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A generalised porous medium approach to study thermo-fluid dynamics in human eyes / Alessandro Mauro; Nicola Massarotti; Mohamed Salahudeen; Mario R. Romano; Vito Romano; Perumal Nithiarasu

Medical & Biological Engineering & Computing

Swansea University Author: Nithiarasu, Perumal

Abstract

The present work describes the application of the generalised porous medium model to study heat and fluid flow in healthy and glaucomatous eyes of different subject specimens, considering the presence of ocular cavities and porous tissues. The 2D computational model, implemented into the open-source...

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Published in: Medical & Biological Engineering & Computing
ISSN: 0140-0118 1741-0444
Published: 2018
Online Access: Check full text

URI: https://cronfa.swan.ac.uk/Record/cronfa38914
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Abstract: The present work describes the application of the generalised porous medium model to study heat and fluid flow in healthy and glaucomatous eyes of different subject specimens, considering the presence of ocular cavities and porous tissues. The 2D computational model, implemented into the open-source software OpenFOAM, has been verified against benchmark data for mixed convection in domains partially filled with a porous medium. The verified model has been employed to simulate the thermo-fluid dynamic phenomena occurring in the anterior section of four patient-specific human eyes, considering the presence of anterior chamber (AC), trabecular meshwork (TM), Schlemm’s canal (SC), and collector channels (CC). The computational domains of the eye are extracted from tomographic images. The dependence of TM porosity and permeability on intraocular pressure (IOP) has been analysed in detail, and the differences between healthy and glaucomatous eye conditions have been highlighted, proving that the different physiological conditions of patients have a significant influence on the thermo-fluid dynamic phenomena. The influence of different eye positions (supine and standing) on thermo-fluid dynamic variables has been also investigated: results are presented in terms of velocity, pressure, temperature, friction coefficient and local Nusselt number. The results clearly indicate that porosity and permeability of TM are two important parameters that affect eye pressure distribution.
Keywords: Generalised porous medium model, Eye modelling, Aqueous humor flow, Intraocular pressure (IOP), Patient oriented, Heat transfer
College: College of Engineering