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The PREVIEW intervention study: Results from a 3‐year randomized 2 x 2 factorial multinational trial investigating the role of protein, glycaemic index and physical activity for prevention of type 2 diabetes

Anne Raben, Pia Siig Vestentoft, Jennie Brand‐Miller, Elli Jalo, Mathjis Drummen, Liz Simpson, J. Alfredo Martinez, Teodora Handjieva‐Darlenska, Gareth Stratton Orcid Logo, Maija Huttunen‐Lenz, Tony Lam, Jouko Sundvall, Roslyn Muirhead, Sally Poppitt, Christian Ritz, Kirsi H. Pietiläinen, Margriet Westerterp‐Plantenga, Moira A. Taylor, Santiago Navas‐Carretero, Svetoslav Handjiev, Melitta McNarry Orcid Logo, Sylvia Hansen, Laura Råman, Shannon Brodie, Marta P. Silvestre, Tanja C. Adam, Ian A. Macdonald, Rodrigo San‐Cristobal, Nadka Boyadjieva, Kelly Mackintosh Orcid Logo, Wolfgang Schlicht, Amy Liu, Thomas M. Larsen, Mikael Fogelholm

Diabetes, Obesity and Metabolism, Volume: 23, Issue: 2, Pages: 324 - 337

Swansea University Authors: Gareth Stratton Orcid Logo, Melitta McNarry Orcid Logo, Kelly Mackintosh Orcid Logo

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DOI (Published version): 10.1111/dom.14219

Abstract

AimTo compare the impact of 2 long‐term weight‐maintenance diets: High‐protein (HP), low‐glycaemic index (GI) and moderate‐protein (MP), moderate‐GI, combined with high‐intensity (HI) or moderate‐intensity (MI) physical activity (PA) on incidence of type‐2 diabetes (T2D) after rapid weight loss.Mate...

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Published in: Diabetes, Obesity and Metabolism
ISSN: 1462-8902 1463-1326
Published: Wiley 2021
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URI: https://cronfa.swan.ac.uk/Record/cronfa55357
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fullrecord <?xml version="1.0"?><rfc1807><datestamp>2021-12-01T11:57:53.8249237</datestamp><bib-version>v2</bib-version><id>55357</id><entry>2020-10-07</entry><title>The PREVIEW intervention study: Results from a 3&#x2010;year randomized 2 x 2 factorial multinational trial investigating the role of protein, glycaemic index and physical activity for prevention of type 2 diabetes</title><swanseaauthors><author><sid>6d62b2ed126961bed81a94a2beba8a01</sid><ORCID>0000-0001-5618-0803</ORCID><firstname>Gareth</firstname><surname>Stratton</surname><name>Gareth Stratton</name><active>true</active><ethesisStudent>false</ethesisStudent></author><author><sid>062f5697ff59f004bc8c713955988398</sid><ORCID>0000-0003-0813-7477</ORCID><firstname>Melitta</firstname><surname>McNarry</surname><name>Melitta McNarry</name><active>true</active><ethesisStudent>false</ethesisStudent></author><author><sid>bdb20e3f31bcccf95c7bc116070c4214</sid><ORCID>0000-0003-0355-6357</ORCID><firstname>Kelly</firstname><surname>Mackintosh</surname><name>Kelly Mackintosh</name><active>true</active><ethesisStudent>false</ethesisStudent></author></swanseaauthors><date>2020-10-07</date><deptcode>STSC</deptcode><abstract>AimTo compare the impact of 2 long&#x2010;term weight&#x2010;maintenance diets: High&#x2010;protein (HP), low&#x2010;glycaemic index (GI) and moderate&#x2010;protein (MP), moderate&#x2010;GI, combined with high&#x2010;intensity (HI) or moderate&#x2010;intensity (MI) physical activity (PA) on incidence of type&#x2010;2 diabetes (T2D) after rapid weight loss.Materials and methodsA 3&#x2010;year multicentre randomised trial in 8 countries using a 2x2 diet&#x2010;by&#x2010;PA factorial design. 8&#x2010;weeks weight&#x2010;reduction was followed by a 3&#x2010;year randomised weight&#x2010;maintenance phase. 