 0.280, P =&#x2009;.016) independent of sex, Tanner stage, BMI z-score and FM%. In conclusion, IR was most severe in pubertal children with morbid obesity. 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spelling 2018-10-23T09:42:23.3785129 v2 38781 2018-02-19 PREVIEW (Prevention of Diabetes Through Lifestyle Intervention and Population Studies in Europe and Around the World) study in children aged 10 to 17 years: Design, methods and baseline results 6d62b2ed126961bed81a94a2beba8a01 0000-0001-5618-0803 Gareth Stratton Gareth Stratton true false 2018-02-19 EAAS Insulin resistance (IR) in adolescence is associated with type 2 diabetes mellitus [T2DM]. The PREVIEW (Prevention of Diabetes Through Lifestyle Intervention and Population Studies in Europe and Around the World) study assessed the effectiveness of a high-protein, low-glycaemic-index diet and a moderate-protein, moderate-glycaemic-index diet to decrease IR in insulin-resistant children who were overweight or obese. Inclusion criteria were age 10 to 17 years, homeostatic model assessment of IR (HOMA-IR) ≥2.0 and overweight/obesity. In 126 children (mean ± SD age 13.6 ± 2.2 years, body mass index [BMI] z-score 3.04 ± 0.66, HOMA-IR 3.48 ± 2.28) anthropometrics, fat mass percentage (FM%), metabolic characteristics, physical activity, food intake and sleep were measured. Baseline characteristics did not differ between the groups. IR was higher in pubertal children with morbid obesity than in prepubertal children with morbid obesity (5.41 ± 1.86 vs 3.23 ± 1.86; P = .007) and prepubertal and pubertal children with overweight/obesity (vs 3.61 ± 1.60, P = .004, and vs 3.40 ± 1.50, P < .001, respectively). IR was associated with sex, Tanner stage, BMI z-score and FM%. Fasting glucose concentrations were negatively associated with Baecke sport score (r = −0.223, P = .025) and positively with daytime sleepiness (r = 0.280, P = .016) independent of sex, Tanner stage, BMI z-score and FM%. In conclusion, IR was most severe in pubertal children with morbid obesity. The associations between fasting glucose concentration and Baecke sport score and sleepiness suggest these might be possible targets for diabetes prevention. Journal Article Diabetes, Obesity and Metabolism 20 5 1096 1101 1462-8902 dietary intervention; insulin resistance; randomized trial; type 2 diabetes 31 12 2018 2018-12-31 10.1111/dom.13216 COLLEGE NANME Engineering and Applied Sciences School COLLEGE CODE EAAS Swansea University 2018-10-23T09:42:23.3785129 2018-02-19T12:42:17.2001554 Faculty of Science and Engineering School of Aerospace, Civil, Electrical, General and Mechanical Engineering - Sport and Exercise Sciences Elke Dorenbos 1 Mathijs Drummen 2 Jesse Rijks 3 Tanja Adam 4 Pauline Stouthart 5 J. Alfredo Martínez 6 Santiago Navas-Carretero 7 Gareth Stratton 0000-0001-5618-0803 8 Nils Swindell 9 Mikael Fogelholm 10 Anne Raben 11 Margriet Westerterp-Plantenga 12 Anita Vreugdenhil 13 0038781-20022018105704.pdf dorenbos2018.pdf 2018-02-20T10:57:04.1430000 Output 656989 application/pdf Accepted Manuscript true 2019-02-08T00:00:00.0000000 true eng 0038781-20022018105748.pdf dorenbos2018SI.pdf 2018-02-20T10:57:48.9470000 Output 759056 application/pdf Accepted Manuscript true 2019-02-08T00:00:00.0000000 Supplementary data true eng
title PREVIEW (Prevention of Diabetes Through Lifestyle Intervention and Population Studies in Europe and Around the World) study in children aged 10 to 17 years: Design, methods and baseline results
spellingShingle PREVIEW (Prevention of Diabetes Through Lifestyle Intervention and Population Studies in Europe and Around the World) study in children aged 10 to 17 years: Design, methods and baseline results
Gareth Stratton
