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A generalised porous medium approach to study thermo-fluid dynamics in human eyes

Alessandro Mauro, Nicola Massarotti, Mohamed Salahudeen, Mario R. Romano, Vito Romano, Perumal Nithiarasu Orcid Logo

Medical & Biological Engineering & Computing

Swansea University Author: Perumal Nithiarasu Orcid Logo

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DOI (Published version): 10.1007/s11517-018-1813-4

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The present work describes the application of the generalised porous medium model to study heat and fluid flow in healthy and glaucomatous eyes of different subject specimens, considering the presence of ocular cavities and porous tissues. The 2D computational model, implemented into the open-source...

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Published in: Medical & Biological Engineering & Computing
ISSN: 0140-0118 1741-0444
Published: 2018
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URI: https://cronfa.swan.ac.uk/Record/cronfa38914
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first_indexed 2018-03-02T14:27:54Z
last_indexed 2018-05-01T19:37:23Z
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spelling 2018-05-01T16:34:59.0417078 v2 38914 2018-03-02 A generalised porous medium approach to study thermo-fluid dynamics in human eyes 3b28bf59358fc2b9bd9a46897dbfc92d 0000-0002-4901-2980 Perumal Nithiarasu Perumal Nithiarasu true false 2018-03-02 CIVL The present work describes the application of the generalised porous medium model to study heat and fluid flow in healthy and glaucomatous eyes of different subject specimens, considering the presence of ocular cavities and porous tissues. The 2D computational model, implemented into the open-source software OpenFOAM, has been verified against benchmark data for mixed convection in domains partially filled with a porous medium. The verified model has been employed to simulate the thermo-fluid dynamic phenomena occurring in the anterior section of four patient-specific human eyes, considering the presence of anterior chamber (AC), trabecular meshwork (TM), Schlemm’s canal (SC), and collector channels (CC). The computational domains of the eye are extracted from tomographic images. The dependence of TM porosity and permeability on intraocular pressure (IOP) has been analysed in detail, and the differences between healthy and glaucomatous eye conditions have been highlighted, proving that the different physiological conditions of patients have a significant influence on the thermo-fluid dynamic phenomena. The influence of different eye positions (supine and standing) on thermo-fluid dynamic variables has been also investigated: results are presented in terms of velocity, pressure, temperature, friction coefficient and local Nusselt number. The results clearly indicate that porosity and permeability of TM are two important parameters that affect eye pressure distribution. Journal Article Medical & Biological Engineering & Computing 0140-0118 1741-0444 Generalised porous medium model, Eye modelling, Aqueous humor flow, Intraocular pressure (IOP), Patient oriented, Heat transfer 31 12 2018 2018-12-31 10.1007/s11517-018-1813-4 COLLEGE NANME Civil Engineering COLLEGE CODE CIVL Swansea University 2018-05-01T16:34:59.0417078 2018-03-02T08:44:55.8014175 Faculty of Science and Engineering School of Aerospace, Civil, Electrical, General and Mechanical Engineering - Civil Engineering Alessandro Mauro 1 Nicola Massarotti 2 Mohamed Salahudeen 3 Mario R. Romano 4 Vito Romano 5 Perumal Nithiarasu 0000-0002-4901-2980 6 0038914-18042018091759.pdf mauro2018.pdf 2018-04-18T09:17:59.7570000 Output 2573005 application/pdf Accepted Manuscript true 2019-03-22T00:00:00.0000000 true eng
title A generalised porous medium approach to study thermo-fluid dynamics in human eyes
spellingShingle A generalised porous medium approach to study thermo-fluid dynamics in human eyes
Perumal Nithiarasu
title_short A generalised porous medium approach to study thermo-fluid dynamics in human eyes
title_full A generalised porous medium approach to study thermo-fluid dynamics in human eyes
title_fullStr A generalised porous medium approach to study thermo-fluid dynamics in human eyes
title_full_unstemmed A generalised porous medium approach to study thermo-fluid dynamics in human eyes
title_sort A generalised porous medium approach to study thermo-fluid dynamics in human eyes
author_id_str_mv 3b28bf59358fc2b9bd9a46897dbfc92d
author_id_fullname_str_mv 3b28bf59358fc2b9bd9a46897dbfc92d_***_Perumal Nithiarasu
author Perumal Nithiarasu
author2 Alessandro Mauro
Nicola Massarotti
Mohamed Salahudeen
Mario R. Romano
Vito Romano
Perumal Nithiarasu
format Journal article
container_title Medical & Biological Engineering & Computing
publishDate 2018
institution Swansea University
issn 0140-0118
1741-0444
doi_str_mv 10.1007/s11517-018-1813-4
college_str Faculty of Science and Engineering
hierarchytype
hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Aerospace, Civil, Electrical, General and Mechanical Engineering - Civil Engineering{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Aerospace, Civil, Electrical, General and Mechanical Engineering - Civil Engineering
document_store_str 1
active_str 0
description The present work describes the application of the generalised porous medium model to study heat and fluid flow in healthy and glaucomatous eyes of different subject specimens, considering the presence of ocular cavities and porous tissues. The 2D computational model, implemented into the open-source software OpenFOAM, has been verified against benchmark data for mixed convection in domains partially filled with a porous medium. The verified model has been employed to simulate the thermo-fluid dynamic phenomena occurring in the anterior section of four patient-specific human eyes, considering the presence of anterior chamber (AC), trabecular meshwork (TM), Schlemm’s canal (SC), and collector channels (CC). The computational domains of the eye are extracted from tomographic images. The dependence of TM porosity and permeability on intraocular pressure (IOP) has been analysed in detail, and the differences between healthy and glaucomatous eye conditions have been highlighted, proving that the different physiological conditions of patients have a significant influence on the thermo-fluid dynamic phenomena. The influence of different eye positions (supine and standing) on thermo-fluid dynamic variables has been also investigated: results are presented in terms of velocity, pressure, temperature, friction coefficient and local Nusselt number. The results clearly indicate that porosity and permeability of TM are two important parameters that affect eye pressure distribution.
published_date 2018-12-31T03:49:43Z
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score 10.937357

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