2,326 adults (25&#x2010;70 y, BMI&#x2265;25 kg/m2) with pre&#x2010;diabetes were enrolled. Primary endpoint was 3&#x2010;year incidence of T2D analysed by diet treatment. Secondary outcomes included glucose, insulin, HbA1C, and body weight.ResultsTotal number of T2D cases was 62 and cumulative incidence rate 3.1%, with no significant differences between the 2 diets, PA, or their combination. T2D incidence was similar across intervention centres, irrespective of attrition. Signficantly fewer achieved normo&#x2010;glycemia in the HP compared with the MP group (p&lt;0.0001). At 3&#x2010;years, normoglycemia was lowest in HP&#x2010;HI (11.9%) compared with the other 3 groups (20.0&#x2010;21.0%, p&lt;0.05). There were no group differences in body weight change (&#x2010;11% after 8&#x2010;weeks weight reduction; &#x2010;5% after 3&#x2009;years weight maintenance) or in other secondary outcomes.ConclusionsThree&#x2010;year incidence of T2D was much lower than predicted and did not differ between diets, PA or their combination. Maintaining the target intakes of protein and GI over 3&#x2009;years was difficult, but the overall protocol combining weight loss, healthy eating, and physical activity was successful in markedly reducing the risk of T2D. This is an important clinically relevant outcome.</abstract><type>Journal Article</type><journal>Diabetes, Obesity and Metabolism</journal><volume>23</volume><journalNumber>2</journalNumber><paginationStart>324</paginationStart><paginationEnd>337</paginationEnd><publisher>Wiley</publisher><placeOfPublication/><isbnPrint/><isbnElectronic/><issnPrint>1462-8902</issnPrint><issnElectronic>1463-1326</issnElectronic><keywords>behaviour change; carbohydrate; dietary intervention; exercise intervention; glycaemic control; obesity</keywords><publishedDay>1</publishedDay><publishedMonth>2</publishedMonth><publishedYear>2021</publishedYear><publishedDate>2021-02-01</publishedDate><doi>10.1111/dom.14219</doi><url/><notes/><college>COLLEGE NANME</college><department>Sport and Exercise Sciences</department><CollegeCode>COLLEGE CODE</CollegeCode><DepartmentCode>STSC</DepartmentCode><institution>Swansea University</institution><apcterm/><lastEdited>2021-12-01T11:57:53.8249237</lastEdited><Created>2020-10-07T08:54:20.2091337</Created><path><level id="1">Faculty of Science and Engineering</level><level id="2">School of Aerospace, Civil, Electrical, General and Mechanical Engineering - Sport and Exercise Sciences</level></path><authors><author><firstname>Anne</firstname><surname>Raben</surname><order>1</order></author><author><firstname>Pia Siig</firstname><surname>Vestentoft</surname><order>2</order></author><author><firstname>Jennie</firstname><surname>Brand&#x2010;Miller</surname><order>3</order></author><author><firstname>Elli</firstname><surname>Jalo</surname><order>4</order></author><author><firstname>Mathjis</firstname><surname>Drummen</surname><order>5</order></author><author><firstname>Liz</firstname><surname>Simpson</surname><order>6</order></author><author><firstname>J. Alfredo</firstname><surname>Martinez</surname><order>7</order></author><author><firstname>Teodora</firstname><surname>Handjieva&#x2010;Darlenska</surname><order>8</order></author><author><firstname>Gareth</firstname><surname>Stratton</surname><orcid>0000-0001-5618-0803</orcid><order>9</order></author><author><firstname>Maija</firstname><surname>Huttunen&#x2010;Lenz</surname><order>10</order></author><author><firstname>Tony</firstname><surname>Lam</surname><order>11</order></author><author><firstname>Jouko</firstname><surname>Sundvall</surname><order>12</order></author><author><firstname>Roslyn</firstname><surname>Muirhead</surname><order>13</order></author><author><firstname>Sally</firstname><surname>Poppitt</surname><order>14</order></author><author><firstname>Christian</firstname><surname>Ritz</surname><order>15</order></author><author><firstname>Kirsi H.