title_short PREVIEW (Prevention of Diabetes Through Lifestyle Intervention and Population Studies in Europe and Around the World) study in children aged 10 to 17 years: Design, methods and baseline results
title_full PREVIEW (Prevention of Diabetes Through Lifestyle Intervention and Population Studies in Europe and Around the World) study in children aged 10 to 17 years: Design, methods and baseline results
title_fullStr PREVIEW (Prevention of Diabetes Through Lifestyle Intervention and Population Studies in Europe and Around the World) study in children aged 10 to 17 years: Design, methods and baseline results
title_full_unstemmed PREVIEW (Prevention of Diabetes Through Lifestyle Intervention and Population Studies in Europe and Around the World) study in children aged 10 to 17 years: Design, methods and baseline results
title_sort PREVIEW (Prevention of Diabetes Through Lifestyle Intervention and Population Studies in Europe and Around the World) study in children aged 10 to 17 years: Design, methods and baseline results
author_id_str_mv 6d62b2ed126961bed81a94a2beba8a01
author_id_fullname_str_mv 6d62b2ed126961bed81a94a2beba8a01_***_Gareth Stratton
author Gareth Stratton
author2 Elke Dorenbos
Mathijs Drummen
Jesse Rijks
Tanja Adam
Pauline Stouthart
J. Alfredo Martínez
Santiago Navas-Carretero
Gareth Stratton
Nils Swindell
Mikael Fogelholm
Anne Raben
Margriet Westerterp-Plantenga
Anita Vreugdenhil
format Journal article
container_title Diabetes, Obesity and Metabolism
container_volume 20
container_issue 5
container_start_page 1096
publishDate 2018
institution Swansea University
issn 1462-8902
doi_str_mv 10.1111/dom.13216
college_str Faculty of Science and Engineering
hierarchytype
hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Aerospace, Civil, Electrical, General and Mechanical Engineering - Sport and Exercise Sciences{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Aerospace, Civil, Electrical, General and Mechanical Engineering - Sport and Exercise Sciences
document_store_str 1
active_str 0
description Insulin resistance (IR) in adolescence is associated with type 2 diabetes mellitus [T2DM]. The PREVIEW (Prevention of Diabetes Through Lifestyle Intervention and Population Studies in Europe and Around the World) study assessed the effectiveness of a high-protein, low-glycaemic-index diet and a moderate-protein, moderate-glycaemic-index diet to decrease IR in insulin-resistant children who were overweight or obese. Inclusion criteria were age 10 to 17 years, homeostatic model assessment of IR (HOMA-IR) ≥2.0 and overweight/obesity. In 126 children (mean ± SD age 13.6 ± 2.2 years, body mass index [BMI] z-score 3.04 ± 0.66, HOMA-IR 3.48 ± 2.28) anthropometrics, fat mass percentage (FM%), metabolic characteristics, physical activity, food intake and sleep were measured. Baseline characteristics did not differ between the groups. IR was higher in pubertal children with morbid obesity than in prepubertal children with morbid obesity (5.41 ± 1.86 vs 3.23 ± 1.86; P = .007) and prepubertal and pubertal children with overweight/obesity (vs 3.61 ± 1.60, P = .004, and vs 3.40 ± 1.50, P < .001, respectively). IR was associated with sex, Tanner stage, BMI z-score and FM%. Fasting glucose concentrations were negatively associated with Baecke sport score (r = −0.223, P = .025) and positively with daytime sleepiness (r = 0.280, P = .016) independent of sex, Tanner stage, BMI z-score and FM%. In conclusion, IR was most severe in pubertal children with morbid obesity. The associations between fasting glucose concentration and Baecke sport score and sleepiness suggest these might be possible targets for diabetes prevention.
published_date 2018-12-31T04:22:27Z
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