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Sodium Tertiary Pentoxide: A Mild and Efficient Base to Make C-C Bond between Acetylenes and Aldehydes (or) Ketones Producing Propargyl Alcohols
Sebastian Antony Savarimuthu,
Hajeeth Thankappan,
Selvaraj Augustine Thomas,
Devarajan Gnanaprakasi Leo Prakash,
Leo Prakash 
ChemistrySelect, Volume: 3, Issue: 29, Pages: 8479 - 8482
Swansea University Author:
Leo Prakash
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DOI (Published version): 10.1002/slct.201801640
Abstract
This report confirms that sodium tertiary‐pentoxide is a very effective base for the nucleophilic addition of acetylenes to aldehydes and ketones in 1,4‐dioxane at room temperature. These mild and operationally simple procedures have been working well with a variety of aromatic and heteroaromatic al...
| Published in: | ChemistrySelect |
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| ISSN: | 2365-6549 |
| Published: |
2018
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| Online Access: |
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| URI: | https://cronfa.swan.ac.uk/Record/cronfa43524 |
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| Abstract: |
This report confirms that sodium tertiary‐pentoxide is a very effective base for the nucleophilic addition of acetylenes to aldehydes and ketones in 1,4‐dioxane at room temperature. These mild and operationally simple procedures have been working well with a variety of aromatic and heteroaromatic aldehydes and also equally working well with aliphatic, aromatic and heteroaromatic ketones. A very clean product of secondary and tertiary propargylic alcohols were obtained from 70–94% yield. This process has been explored in bulk scale synthesis on selected molecules and also adapted the column free purification for most of the substrates. |
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| Keywords: |
Aldehydes, Alkynes, C–C bond formation Ketones, Propargyl alcohols |
| College: |
Faculty of Science and Engineering |
| Issue: |
29 |
| Start Page: |
8479 |
| End Page: |
8482 |