</firstname><surname>Pietil&#xE4;inen</surname><order>16</order></author><author><firstname>Margriet</firstname><surname>Westerterp&#x2010;Plantenga</surname><order>17</order></author><author><firstname>Moira A.</firstname><surname>Taylor</surname><order>18</order></author><author><firstname>Santiago</firstname><surname>Navas&#x2010;Carretero</surname><order>19</order></author><author><firstname>Svetoslav</firstname><surname>Handjiev</surname><order>20</order></author><author><firstname>Melitta</firstname><surname>McNarry</surname><orcid>0000-0003-0813-7477</orcid><order>21</order></author><author><firstname>Sylvia</firstname><surname>Hansen</surname><order>22</order></author><author><firstname>Laura</firstname><surname>R&#xE5;man</surname><order>23</order></author><author><firstname>Shannon</firstname><surname>Brodie</surname><order>24</order></author><author><firstname>Marta P.</firstname><surname>Silvestre</surname><order>25</order></author><author><firstname>Tanja C.</firstname><surname>Adam</surname><order>26</order></author><author><firstname>Ian A.</firstname><surname>Macdonald</surname><order>27</order></author><author><firstname>Rodrigo</firstname><surname>San&#x2010;Cristobal</surname><order>28</order></author><author><firstname>Nadka</firstname><surname>Boyadjieva</surname><order>29</order></author><author><firstname>Kelly</firstname><surname>Mackintosh</surname><orcid>0000-0003-0355-6357</orcid><order>30</order></author><author><firstname>Wolfgang</firstname><surname>Schlicht</surname><order>31</order></author><author><firstname>Amy</firstname><surname>Liu</surname><order>32</order></author><author><firstname>Thomas M.</firstname><surname>Larsen</surname><order>33</order></author><author><firstname>Mikael</firstname><surname>Fogelholm</surname><order>34</order></author></authors><documents><document><filename>55357__19030__2bbf34df7331454a91a2476c2bdb611a.pdf</filename><originalFilename>55357 (2).pdf</originalFilename><uploaded>2021-01-12T09:15:14.5634275</uploaded><type>Output</type><contentLength>2783263</contentLength><contentType>application/pdf</contentType><version>Version of Record</version><cronfaStatus>true</cronfaStatus><copyrightCorrect>false</copyrightCorrect><language>eng</language><licence>https://creativecommons.org/licenses/by-nc-nd/4.0/</licence></document></documents><OutputDurs/></rfc1807>
spelling 2021-12-01T11:57:53.8249237 v2 55357 2020-10-07 The PREVIEW intervention study: Results from a 3‐year randomized 2 x 2 factorial multinational trial investigating the role of protein, glycaemic index and physical activity for prevention of type 2 diabetes 6d62b2ed126961bed81a94a2beba8a01 0000-0001-5618-0803 Gareth Stratton Gareth Stratton true false 062f5697ff59f004bc8c713955988398 0000-0003-0813-7477 Melitta McNarry Melitta McNarry true false bdb20e3f31bcccf95c7bc116070c4214 0000-0003-0355-6357 Kelly Mackintosh Kelly Mackintosh true false 2020-10-07 STSC AimTo compare the impact of 2 long‐term weight‐maintenance diets: High‐protein (HP), low‐glycaemic index (GI) and moderate‐protein (MP), moderate‐GI, combined with high‐intensity (HI) or moderate‐intensity (MI) physical activity (PA) on incidence of type‐2 diabetes (T2D) after rapid weight loss.Materials and methodsA 3‐year multicentre randomised trial in 8 countries using a 2x2 diet‐by‐PA factorial design. 8‐weeks weight‐reduction was followed by a 3‐year randomised weight‐maintenance phase. 