No Cover Image

Journal article 165 views 74 downloads

The PREVIEW intervention study: Results from a 3‐year randomized 2 x 2 factorial multinational trial investigating the role of protein, glycaemic index and physical activity for prevention of type 2 diabetes / Anne Raben, Pia Siig Vestentoft, Jennie Brand‐Miller, Elli Jalo, Mathjis Drummen, Liz Simpson, J. Alfredo Martinez, Teodora Handjieva‐Darlenska, Gareth Stratton, Maija Huttunen‐Lenz, Tony Lam, Jouko Sundvall, Roslyn Muirhead, Sally Poppitt, Christian Ritz, Kirsi H. Pietiläinen, Margriet Westerterp‐Plantenga, Moira A. Taylor, Santiago Navas‐Carretero, Svetoslav Handjiev, Melitta McNarry, Sylvia Hansen, Laura Råman, Shannon Brodie, Marta P. Silvestre, Tanja C. Adam, Ian A. Macdonald, Rodrigo San‐Cristobal, Nadka Boyadjieva, Kelly Mackintosh, Wolfgang Schlicht, Amy Liu, Thomas M. Larsen, Mikael Fogelholm

Diabetes, Obesity and Metabolism, Volume: 23, Issue: 2, Pages: 324 - 337

Swansea University Authors: Gareth Stratton, Melitta McNarry, Kelly Mackintosh

Check full text

DOI (Published version): 10.1111/dom.14219

Abstract

AimTo compare the impact of 2 long‐term weight‐maintenance diets: High‐protein (HP), low‐glycaemic index (GI) and moderate‐protein (MP), moderate‐GI, combined with high‐intensity (HI) or moderate‐intensity (MI) physical activity (PA) on incidence of type‐2 diabetes (T2D) after rapid weight loss.Mate...

Full description

Published in: Diabetes, Obesity and Metabolism
ISSN: 1462-8902 1463-1326
Published: Wiley 2021
Online Access: Check full text

URI: https://cronfa.swan.ac.uk/Record/cronfa55357
Tags: Add Tag
No Tags, Be the first to tag this record!
Abstract: AimTo compare the impact of 2 long‐term weight‐maintenance diets: High‐protein (HP), low‐glycaemic index (GI) and moderate‐protein (MP), moderate‐GI, combined with high‐intensity (HI) or moderate‐intensity (MI) physical activity (PA) on incidence of type‐2 diabetes (T2D) after rapid weight loss.Materials and methodsA 3‐year multicentre randomised trial in 8 countries using a 2x2 diet‐by‐PA factorial design. 8‐weeks weight‐reduction was followed by a 3‐year randomised weight‐maintenance phase. 2,326 adults (25‐70 y, BMI≥25 kg/m2) with pre‐diabetes were enrolled. Primary endpoint was 3‐year incidence of T2D analysed by diet treatment. Secondary outcomes included glucose, insulin, HbA1C, and body weight.ResultsTotal number of T2D cases was 62 and cumulative incidence rate 3.1%, with no significant differences between the 2 diets, PA, or their combination. T2D incidence was similar across intervention centres, irrespective of attrition. Signficantly fewer achieved normo‐glycemia in the HP compared with the MP group (p<0.0001). At 3‐years, normoglycemia was lowest in HP‐HI (11.9%) compared with the other 3 groups (20.0‐21.0%, p<0.05). There were no group differences in body weight change (‐11% after 8‐weeks weight reduction; ‐5% after 3 years weight maintenance) or in other secondary outcomes.ConclusionsThree‐year incidence of T2D was much lower than predicted and did not differ between diets, PA or their combination. Maintaining the target intakes of protein and GI over 3 years was difficult, but the overall protocol combining weight loss, healthy eating, and physical activity was successful in markedly reducing the risk of T2D. This is an important clinically relevant outcome.
Keywords: behaviour change; carbohydrate; dietary intervention; exercise intervention; glycaemic control; obesity
College: College of Engineering
Issue: 2
Start Page: 324
End Page: 337