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Associations of quantity and quality of carbohydrate sources with subjective appetite sensations during 3-year weight-loss maintenance: Results from the PREVIEW intervention study

Ruixin Zhu, Thomas M. Larsen, Sally D. Poppitt, Marta P. Silvestre, Mikael Fogelholm, Elli Jalo, Katja A. Hätönen, Maija Huttunen-Lenz, Moira A. Taylor, Liz Simpson, Kelly Mackintosh Orcid Logo, Melitta McNarry Orcid Logo, Santiago Navas-Carretero, J. Alfredo Martinez, Teodora Handjieva-Darlenska, Svetoslav Handjiev, Mathijs Drummen, Margriet S. Westerterp-Plantenga, Tony Lam, Pia S. Vestentoft, Roslyn Muirhead, Jennie Brand-Miller, Anne Raben

Clinical Nutrition, Volume: 41, Issue: 1, Pages: 219 - 230

Swansea University Authors: Kelly Mackintosh Orcid Logo, Melitta McNarry Orcid Logo

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Abstract

The association of quantity and quality of carbohydrate sources with appetite during long-term weight-loss maintenance (WLM) after intentional weight loss (WL) is unclear. We aimed to investigate longitudinal associations of quantity and quality of carbohydrate sources with changes in subjective app...

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Published in: Clinical Nutrition
ISSN: 0261-5614 1532-1983
Published: Elsevier BV 2022
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URI: https://cronfa.swan.ac.uk/Record/cronfa59075
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Abstract: The association of quantity and quality of carbohydrate sources with appetite during long-term weight-loss maintenance (WLM) after intentional weight loss (WL) is unclear. We aimed to investigate longitudinal associations of quantity and quality of carbohydrate sources with changes in subjective appetite sensations during WLM. This secondary analysis evaluated longitudinal data from the 3-year WLM phase of the PREVIEW study, a 2 × 2 factorial (diet-physical activity arms), multi-center, randomized trial. 1279 individuals with overweight or obesity and prediabetes (25-70 years; BMI≥25 kg m ) were included. Individuals were merged into 1 group to assess longitudinal associations of yearly changes in appetite sensations. Quantity and quality of carbohydrate sources including total carbohydrate, glycemic index (GI), glycemic load (GL), and total dietary fiber were assessed via 4-day food diaries at 4 timepoints (26, 52, 104, and 156 weeks) during WLM. Visual analog scales were used to assess appetite sensations in the previous week. During WLM, participants consumed on average 160.6 (25th, 75th percentiles 131.1, 195.8) g·day of total carbohydrate, with GI 53.8 (48.7, 58.8) and GL 85.3 (67.2, 108.9) g day , and 22.3 (17.6, 27.3) g·day of dietary fiber. In the available-case analysis, multivariable-adjusted linear mixed models with repeated measures showed that each 30-g increment in total carbohydrate was associated with increases in hunger (1.36 mm year , 95% CI 0.77, 1.95, P < 0.001), desire to eat (1.10 mm year , 0.59, 1.60, P < 0.001), desire to eat something sweet (0.99 mm year , 0.30, 1.68, P = 0.005), and weight regain (0.20%·year , 0.03, 0.36, P = 0.022). Increasing GI was associated with weight regain, but not associated with increases in appetite sensations. Each 20-unit increment in GL was associated with increases in hunger (0.92 mm year , 0.33, 1.51, P = 0.002), desire to eat (1.12 mm year , 0.62, 1.62, P < 0.001), desire to eat something sweet (1.13 mm year , 0.44, 1.81, P < 0.001), and weight regain (0.35%·year , 0.18, 0.52, P < 0.001). Surprisingly, dietary fiber was also associated with increases in desire to eat, after adjustment for carbohydrate or GL. In participants with moderate carbohydrate and dietary fiber intake, and low to moderate GI, we found that higher total carbohydrate, GL, and total fiber, but not GI, were associated with increases in subjective desire to eat or hunger over 3 years. This study was registered as ClinicalTrials.gov, NCT01777893. [Abstract copyright: Copyright © 2021 The Author(s). Published by Elsevier Ltd.. All rights reserved.]
Keywords: Glycemic index; Glycemic load; Dietary fiber; Satiety; Hunger; Desire to eat
College: College of Engineering
Funders: The Sources of Support including grants, fellowships, and gifts of materials: EU framework programme 7 ( FP7 /2007–2013 ) grant agreement # 312,057. National Health and Medical Research Council - EU Collaborative Grant, AUS 8, ID 1067711 ). The Glycemic Index Foundation Australia through royalties to the University of Sydney. The New Zealand Health Research Council (grant #14/191 ) and University of Auckland Faculty Research Development Fund. The Cambridge Weight Plan© donated all products for the 8-weeks LED period. The Danish Agriculture & Food Council. The Danish Meat and Research Institute. National Institute for Health Research Biomedical Research Centre (NIHR BRC) (UK). Engineering and Physical Sciences Research Council (EPSRC) (UK). Nutritics (Dublin) donated all dietary analyses software used by UNOTT. Juho Vainio Foundation (FIN), Academy of Finland (grant numbers: 272376 , 314383 , 266286 , 314135 ), Finnish Medical Foundation, Gyllenberg Foundation, Novo Nordisk Foundation, Finnish Diabetes Research Foundation, University of Helsinki, Government Research Funds for Helsinki University Hospital (FIN), Jenny and Antti Wihuri Foundation (FIN), Emil Aaltonen Foundation (FIN). China Scholarship Council.
Issue: 1
Start Page: 219
End Page: 230