2,326 adults (25‐70 y, BMI≥25 kg/m2) with pre‐diabetes were enrolled. Primary endpoint was 3‐year incidence of T2D analysed by diet treatment. Secondary outcomes included glucose, insulin, HbA1C, and body weight.ResultsTotal number of T2D cases was 62 and cumulative incidence rate 3.1%, with no significant differences between the 2 diets, PA, or their combination. T2D incidence was similar across intervention centres, irrespective of attrition. Signficantly fewer achieved normo‐glycemia in the HP compared with the MP group (p<0.0001). At 3‐years, normoglycemia was lowest in HP‐HI (11.9%) compared with the other 3 groups (20.0‐21.0%, p<0.05). There were no group differences in body weight change (‐11% after 8‐weeks weight reduction; ‐5% after 3 years weight maintenance) or in other secondary outcomes.ConclusionsThree‐year incidence of T2D was much lower than predicted and did not differ between diets, PA or their combination. Maintaining the target intakes of protein and GI over 3 years was difficult, but the overall protocol combining weight loss, healthy eating, and physical activity was successful in markedly reducing the risk of T2D. This is an important clinically relevant outcome. Journal Article Diabetes, Obesity and Metabolism 23 2 324 337 Wiley 1462-8902 1463-1326 behaviour change; carbohydrate; dietary intervention; exercise intervention; glycaemic control; obesity 1 2 2021 2021-02-01 10.1111/dom.14219 COLLEGE NANME Sport and Exercise Sciences COLLEGE CODE STSC Swansea University 2021-12-01T11:57:53.8249237 2020-10-07T08:54:20.2091337 Faculty of Science and Engineering School of Aerospace, Civil, Electrical, General and Mechanical Engineering - Sport and Exercise Sciences Anne Raben 1 Pia Siig Vestentoft 2 Jennie Brand‐Miller 3 Elli Jalo 4 Mathjis Drummen 5 Liz Simpson 6 J. Alfredo Martinez 7 Teodora Handjieva‐Darlenska 8 Gareth Stratton 0000-0001-5618-0803 9 Maija Huttunen‐Lenz 10 Tony Lam 11 Jouko Sundvall 12 Roslyn Muirhead 13 Sally Poppitt 14 Christian Ritz 15 Kirsi H. Pietiläinen 16 Margriet Westerterp‐Plantenga 17 Moira A. Taylor 18 Santiago Navas‐Carretero 19 Svetoslav Handjiev 20 Melitta McNarry 0000-0003-0813-7477 21 Sylvia Hansen 22 Laura Råman 23 Shannon Brodie 24 Marta P. Silvestre 25 Tanja C. Adam 26 Ian A. Macdonald 27 Rodrigo San‐Cristobal 28 Nadka Boyadjieva 29 Kelly Mackintosh 0000-0003-0355-6357 30 Wolfgang Schlicht 31 Amy Liu 32 Thomas M. Larsen 33 Mikael Fogelholm 34 55357__19030__2bbf34df7331454a91a2476c2bdb611a.pdf 55357 (2).pdf 2021-01-12T09:15:14.5634275 Output 2783263 application/pdf Version of Record true false eng https://creativecommons.org/licenses/by-nc-nd/4.0/
title The PREVIEW intervention study: Results from a 3‐year randomized 2 x 2 factorial multinational trial investigating the role of protein, glycaemic index and physical activity for prevention of type 2 diabetes
spellingShingle The PREVIEW intervention study: Results from a 3‐year randomized 2 x 2 factorial multinational trial investigating the role of protein, glycaemic index and physical activity for prevention of type 2 diabetes
Gareth Stratton
Melitta McNarry
Kelly Mackintosh
title_short The PREVIEW intervention study: Results from a 3‐year randomized 2 x 2 factorial multinational trial investigating the role of protein, glycaemic index and physical activity for prevention of type 2 diabetes
title_full The PREVIEW intervention study: Results from a 3‐year randomized 2 x 2 factorial multinational trial investigating the role of protein, glycaemic index and physical activity for prevention of type 2 diabetes
title_fullStr The PREVIEW intervention study: Results from a 3‐year randomized 2 x 2 factorial multinational trial investigating the role of protein, glycaemic index and physical activity for prevention of type 2 diabetes
title_full_unstemmed The PREVIEW intervention study: Results from a 3‐year randomized 2 x 2 factorial multinational trial investigating the role of protein, glycaemic index and physical activity for prevention of type 2 diabetes
title_sort The PREVIEW intervention study: Results from a 3‐year randomized 2 x 2 factorial multinational trial investigating the role of protein, glycaemic index and physical activity for prevention of type 2 diabetes
author_id_str_mv 6d62b2ed126961bed81a94a2beba8a01
062f5697ff59f004bc8c713955988398
bdb20e3f31bcccf95c7bc116070c4214
author_id_fullname_str_mv 6d62b2ed126961bed81a94a2beba8a01_***_Gareth Stratton
062f5697ff59f004bc8c713955988398_***_Melitta McNarry
bdb20e3f31bcccf95c7bc116070c4214_***_Kelly Mackintosh
author Gareth Stratton
Melitta McNarry
Kelly Mackintosh
author2 Anne Raben
Pia Siig Vestentoft
Jennie Brand‐Miller
Elli Jalo
Mathjis Drummen
Liz Simpson
J. Alfredo Martinez
Teodora Handjieva‐Darlenska
Gareth Stratton
Maija Huttunen‐Lenz
Tony Lam
Jouko Sundvall
Roslyn Muirhead
Sally Poppitt
Christian Ritz
Kirsi H. Pietiläinen
Margriet Westerterp‐Plantenga
Moira A. Taylor
Santiago Navas‐Carretero
Svetoslav Handjiev
Melitta McNarry
Sylvia Hansen
Laura Råman
Shannon Brodie
Marta P. Silvestre
Tanja C. Adam
Ian A. Macdonald
Rodrigo San‐Cristobal
Nadka Boyadjieva
Kelly Mackintosh
Wolfgang Schlicht
Amy Liu
Thomas M. Larsen
Mikael Fogelholm
format Journal article
container_title Diabetes, Obesity and Metabolism
container_volume 23
container_issue 2
container_start_page 324
publishDate 2021
institution Swansea University
issn 1462-8902
1463-1326
doi_str_mv 10.1111/dom.14219
publisher Wiley
college_str Faculty of Science and Engineering
hierarchytype
hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Aerospace, Civil, Electrical, General and Mechanical Engineering - Sport and Exercise Sciences{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Aerospace, Civil, Electrical, General and Mechanical Engineering - Sport and Exercise Sciences
document_store_str 1
active_str 0
description AimTo compare the impact of 2 long‐term weight‐maintenance diets: High‐protein (HP), low‐glycaemic index (GI) and moderate‐protein (MP), moderate‐GI, combined with high‐intensity (HI) or moderate‐intensity (MI) physical activity (PA) on incidence of type‐2 diabetes (T2D) after rapid weight loss.Materials and methodsA 3‐year multicentre randomised trial in 8 countries using a 2x2 diet‐by‐PA factorial design. 8‐weeks weight‐reduction was followed by a 3‐year randomised weight‐maintenance phase. 2,326 adults (25‐70 y, BMI≥25 kg/m2) with pre‐diabetes were enrolled. Primary endpoint was 3‐year incidence of T2D analysed by diet treatment. Secondary outcomes included glucose, insulin, HbA1C, and body weight.ResultsTotal number of T2D cases was 62 and cumulative incidence rate 3.1%, with no significant differences between the 2 diets, PA, or their combination. T2D incidence was similar across intervention centres, irrespective of attrition. Signficantly fewer achieved normo‐glycemia in the HP compared with the MP group (p<0.0001). At 3‐years, normoglycemia was lowest in HP‐HI (11.9%) compared with the other 3 groups (20.0‐21.0%, p<0.05). There were no group differences in body weight change (‐11% after 8‐weeks weight reduction; ‐5% after 3 years weight maintenance) or in other secondary outcomes.ConclusionsThree‐year incidence of T2D was much lower than predicted and did not differ between diets, PA or their combination. Maintaining the target intakes of protein and GI over 3 years was difficult, but the overall protocol combining weight loss, healthy eating, and physical activity was successful in markedly reducing the risk of T2D. This is an important clinically relevant outcome.
published_date 2021-02-01T04:09:30Z
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score 10.99807

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